Gregorio Iraola
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View article: A Latin American perspective on microbiome research
A Latin American perspective on microbiome research Open
The human gut microbiome plays a crucial role in human health, adapting and responding to changes in diet, environment, and lifestyle. However, current microbiome research is heavily biased toward high-income countries, leaving regions suc…
View article: Draft genome sequence of <i>Catenibacterium mistuoki</i> isolated from the fecal sample of a melanoma patient with complete response to immunotherapy
Draft genome sequence of <i>Catenibacterium mistuoki</i> isolated from the fecal sample of a melanoma patient with complete response to immunotherapy Open
A strain of Catenibacterium spp. was isolated from a fecal sample of a patient diagnosed with stage IV melanoma in December 2008. The patient began treatment with the immune checkpoint inhibitor pembrolizumab in May 2016 and has since exhi…
View article: An antibiotic produced by Pseudomonas fluorescens CFBP2392 with antifungal activity against Rhizoctonia solani
An antibiotic produced by Pseudomonas fluorescens CFBP2392 with antifungal activity against Rhizoctonia solani Open
Pseudomonas fluorescens CFBP2392 has been recognized as a potential biocontrol agent due to its ability to suppress damping-off and root rot disease. This isolate has antibacterial activity in vitro as many other strains from the Pseudomon…
View article: What have we learned from a case of convalescent plasma treatment in a two-time kidney transplant recipient COVID-19 patient? A case report from the perspective of viral load evolution and immune response
What have we learned from a case of convalescent plasma treatment in a two-time kidney transplant recipient COVID-19 patient? A case report from the perspective of viral load evolution and immune response Open
Coronavirus disease 2019 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, can have a wide range of clinical manifestations, ranging from asymptomatic disease to potentially…
View article: Fast and cost-effective SARS-CoV-2 variant detection using Oxford Nanopore full-length spike gene sequencing
Fast and cost-effective SARS-CoV-2 variant detection using Oxford Nanopore full-length spike gene sequencing Open
Most biologically relevant and diagnostic mutations in the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genome have been identified in the S gene through global genomic surveillance efforts. However, large-scale whole-genom…
View article: One-year monitoring SARS-CoV-2 RNA surface contamination in hospitals reveals no correlation with organic material and negative pressure as a limiting factor for contamination
One-year monitoring SARS-CoV-2 RNA surface contamination in hospitals reveals no correlation with organic material and negative pressure as a limiting factor for contamination Open
Understanding transmission routes of SARS-CoV-2 is crucial to establish effective interventions in healthcare institutions. Although the role of surface contamination in SARS-CoV-2 transmission has been controversial, fomites have been pro…
View article: Human microbiota drives hospital-associated antimicrobial resistance dissemination in the urban environment and mirrors patient case rates
Human microbiota drives hospital-associated antimicrobial resistance dissemination in the urban environment and mirrors patient case rates Open
Background The microbial community composition of urban environments is primarily determined by human activity. The use of metagenomics to explore how microbial communities are shaped in a city provides a novel input that can improve decis…
View article: Comprehensive Phenotyping in Inflammatory Bowel Disease: Search for Biomarker Algorithms in the Transkingdom Interactions Context
Comprehensive Phenotyping in Inflammatory Bowel Disease: Search for Biomarker Algorithms in the Transkingdom Interactions Context Open
Inflammatory bowel disease (IBD) is the most common form of intestinal inflammation associated with a dysregulated immune system response to the commensal microbiota in a genetically susceptible host. IBD includes ulcerative colitis (UC) a…
View article: A history of the MetaSUB consortium: Tracking urban microbes around the globe
A history of the MetaSUB consortium: Tracking urban microbes around the globe Open
The MetaSUB Consortium, founded in 2015, is a global consortium with an interdisciplinary team of clinicians, scientists, bioinformaticians, engineers, and designers, with members from more than 100 countries across the globe. This network…
View article: ¿What did we learn from Convalescent plasma treatment in a COVID-19 patient two-time kidney transplanted? A case report from the viral and immune response evolution perspective
¿What did we learn from Convalescent plasma treatment in a COVID-19 patient two-time kidney transplanted? A case report from the viral and immune response evolution perspective Open
Background: COVID-19, an infectious disease caused by SARS-CoV-2 virus, can provoke a vast range of clinical manifestations, ranging from asymptomatic to potentially life-threatening complications. At the beginning, convalescent plasma the…
View article: First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America
First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America Open
The asymptomatic carriage of this strain in the urinary tract warns of difficulties for detection and reporting of emerging carbapenem-resistant clones in new geographic areas where these are not endemic.
View article: Improved detection and classification of plasmids from circularized and fragmented assemblies
Improved detection and classification of plasmids from circularized and fragmented assemblies Open
Plasmids are mobile genetic elements important for bacterial adaptation. The study of plasmids from sequencing data is challenging because short reads produce fragmented assemblies, requiring of subsequent discrimination between chromosome…
View article: Human microbiota drives hospital-associated antimicrobial resistance dissemination in the urban environment and mirrors patient case rates
Human microbiota drives hospital-associated antimicrobial resistance dissemination in the urban environment and mirrors patient case rates Open
Background: The microbial community composition of urban environments is primarily determined by human activity. The use of metagenomics to explore how microbial communities are shaped in a city provides a novel input that can improve deci…
View article: A Two-Time Point Analysis of Gut Microbiota in the General Population of Buenos Aires and Its Variation Due to Preventive and Compulsory Social Isolation During the COVID-19 Pandemic
A Two-Time Point Analysis of Gut Microbiota in the General Population of Buenos Aires and Its Variation Due to Preventive and Compulsory Social Isolation During the COVID-19 Pandemic Open
The COVID-19 pandemic poses a great challenge to global public health. The extraordinary daily use of household disinfectants and cleaning products, social distancing and the loss of everyday situations that allow contact between individua…
View article: montevideo_sewage_AMR
montevideo_sewage_AMR Open
Scripts and datasest to reproduce paper figures and analyses.
View article: Spirochaetes_flagellum
Spirochaetes_flagellum Open
Files necessary to reproduce analyses of flagellar gene searches in Spirochaetes genomes.
View article: montevideo_sewage_AMR
montevideo_sewage_AMR Open
Scripts and datasest to reproduce paper figures and analyses.
View article: Real-Time Genomic Surveillance for SARS-CoV-2 Variants of Concern, Uruguay
Real-Time Genomic Surveillance for SARS-CoV-2 Variants of Concern, Uruguay Open
We developed a genomic surveillance program for real-time monitoring of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in Uruguay. We report on a PCR method for SARS-CoV-2 VOCs, the surveillance wor…
View article: Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay
Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay Open
Uruguay controlled the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein, we analyzed the country-wide genetic…
View article: Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H Spike mutations in Uruguay
Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H Spike mutations in Uruguay Open
Uruguay was able to control the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein we analyzed the country-wide…
View article: Case Report: Early Transcontinental Import of SARS-CoV-2 Variant of Concern 202012/01 (B.1.1.7) From Europe to Uruguay
Case Report: Early Transcontinental Import of SARS-CoV-2 Variant of Concern 202012/01 (B.1.1.7) From Europe to Uruguay Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant B.1.1.7 causes a more transmissible and apparently more severe disease. We report its early introduction from Europe to South America from a traveler who arrived in Urugu…