Gregor Ebert
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View article: A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis Open
View article: Prediction of COVID-19 disease progression by multiparametric analysis of circulating extracellular vesicles with flow cytometry
Prediction of COVID-19 disease progression by multiparametric analysis of circulating extracellular vesicles with flow cytometry Open
Extracellular vesicles (EVs) are released from all cells of the body. They are considered to mirror the state of the cells from which they are released and circulate in the blood, suggesting a possible use of EV analysis for diagnostic pur…
View article: HERV-K10 as a mediator of immune modulation in hepatitis infections
HERV-K10 as a mediator of immune modulation in hepatitis infections Open
The human genome contains ~8% of endogenous retroviruses (HERVs), whose reactivation has been implicated in diseases such as cancer and autoimmune disorders. Among these, HERV-K10 has attracted attention for its potential role in immune mo…
View article: A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID
A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID Open
View article: SARS‐CoV‐2 Productively Infects Human Hepatocytes and Induces Cell Death
SARS‐CoV‐2 Productively Infects Human Hepatocytes and Induces Cell Death Open
SARS‐CoV‐2 infection is accompanied by elevated liver enzymes, and patients with pre‐existing liver conditions experience more severe disease. While it was known that SARS‐CoV‐2 infects human hepatocytes, our study determines the mechanism…
View article: Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19 Open
View article: A novel PLpro inhibitor scaffold that protects mice from Long-COVID
A novel PLpro inhibitor scaffold that protects mice from Long-COVID Open
The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has highlighted the vulnerability of a globally connected population to zoonotic viruses. The only FDA-approved coronavirus antiviral, Paxlovid, targets the essential SARS-CoV-2 ma…
View article: Creating bottom-up RNA transfer vehicles from synthetic protein assemblies
Creating bottom-up RNA transfer vehicles from synthetic protein assemblies Open
Evolution guides biological systems to populate ecological niches, with viruses being one of the most successful examples of that principle. Viruses evolved over billions of years for the efficient transfer of nucleic acids. Although highl…
View article: Multi-omics characterization of the monkeypox virus infection
Multi-omics characterization of the monkeypox virus infection Open
Multiple omics analyzes of Vaccinia virus (VACV) infection have defined molecular characteristics of poxvirus biology. However, little is known about the monkeypox (mpox) virus (MPXV) in humans, which has a different disease manifestation …
View article: Light-Induced Transformation of Virus-Like Particles on TiO<sub>2</sub>
Light-Induced Transformation of Virus-Like Particles on TiO<sub>2</sub> Open
Titanium dioxide (TiO2) shows significant potential as a self-cleaning material to inactivate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and prevent virus transmission. This study provides insights into the imp…
View article: Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors
Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors Open
Emerging RNA viruses, including SARS-CoV-2, continue to be a major threat. Cell entry of SARS-CoV-2 particles via the endosomal pathway involves cysteine cathepsins. Due to ubiquitous expression, cathepsin L (CatL) is considered a promisin…
View article: Major open questions in the hepatitis B and D field – Proceedings of the inaugural International emerging hepatitis B and hepatitis D researchers workshop
Major open questions in the hepatitis B and D field – Proceedings of the inaugural International emerging hepatitis B and hepatitis D researchers workshop Open
View article: Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting
Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting Open
View article: Murine norovirus infection of macrophages induces intrinsic apoptosis as the major form of programmed cell death
Murine norovirus infection of macrophages induces intrinsic apoptosis as the major form of programmed cell death Open
Human norovirus is the leading cause of acute gastroenteritis worldwide, however despite the significance of this pathogen, we have a limited understanding of how noroviruses cause disease, and modulate the innate immune response. Programm…
View article: Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections Open
Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (M pro ), its moderate activity in M pro inhibition assays hints at a second target. Indeed,…
View article: A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation Open
Across the globe, 2-3% of humans carry the p.Ser132Pro single nucleotide polymorphism in MLKL , the terminal effector protein of the inflammatory form of programmed cell death, necroptosis. Here we show that this substitution confers a gai…
View article: Structural elucidation and antiviral activity of cathepsin L inhibitors with carbonyl and epoxide warheads
Structural elucidation and antiviral activity of cathepsin L inhibitors with carbonyl and epoxide warheads Open
Emerging RNA viruses including SARS-CoV-2 continue to be a major threat around the globe. The cell entry of SARS-CoV-2 particles via the endosomal pathway involves the cysteine protease cathepsin L (CatL) among other proteases. CatL is ren…
View article: Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections Open
Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro inhibition assays hints at a second target. Indeed, we…
View article: SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19
SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 Open
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been associated mainly with a range of neurological symptoms, including brain fog and brain tissue loss, raising conc…
View article: Adsorption and Inactivation of SARS-CoV-2 on the Surface of Anatase TiO<sub>2</sub>(101)
Adsorption and Inactivation of SARS-CoV-2 on the Surface of Anatase TiO<sub>2</sub>(101) Open
We investigated the adsorption of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), the virus responsible for the current pandemic, on the surface of the model catalyst TiO2(101) using atomic force microscopy, trans…
View article: A common human<i>MLKL</i>polymorphism confers resistance to negative regulation by phosphorylation
A common human<i>MLKL</i>polymorphism confers resistance to negative regulation by phosphorylation Open
Across the globe, 2-3% of humans carry the p.Ser132Pro single nucleotide polymorphism in MLKL , the terminal effector protein of the inflammatory form of programmed cell death, necroptosis. We show that this substitution confers a gain in …
View article: Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death
Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death Open
View article: Targeted protein degradation at the host–pathogen interface
Targeted protein degradation at the host–pathogen interface Open
Infectious diseases remain a major burden to global health. Despite the implementation of successful vaccination campaigns and efficient drugs, the increasing emergence of pathogenic vaccine or treatment resistance demands novel therapeuti…
View article: Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models
Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models Open
View article: The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation Open
View article: The inflammasome-activated cytokine IL-1β is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential
The inflammasome-activated cytokine IL-1β is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential Open
Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in wide-spread diseases. Therefore, IL-1β activity must be fine-tuned to enable antimicrobial responses whilst limiting collat…
View article: Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors
Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors Open
Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limitations of many standard-of-care chemotherapies: undesirable drug toxicity, side-effects, resistance and high c…
View article: Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models
Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models Open
The specific targeting of inhibitor of apoptosis (IAP) proteins by Smac-mimetic (SM) drugs, such as birinapant, has been tested in clinical trials of acute myeloid leukemia (AML) and certain solid cancers. Despite their promising safety pr…
View article: Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2 Open
View article: Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo
Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo Open
Chronic hepatitis B virus (HBV) infection remains a global health threat and affects hundreds of millions worldwide. Small molecule compounds that mimic natural antagonists of inhibitor of apoptosis (IAP) proteins, known as Smac-mimetics (…