Gregor Zaun
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View article: Protocol for the establishment of murine orthotopic lung tumors and the assessment of contralateral pulmonal metastasis by flow cytometry
Protocol for the establishment of murine orthotopic lung tumors and the assessment of contralateral pulmonal metastasis by flow cytometry Open
View article: <scp>ABO</scp>‐Blood Group Associates With Survival Outcomes in Patients With Metastatic Non‐Small Cell Lung Cancer Treated With Pembrolizumab Monotherapy
<span>ABO</span>‐Blood Group Associates With Survival Outcomes in Patients With Metastatic Non‐Small Cell Lung Cancer Treated With Pembrolizumab Monotherapy Open
Purpose In patients with metastatic non‐small cell lung cancer (NSCLC) with high programmed death‐ligand 1 (PD‐L1) expression, there is still a lack of biomarkers to identify patients with maximum benefit from first‐line treatment with che…
View article: BCL-B Promotes Lung Cancer Invasiveness by Direct Inhibition of BOK
BCL-B Promotes Lung Cancer Invasiveness by Direct Inhibition of BOK Open
Expression of BCL-B, an anti-apoptotic BCL-2 family member, is correlated with worse survival in lung adenocarcinomas. Here, we show that BCL-B can mitigate cell death initiation through interaction with the effector protein BOK. We found …
View article: Minimally invasive determination of pancreatic ductal adenocarcinoma ( <scp>PDAC</scp> ) subtype by means of circulating cell‐free <scp>RNA</scp>
Minimally invasive determination of pancreatic ductal adenocarcinoma ( <span>PDAC</span> ) subtype by means of circulating cell‐free <span>RNA</span> Open
Pancreatic ductal adenocarcinoma (PDAC) comprises two clinically relevant molecular subtypes that are currently determined using tissue biopsies, which are spatially biased and highly invasive. We used whole transcriptome sequencing of 10 …
View article: PD-L1 expression associates with favorable survival of patients with cancer of unknown primary (CUP) not treated with checkpoint inhibitors
PD-L1 expression associates with favorable survival of patients with cancer of unknown primary (CUP) not treated with checkpoint inhibitors Open
Cancer of unknown primary (CUP) is a heterogeneous entity with limited overall survival (OS) in most patients. Prognostic biomarkers are needed, particularly for treatment stratification. We investigated the impact of programmed death-liga…
View article: Investigation of screening questions to identify insomnia in cancer patients
Investigation of screening questions to identify insomnia in cancer patients Open
View article: Early Metabolic Response by PET Predicts Sensitivity to Next-Line Targeted Therapy in<i>EGFR</i>-Mutated Lung Cancer with Unknown Mechanism of Acquired Resistance
Early Metabolic Response by PET Predicts Sensitivity to Next-Line Targeted Therapy in<i>EGFR</i>-Mutated Lung Cancer with Unknown Mechanism of Acquired Resistance Open
Targeted therapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has established the precision oncology paradigm in lung cancer. Most patients with EGFR-mutated lung cancer respond but eventually acqui…
View article: Identification of Key Genes Associated with Tumor Microenvironment Infiltration and Survival in Gastric Adenocarcinoma via Bioinformatics Analysis
Identification of Key Genes Associated with Tumor Microenvironment Infiltration and Survival in Gastric Adenocarcinoma via Bioinformatics Analysis Open
Objective: Gastric carcinoma (GC) is the fifth most commonly diagnosed cancer and the third leading cause of cancer-related deaths globally. The tumor microenvironment plays a significant role in the pathogenesis, prognosis, and response t…
View article: Comprehensive biomarker diagnostics of unfavorable cancer of unknown primary to identify patients eligible for precision medical therapies
Comprehensive biomarker diagnostics of unfavorable cancer of unknown primary to identify patients eligible for precision medical therapies Open
In a real-world setting precision medicine for patients with CUP is severely restricted by tissue availability, and a limited spectrum of actionable alterations. Progress for patients may require emphasizing the need for sufficient biopsie…
