Gregor Wenzel
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View article: Changes in Functional Connectivity Relate to Modulation of Cognitive Control by Subthalamic Stimulation
Changes in Functional Connectivity Relate to Modulation of Cognitive Control by Subthalamic Stimulation Open
Subthalamic (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) patients not only improves kinematic parameters of movement but also modulates cognitive control in the motor and non‐motor domain, especially in situations of high…
View article: <scp>StimFit—</scp>A Data‐Driven Algorithm for Automated Deep Brain Stimulation Programming
<span>StimFit—</span>A Data‐Driven Algorithm for Automated Deep Brain Stimulation Programming Open
Background Finding the optimal deep brain stimulation (DBS) parameters from a multitude of possible combinations by trial and error is time consuming and requires highly trained medical personnel. Objective We developed an automated algori…
View article: Linking Profiles of Pathway Activation with Clinical Motor Improvements – a Retrospective Computational Study
Linking Profiles of Pathway Activation with Clinical Motor Improvements – a Retrospective Computational Study Open
Deep brain stimulation (DBS) is an established therapy for patients with Parkinson’s disease. In silico computer models for DBS allow to pre-select a set of potentially optimal stimulation parameters. If efficacious, they could further car…
View article: CLOVER-DBS: Algorithm-Guided Deep Brain Stimulation-Programming Based on External Sensor Feedback Evaluated in a Prospective, Randomized, Crossover, Double-Blind, Two-Center Study
CLOVER-DBS: Algorithm-Guided Deep Brain Stimulation-Programming Based on External Sensor Feedback Evaluated in a Prospective, Randomized, Crossover, Double-Blind, Two-Center Study Open
Background: Recent technological advances in deep brain stimulation (DBS) (e.g., directional leads, multiple independent current sources) lead to increasing DBS-optimization burden. Techniques to streamline and facilitate programming could…
View article: Left Prefrontal Connectivity Links Subthalamic Stimulation with Depressive Symptoms
Left Prefrontal Connectivity Links Subthalamic Stimulation with Depressive Symptoms Open
Objective Subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson's disease (PD) not only stimulates focal target structures but also affects distributed brain networks. The impact this network modulation has on non‐motor DBS eff…
View article: Deep brain stimulation induced normalization of the human functional connectome in Parkinson’s disease
Deep brain stimulation induced normalization of the human functional connectome in Parkinson’s disease Open
Deep brain stimulation has local effects on the target structure, but also global effects via distributed brain networks. Horn et al. show that modulating the activity of the subthalamic nucleus in patients with Parkinson’s disease normali…
View article: Modulating the human functional connectome using deep brain stimulation
Modulating the human functional connectome using deep brain stimulation Open
Neuroimaging has seen a paradigm shift from a formal description of local activity patterns toward studying distributed brain networks. The recently defined framework of the ‘human connectome’ allows to globally analyse parts of the brain …
View article: Connectivity Predicts deep brain stimulation outcome in <scp>P</scp>arkinson disease
Connectivity Predicts deep brain stimulation outcome in <span>P</span>arkinson disease Open
Objective The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may depend on connectivity between the stimulation site and other brain regions, but which regions and whether connectivity can predict outcome in patients re…