Grace Young
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View article: Patient‐reported outcome measures in prostate research: a scoping review
Patient‐reported outcome measures in prostate research: a scoping review Open
Objectives To summarise how patient‐reported outcome measures (PROMs) are used in prostate research, specifically in the 10 years after the 2010 CONsolidated Standards Of Reporting Trials (CONSORT) guidelines were introduced. Methods The s…
View article: The Use of COMLEX-USA Performance When Considering DO Applicants to General Surgery Residency Programs
The Use of COMLEX-USA Performance When Considering DO Applicants to General Surgery Residency Programs Open
The results from this investigation indicate that COMLEX performance is predictive of ABS in-training and board certification performance. If program directors continue to use licensing examination performance as part of holistic review of…
View article: Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT
Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT Open
Background Lower urinary tract symptoms are common in older men and can be bothersome, leading to treatment. The UPSTREAM randomised controlled trial (Phase I) investigated whether assessment of these symptoms with invasive urodynamic test…
View article: PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: Implications for the interplay between human DNA damage tolerance pathways
PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: Implications for the interplay between human DNA damage tolerance pathways Open
The DNA genome is constantly exposed to agents, such as ultraviolet radiation (UVR), that can alter or eliminate its coding properties through covalent modifications of the template bases. Many of these damaging modifications (i.e., lesion…
View article: Five-year Follow-up of the Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment Methods—A Noninferiority Randomised Controlled Trial of Urodynamics
Five-year Follow-up of the Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment Methods—A Noninferiority Randomised Controlled Trial of Urodynamics Open
Five-year follow-up does not support the routine use of invasive urodynamics in reducing LUTS or rates of prostate surgery. Urodynamics should be used selectively in the evaluation of uncomplicated LUTS.
View article: O01 Rapid respiratory microbiological POCTs and antibiotic use in primary care: the RAPID-TEST RCT
O01 Rapid respiratory microbiological POCTs and antibiotic use in primary care: the RAPID-TEST RCT Open
Background Antibiotics are prescribed for over 50% of RTIs in primary care, despite good evidence most patients do not benefit. Rapid multiplex microbiological point-of-care-tests (POCTRM) determine the presence/ absence of respiratory pat…
View article: Rapid respiratory microbiological point-of-care-testing and antibiotic prescribing in primary care: Protocol for the RAPID-TEST randomised controlled trial
Rapid respiratory microbiological point-of-care-testing and antibiotic prescribing in primary care: Protocol for the RAPID-TEST randomised controlled trial Open
Background Antibiotics are prescribed for over 50% of respiratory tract infections in primary care, despite good evidence of there being no benefit to the patient, and evidence of over prescribing driving microbial resistance. The high tre…
View article: Structure of the human CTF18–RFC clamp loader bound to PCNA
Structure of the human CTF18–RFC clamp loader bound to PCNA Open
Sliding clamps like PCNA are crucial processivity factors for replicative polymerases, requiring specific clamp loaders for loading onto DNA. The human alternative clamp loader CTF18-RFC interacts with the leading strand polymerase Pol ε a…
View article: Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality
Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality Open
Importance The Cluster Randomized Trial of PSA Testing for Prostate Cancer (CAP) reported no effect of prostate-specific antigen (PSA) screening on prostate cancer mortality at a median 10-year follow-up (primary outcome), but the long-ter…
View article: 1877 Recruitment to a phase 3, RCT in Parkinson’s: strategies and association between participant characteristics and PI specialty
1877 Recruitment to a phase 3, RCT in Parkinson’s: strategies and association between participant characteristics and PI specialty Open
Introduction Falls are a common complication of Parkinson’s disease, driven in part by an underlying cholinergic deficit that contributes to gait and cognitive impairment. Phase 2 studies have established that amelioration of this deficit …
View article: A multifaceted intervention to reduce antibiotic prescribing among CHIldren with acute COugh and respiratory tract infection: the CHICO cluster RCT
A multifaceted intervention to reduce antibiotic prescribing among CHIldren with acute COugh and respiratory tract infection: the CHICO cluster RCT Open
Background Clinical uncertainty in primary care regarding the prognosis of children with respiratory tract infections contributes to the unnecessary use of antibiotics. Improved identification of children at low risk of future hospitalisat…
View article: An assessment of surgery core rotation quality at osteopathic medical schools
An assessment of surgery core rotation quality at osteopathic medical schools Open
Context Osteopathic medical schools have traditionally placed a heavy emphasis on the field of primary care. While graduating osteopathic students continue to pursue family medicine, internal medicine, and pediatrics at higher rates than t…
View article: Multi-faceted intervention to improve management of antibiotics for children presenting to primary care with acute cough and respiratory tract infection (CHICO): efficient cluster randomised controlled trial
Multi-faceted intervention to improve management of antibiotics for children presenting to primary care with acute cough and respiratory tract infection (CHICO): efficient cluster randomised controlled trial Open
Objective To assess whether an easy-to-use multifaceted intervention for children presenting to primary care with respiratory tract infections would reduce antibiotic dispensing, without increasing hospital admissions for respiratory tract…
View article: Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer
Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer Open
After 15 years of follow-up, prostate cancer-specific mortality was low regardless of the treatment assigned. Thus, the choice of therapy involves weighing trade-offs between benefits and harms associated with treatments for localized pros…
View article: Sources of online information utilized by caregivers of pediatric patients with atopic dermatitis
Sources of online information utilized by caregivers of pediatric patients with atopic dermatitis Open
There is limited information on the use of websites and social media platforms among dermatology patients. This survey study of 210 children with atopic dermatitis and their caretakers who attended dermatology clinic from 6/1/2020 through …
View article: Can primary care research be conducted more efficiently using routinely reported practice-level data: a cluster randomised controlled trial conducted in England?