View article: Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers
Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers Open
DNA methylation is an extensively studied, stable, and fundamental epigenetic alteration in most cancer types 1 . Single-base-pair resolution analyses of DNA methylation is currently feasible 2 . Analysis of DNA methylation, in liquid biop…
View article: Impact of encorafenib on survival of patients with BRAFV600E-mutant metastatic colorectal cancer in a real-world setting
Impact of encorafenib on survival of patients with BRAFV600E-mutant metastatic colorectal cancer in a real-world setting Open
View article: Impact of encorafenib on survival of patients with BRAF V600E -mutant metastatic colorectal cancer in a real-world setting
Impact of encorafenib on survival of patients with BRAF V600E -mutant metastatic colorectal cancer in a real-world setting Open
Purpose: Patients with BRAF V600E mutant metastatic colorectal cancer (mCRC) have a dismal prognosis. The best strategies in these patients remain elusive. Against this background, we report the clinical course of patients with BRAF V600E …
View article: SUV<sub>max</sub>Above 20 in<sup>18</sup>F-FDG PET/CT at Initial Diagnostic Workup Associates with Favorable Survival in Patients with Cancer of Unknown Primary
SUV<sub>max</sub>Above 20 in<sup>18</sup>F-FDG PET/CT at Initial Diagnostic Workup Associates with Favorable Survival in Patients with Cancer of Unknown Primary Open
Cancer of unknown primary (CUP) is a heterogeneous entity with a limited prognosis. Novel prognostic markers are needed for patient stratification in prospective clinical trials exploring innovative therapies. Methods: In CUP patien…
View article: Favorable survival outcomes in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer sequentially treated with a tyrosine kinase inhibitor and osimertinib in a real-world setting
Favorable survival outcomes in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer sequentially treated with a tyrosine kinase inhibitor and osimertinib in a real-world setting Open
View article: Supplementary Material for: Clinical outcome and treatment sequences of patients with advanced pancreatic cancer treated with contemporary chemotherapy protocols
Supplementary Material for: Clinical outcome and treatment sequences of patients with advanced pancreatic cancer treated with contemporary chemotherapy protocols Open
Introduction Systemic therapy is firmly established in patients with advanced or metastatic pancreatic ductal adenocarcinoma (PDAC). Clinical efficacy is still modest and options are limited. Combination therapy protocols such as FOLFIRINO…
View article: A prognostic systemic inflammation score (SIS) in patients with advanced intrahepatic cholangiocarcinoma
A prognostic systemic inflammation score (SIS) in patients with advanced intrahepatic cholangiocarcinoma Open
View article: Prognostic factors in nonsmall cell lung cancer: insights from the German CRISP registry
Prognostic factors in nonsmall cell lung cancer: insights from the German CRISP registry Open
Introduction Understanding prognosis, especially long-term outcome, in advanced nonsmall cell lung cancer (NSCLC) is crucial to inform patients, guide treatment and plan supportive and palliative care. Methods Prognostic factors influencin…
View article: Arenavirus Induced CCL5 Expression Causes NK Cell-Mediated Melanoma Regression
Arenavirus Induced CCL5 Expression Causes NK Cell-Mediated Melanoma Regression Open
Immune activation within the tumor microenvironment is one promising approach to induce tumor regression. Certain viruses including oncolytic viruses such as the herpes simplex virus (HSV) and non-oncolytic viruses such as the lymphocytic …
View article: In Reply
In Reply Open
Computed tomography of the upper abdomen after the intravenous administration of contrast mediumThere is a subcapsular splenic hematoma (star) with active bleeding (arrow), as well as hematoperitoneum with perihepatic free fluid (triangle)…
View article: CUP Syndrome
CUP Syndrome Open
A combination of conventional and innovative diagnostic methods enables the provision of highly refined therapeutic strategies to patients with CUP who are undergoing treatment in interdisciplinary cancer centers.