Gregor Mönke
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View article: Circadian clock activity in human umbilical vein endothelial cells of preterm and term neonates
Circadian clock activity in human umbilical vein endothelial cells of preterm and term neonates Open
Background During mammalian gestation, fetal circadian rhythms are thought to be mainly controlled by maternal signals. In humans, the initiation and activity of central and peripheral circadian clocks is largely unknown. This study aimed …
View article: Systems Neuroscience Computing in Python (SyNCoPy): a python package for large-scale analysis of electrophysiological data
Systems Neuroscience Computing in Python (SyNCoPy): a python package for large-scale analysis of electrophysiological data Open
We introduce an open-source Python package for the analysis of large-scale electrophysiological data, named SyNCoPy, which stands for Systems Neuroscience Computing in Python. The package includes signal processing analyses across time (e.…
View article: Spectral estimation at the edge
Spectral estimation at the edge Open
Cognitive functions depend on neuronal communication, which is subserved by the synchronization of neuronal rhythms. Rhythms are characterized by their frequency, power and phase. If the phase of a rhythm just preceding an input is predict…
View article: Nonreciprocal synchronization in embryonic oscillator ensembles
Nonreciprocal synchronization in embryonic oscillator ensembles Open
Synchronization of coupled oscillators is a universal phenomenon encountered across different scales and contexts, e.g., chemical wave patterns, superconductors, and the unison applause we witness in concert halls. The existence of common …
View article: Mitoclone2: an R package for elucidating clonal structure in single-cell RNA-sequencing data using mitochondrial variants
Mitoclone2: an R package for elucidating clonal structure in single-cell RNA-sequencing data using mitochondrial variants Open
Clonal cell population dynamics play a critical role in both disease and development. Due to high mitochondrial mutation rates under both healthy and diseased conditions, mitochondrial genomic variability is a particularly useful resource …
View article: Systems Neuroscience Computing in Python (SyNCoPy): A Python Package for Large-scale Analysis of Electrophysiological Data
Systems Neuroscience Computing in Python (SyNCoPy): A Python Package for Large-scale Analysis of Electrophysiological Data Open
We introduce an open-source Python package for the analysis of large-scale electrophysiological data called SyNCoPy, for Systems Neuroscience Computing in Python. The package includes signal processing analyses across time (e.g. time-lock …
View article: Nonreciprocal synchronization in embryonic oscillator ensembles
Nonreciprocal synchronization in embryonic oscillator ensembles Open
Synchronization of coupled oscillators is a universal phenomenon encountered across different scales and contexts e.g., chemical wave patterns, superconductors and the unison applause we witness in concert halls. The existence of common un…
View article: Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock
Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock Open
Living systems exhibit an unmatched complexity, due to countless, entangled interactions across scales. Here, we aim to understand a complex system, that is, segmentation timing in mouse embryos, without a reference to these detailed inter…
View article: Author response: Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock
Author response: Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Living syst…
View article: Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation
Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation Open
A fundamental requirement for embryonic development is the coordination of signaling activities in space and time. A notable example in vertebrate embryos is found during somitogenesis, where gene expression oscillations linked to the segm…
View article: Analysis of Complex Circadian Time Series Data Using Wavelets
Analysis of Complex Circadian Time Series Data Using Wavelets Open
Experiments that compare rhythmic properties across different genetic alterations and entrainment conditions underlie some of the most important breakthroughs in circadian biology. A robust estimation of the rhythmic properties of the circ…
View article: Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock
Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock Open
Living systems exhibit an unmatched complexity, due to countless, entangled interactions across scales. Here we aim to understand a complex system, i.e. segmentation timing in mouse embryos, without a reference to these detailed interactio…
View article: Ethology of morphogenesis reveals the design principles of cnidarian size and shape development
Ethology of morphogenesis reveals the design principles of cnidarian size and shape development Open
Summary During development, organisms interact with their natural habitats while undergoing morphological changes, yet it remains unclear whether the interplay between developing systems and their environments impacts animal morphogenesis.…
View article: Mechanical competition alters the cellular interpretation of an endogenous genetic program
Mechanical competition alters the cellular interpretation of an endogenous genetic program Open
The intrinsic genetic program of a cell is not sufficient to explain all of the cell’s activities. External mechanical stimuli are increasingly recognized as determinants of cell behavior. In the epithelial folding event that constitutes t…
View article: Analysis of complex circadian time series data using wavelets
Analysis of complex circadian time series data using wavelets Open
Experiments that compare rhythmic properties across different genetic alterations and entrainment conditions underlie some of the most important breakthroughs in circadian biology. A robust estimation of the rhythmic properties of the circ…
View article: Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma
Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma Open
The migrational propensity of neuroblastoma is affected by cell identity, but the mechanisms behind the divergence remain unknown. Using RNAi and time-lapse imaging, we show that ADRN-type NB cells exhibit RAC1- and kalirin-dependent nucle…
View article: Mechanical competition alters the cellular interpretation of an endogenous genetic programme
Mechanical competition alters the cellular interpretation of an endogenous genetic programme Open
The intrinsic genetic programme of a cell is not sufficient to explain all of the cell’s activities. External mechanical stimuli are increasingly recognized as determinants of cell behaviour. In the epithelial folding event that constitute…
View article: Optimal time frequency analysis for biological data - pyBOAT
Optimal time frequency analysis for biological data - pyBOAT Open
Methods for the quantification of rhythmic biological signals have been essential for the discovery of function and design of biological oscillators. Advances in live measurements have allowed recordings of unprecedented resolution reveali…
View article: Optimal time frequency analysis for biological data - pyBOAT
Optimal time frequency analysis for biological data - pyBOAT Open
Methods for the quantification of rhythmic biological signals have been essential for the discovery of function and design of biological oscillators. Advances in live measurements have allowed recordings of unprecedented resolution reveali…
View article: Hydraulic control of embryo size, tissue shape and cell fate
Hydraulic control of embryo size, tissue shape and cell fate Open
Size control is fundamental in tissue development and homeostasis 1,2 . While the role of cell proliferation in this process has been widely studied 3 , the mechanisms of organ size control and how it impacts cell fates remain elusive. Her…