Can primary care research be conducted more efficiently using routinely reported practice-level data: a cluster randomised controlled trial conducted in England? Open
Objectives Conducting randomised controlled trials (RCTs) in primary care is challenging; recruiting patients during time-limited or remote consultations can increase selection bias and physical access to patients’ notes is costly and time…
View article: Vision function in children 10 years after grade 3 or 4 intraventricular haemorrhage with ventricular dilation: A masked prospective study
Vision function in children 10 years after grade 3 or 4 intraventricular haemorrhage with ventricular dilation: A masked prospective study Open
Aim We examined children 10 to 11 years after grade 3 or 4 intraventricular haemorrhage and ventricular dilation (IVHVD) and investigated whether the grade of IVHVD affected their visual outcome. We explored associations between visual out…
View article: Functional and quality of life outcomes of localised prostate cancer treatments (Prostate Testing for Cancer and Treatment <scp>[ProtecT]</scp> study)
Functional and quality of life outcomes of localised prostate cancer treatments (Prostate Testing for Cancer and Treatment <span>[ProtecT]</span> study) Open
Objective To investigate the functional and quality of life (QoL) outcomes of treatments for localised prostate cancer and inform treatment decision‐making. Patients and Methods Men aged 50–69 years diagnosed with localised prostate cancer…
View article: A Quantum Polynomial-Time Solution to The Dihedral Hidden Subgroup Problem
A Quantum Polynomial-Time Solution to The Dihedral Hidden Subgroup Problem Open
We present a polynomial-time quantum algorithm for the Hidden Subgroup Problem over $\mathbb{D}_{2^n}$. The usual approach to the Hidden Subgroup Problem relies on harmonic analysis in the domain of the problem, and the best known algorith…
View article: Understanding the Taboo of Incest in the American South Through Analysis of Southern Gothic Literature
Understanding the Taboo of Incest in the American South Through Analysis of Southern Gothic Literature Open
In this paper, I am exploring the topic of incest through the lens of the Southern Gothic literature genre. I am interested in why the American South has the stereotype of having more prevalence of individuals who engage in incest in mount…
View article: Protocol for an ‘efficient design’ cluster randomised controlled trial to evaluate a complex intervention to improve antibiotic prescribing for CHIldren presenting to primary care with acute COugh and respiratory tract infection: the CHICO study
Protocol for an ‘efficient design’ cluster randomised controlled trial to evaluate a complex intervention to improve antibiotic prescribing for CHIldren presenting to primary care with acute COugh and respiratory tract infection: the CHICO study Open
Introduction Respiratory tract infections (RTIs) in children are common and present major resource implications for primary care. Unnecessary use of antibiotics is associated with the development and proliferation of antimicrobial resistan…
View article: Oral prednisolone for acute lower respiratory tract infection in clinically unrecognised asthma: an exploratory analysis of the Oral Steroids for Acute Cough (OSAC) randomised controlled trial
Oral prednisolone for acute lower respiratory tract infection in clinically unrecognised asthma: an exploratory analysis of the Oral Steroids for Acute Cough (OSAC) randomised controlled trial Open
Background Acute lower respiratory tract infection (ALRTI) is often treated in primary care with antibiotics. The recent Oral Steroids for Acute Cough (OSAC) randomised controlled trial (RCT) showed corticosteroids were not an effective al…
View article: Urodynamics tests for the diagnosis and management of bladder outlet obstruction in men: the UPSTREAM non-inferiority RCT
Urodynamics tests for the diagnosis and management of bladder outlet obstruction in men: the UPSTREAM non-inferiority RCT Open
Background Lower urinary tract symptoms (LUTS) in men may indicate bladder outlet obstruction (BOO) or weakness, known as detrusor underactivity (DU). Severe bothersome LUTS are a common indication for surgery. The diagnostic tests may inc…
View article: Thulium laser transurethral vaporesection versus transurethral resection of the prostate for benign prostatic obstruction: the UNBLOCS RCT
Thulium laser transurethral vaporesection versus transurethral resection of the prostate for benign prostatic obstruction: the UNBLOCS RCT Open
Background Transurethral resection of the prostate (TURP) is the standard operation for benign prostatic obstruction (BPO). Thulium laser transurethral vaporesection of the prostate (ThuVARP) vaporises and resects the prostate using a tech…
View article: Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer: the ProtecT three-arm RCT
Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer: the ProtecT three-arm RCT Open
Background Prostate cancer is the most common cancer among men in the UK. Prostate-specific antigen testing followed by biopsy leads to overdetection, overtreatment as well as undertreatment of the disease. Evidence of treatment effectiven…