Gregor Tegl
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View article: Ligand‐Directed Chemistry on Glycoside Hydrolases – A Proof of Concept Study
Ligand‐Directed Chemistry on Glycoside Hydrolases – A Proof of Concept Study Open
Selective covalent labelling of enzymes using small molecule probes has advanced the scopes of protein profiling. The covalent bond formation to a specific target is the key step of activity‐based protein profiling (ABPP), a method which h…
View article: A Synthetic Gene Library Yields a Previously Unknown Glycoside Phosphorylase That Degrades and Assembles Poly-β-1,3-GlcNAc, Completing the Suite of β-Linked GlcNAc Polysaccharides
A Synthetic Gene Library Yields a Previously Unknown Glycoside Phosphorylase That Degrades and Assembles Poly-β-1,3-GlcNAc, Completing the Suite of β-Linked GlcNAc Polysaccharides Open
The considerable utility of glycoside phosphorylases (GPs) has led to substantial efforts over the past two decades to expand the breadth of known GP activities. Driven largely by the increase of available genomic DNA sequence data, the ga…
N-Glycan Degradation Pathways in Gut- and Soil-Dwelling Actinobacteria Share Common Core Genes Open
N-Glycosylation is a fundamental protein modification found in both eukaryotes and archaea. Despite lacking N-glycans, many commensal and pathogenic bacteria have developed mechanisms to degrade these isoforms for a variety of functions, i…
Glycosyltransferase Co‐Immobilization for Natural Product Glycosylation: Cascade Biosynthesis of the <i>C</i>‐Glucoside Nothofagin with Efficient Reuse of Enzymes Open
Sugar nucleotide‐dependent (Leloir) glycosyltransferases are synthetically important for oligosaccharides and small molecule glycosides. Their practical use involves one‐pot cascade reactions to regenerate the sugar nucleotide substrate. G…
Corrigendum: Facile Formation of β‐thioGlcNAc Linkages to Thiol‐Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase Open
In the Acknowledgement of this Communication a project number needs to be added. The last sentence should read: “We acknowledge financial support … as well as a Schroedinger fellowship to G.T. from the Austrian Science Fund (FWF, Schroedin…
View article: 2-<i>O</i>-Benzyloxycarbonyl protected glycosyl donors: a revival of carbonate-mediated anchimeric assistance for diastereoselective glycosylation
2-<i>O</i>-Benzyloxycarbonyl protected glycosyl donors: a revival of carbonate-mediated anchimeric assistance for diastereoselective glycosylation Open
Benzyloxycarbonyl can be used as participating group for the diastereoselective glycosylation of base-labile products and the synthesis of glycosyl esters.
Facile Formation of β‐thioGlcNAc Linkages to Thiol‐Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase Open
Thioglycosides are hydrolase‐resistant mimics of O‐linked glycosides that can serve as valuable probes for studying the role of glycosides in biological processes. The development of an efficient, enzyme‐mediated synthesis of thioglycoside…
Facile Formation of β‐thioGlcNAc Linkages to Thiol‐Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase Open
Thioglycosides are hydrolase‐resistant mimics of O‐linked glycosides that can serve as valuable probes for studying the role of glycosides in biological processes. The development of an efficient, enzyme‐mediated synthesis of thioglycoside…
The chemo enzymatic functionalization of chitosan zeolite particles provides antioxidant and antimicrobial properties Open
Silicate‐based microporous materials like zeolites are nano enabled particles and used for various applications including pharmaceutical formulations. This study reports on the chemo‐enzymatic functionalization of chitosan‐zeolite particle…
Enzymatic Systems for Cellulose Acetate Degradation Open
Cellulose acetate (CA)-based materials, like cigarette filters, contribute to landscape pollution challenging municipal authorities and manufacturers. This study investigates the potential of enzymes to degrade CA and to be potentially inc…
Commercial cellulases from <i>Trichoderma longibrachiatum</i> enable a large-scale production of chito-oligosaccharides Open
Chito-oligosaccharides (COSs) are a substance class of high interest due to various beneficial bioactive properties. However, detailed mechanistic and application-related investigations are limited due to the poor availability of COSs with…