Gregor Eichele
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View article: Regulation of hedonic feeding rhythms by circadian clocks in leptin-receptive neurons
Regulation of hedonic feeding rhythms by circadian clocks in leptin-receptive neurons Open
Our data describe a local clock-controlled central leptin gating mechanism that modulates hedonic food intake rhythms and impacts metabolic homeostasis.
View article: Preface: Special Issue on Probing the Open Ocean With the Research Sailing Yacht <i>Eugen Seibold</i> for Climate Geochemistry
Preface: Special Issue on Probing the Open Ocean With the Research Sailing Yacht <i>Eugen Seibold</i> for Climate Geochemistry Open
The 72‐foot sailing yacht Eugen Seibold is a new research platform for contamination‐free sampling of the water column and atmosphere for biological, chemical, and physical properties, and the exchange processes between the two realms. Ult…
View article: RNA sequencing indicates widespread conservation of circadian clocks in marine zooplankton
RNA sequencing indicates widespread conservation of circadian clocks in marine zooplankton Open
Zooplankton are important eukaryotic constituents of marine ecosystems characterized by limited motility in the water. These metazoans predominantly occupy intermediate trophic levels and energetically link primary producers to higher trop…
View article: Extracellular vesicles derived from the choroid plexus trigger the differentiation of neural stem cells
Extracellular vesicles derived from the choroid plexus trigger the differentiation of neural stem cells Open
The choroid plexus secrets cerebrospinal fluid (CSF) composed of electrolytes, cytokines, growth factors, metabolites and extracellular vesicles (EVs) that flow through the interconnected brain ventricles. On their course, CSF components c…
View article: Postnatal expression of the lysine methyltransferase SETD1B is essential for learning and the regulation of neuron‐enriched genes
Postnatal expression of the lysine methyltransferase SETD1B is essential for learning and the regulation of neuron‐enriched genes Open
In mammals, histone 3 lysine 4 methylation (H3K4me) is mediated by six different lysine methyltransferases. Among these enzymes, SETD1B (SET domain containing 1b) has been linked to syndromic intellectual disability in human subjects, but …
View article: Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes
Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes Open
Histone 3 lysine 4 methylation (H3K4me) is mediated by six different lysine methyltransferases. Amongst these enzymes SET domain containing 1b (SETD1B) has been linked to syndromic intellectual disability but its role in the postnatal brai…
View article: Dissecting and modeling photic and melanopsin effects to predict sleep disturbances induced by irregular light exposure in mice
Dissecting and modeling photic and melanopsin effects to predict sleep disturbances induced by irregular light exposure in mice Open
Significance Light pervasively affects physiology and behavior, especially the sleep–wake cycle (SWc), which is generated by clock signaling in the suprachiasmatic nuclei (SCN). Light synchronizes this clock and additionally exerts direct …
View article: Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein
Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein Open
α-synuclein (αSyn) is the main protein component of Lewy bodies, intracellular inclusions found in the brain of Parkinson’s disease (PD) patients. Neurotoxic αSyn species are broadly modified post-translationally and, in patients with gene…
View article: Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex
Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex Open
Intermediate progenitor cells (IPCs) are neocortical neuronal precursors. Although IPCs play crucial roles in corticogenesis, their molecular features remain largely unknown. In this study, we aimed to characterize the molecular profile of…
View article: Transcriptome Response and Spatial Pattern of Gene Expression in the Primate Subventricular Zone Neurogenic Niche After Cerebral Ischemia
Transcriptome Response and Spatial Pattern of Gene Expression in the Primate Subventricular Zone Neurogenic Niche After Cerebral Ischemia Open
The main stem cell niche for neurogenesis in the adult mammalian brain is the subventricular zone (SVZ) that extends along the cerebral lateral ventricles. We aimed at characterizing the initial molecular responses of the macaque monkey SV…
View article: Alternative catalytic residues in the active site of Esco acetyltransferases
Alternative catalytic residues in the active site of Esco acetyltransferases Open
Cohesin is a protein complex whose core subunits, Smc1, Smc3, Scc1, and SA1/SA2 form a ring-like structure encircling the DNA. Cohesins play a key role in the expression, repair, and segregation of eukaryotic genomes. Following a catalytic…
View article: Melanopsin-dependent direct photic effects are equal to clock-driven effects in shaping the nychthemeral sleep-wake cycle
Melanopsin-dependent direct photic effects are equal to clock-driven effects in shaping the nychthemeral sleep-wake cycle Open
Nychthemeral sleep-wake cycles (SWc) are known to be generated by the circadian clock in suprachiasmatic nuclei (SCN), entrained to the light-dark cycle. Light also exerts direct acute effects on sleep and waking. However, under longer pho…
View article: Meiotic sex chromosome cohesion and autosomal synapsis are supported by<i>Esco2</i>
Meiotic sex chromosome cohesion and autosomal synapsis are supported by<i>Esco2</i> Open
In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but poorly understood roles in the formation of chromosome axial…
View article: Cilia-driven flows in the brain third ventricle
Cilia-driven flows in the brain third ventricle Open
The brain ventricles are interconnected, elaborate cavities that traverse the brain. They are filled with cerebrospinal fluid (CSF) that is, to a large part, produced by the choroid plexus, a secretory epithelium that reaches into the vent…
View article: Alternative catalytic residues in the active site of Esco acetyltransferases
Alternative catalytic residues in the active site of Esco acetyltransferases Open
Cohesin is a protein complex encircles the DNA and regulates the separation of sister chromatids during cell division. Following a catalytic mechanism that is insufficiently understood, Esco1 and Esco2 acetyltransferases acetylate Smc3 sub…
View article: Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters
Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters Open
Many physiological processes exhibit circadian rhythms driven by cellular clocks composed of interlinked activating and repressing elements. To investigate temporal regulation in this molecular oscillator, we combined mouse genetic approac…
View article: Author response: Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters
Author response: Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Many physiological processes exhibit circa…
View article: Automated image processing of fluorescent images: the end to manual counting?
Automated image processing of fluorescent images: the end to manual counting? Open
High-throughput experiments are characterized by the generation of large amounts of imaging data in short time which requires fast, automated and reliable methods for processing and analysis. Most of the gold standard methods for quantita…
View article: Genetic background-dependent effects of murine micro RNAs on circadian clock function
Genetic background-dependent effects of murine micro RNAs on circadian clock function Open
MicroRNAs (miRs) are important regulators of a wide range of biological processes. Antagomir studies suggest an implication of miR-132 in the functionality of the mammalian circadian clock. miR-212 and miR-132 are tandemly processed from t…
View article: Synchronization of the mammalian circadian timing system: Light can control peripheral clocks independently of the SCN clock
Synchronization of the mammalian circadian timing system: Light can control peripheral clocks independently of the SCN clock Open
A vast network of cellular circadian clocks regulates 24‐hour rhythms of behavior and physiology in mammals. Complex environments are characterized by multiple, and often conflicting time signals demanding flexible mechanisms of adaptation…