Gregory A. Ballash
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View article: Escherichia coli causing urinary tract infections in dogs and humans differ in population structure and pathogenic potential: a comparative genomic analysis
Escherichia coli causing urinary tract infections in dogs and humans differ in population structure and pathogenic potential: a comparative genomic analysis Open
Objective To identify host-specific pathogenesis and intraspecies transmission potential of spatiotemporally related Escherichia coli causing human and canine urinary tract infections (UTIs). Methods We collected 103 unique E coli isolates…
View article: Survey study based on the assessment and management of pain in cats by veterinary professionals after elective sterilization procedures
Survey study based on the assessment and management of pain in cats by veterinary professionals after elective sterilization procedures Open
Objectives Effective pain management is essential for feline patients, particularly those undergoing elective procedures such as ovariohysterectomy (OVH) and orchiectomy. Despite the availability of objective validated pain scales and mult…
View article: Pet treats, Salmonella, and antimicrobial resistance; a One Health problem
Pet treats, Salmonella, and antimicrobial resistance; a One Health problem Open
Zoonotic pathogens, including Salmonella and antimicrobial resistant bacteria, may contaminate the food or treats consumed by our pets. These may directly impact the health of the pets or may be transferred to humans who are in close conta…
View article: The impact of zinc supplementation on carbapenem MICs among bacteria expressing IMP metallo-beta-lactamase
The impact of zinc supplementation on carbapenem MICs among bacteria expressing IMP metallo-beta-lactamase Open
Antibiotic-resistant infections cause an estimated 2.8 million illnesses and 35,900 deaths annually in the USA. Carbapenems are a class of antibiotics that are generally reserved to treat life-threatening invasive infections including seps…
View article: The impact of zinc supplementation on carbapenem MICs among bacteria expressing IMP metallo-beta-lactamase
The impact of zinc supplementation on carbapenem MICs among bacteria expressing IMP metallo-beta-lactamase Open
2. Abstract Antibiotic-resistant infections cause an estimated 2.8 million illnesses and 35,900 deaths annually in the US. Carbapenems are a class of antibiotics that are generally reserved to treat life-threatening invasive infections inc…
View article: The impact of zinc supplementation on carbapenem MICs among bacteria expressing IMP metallo-beta-lactamase
The impact of zinc supplementation on carbapenem MICs among bacteria expressing IMP metallo-beta-lactamase Open
2. Abstract Antibiotic-resistant infections cause an estimated 2.8 million illnesses and 35,900 deaths annually in the US. Carbapenems are a class of antibiotics that are generally reserved to treat life-threatening invasive infections inc…
View article: Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections
Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections Open
View article: The impact of taxonomic family and supplemental zinc on minimum inhibitory concentration against carbapenem antibiotics among bacteria expressing IMP metallo-beta-lactamase
The impact of taxonomic family and supplemental zinc on minimum inhibitory concentration against carbapenem antibiotics among bacteria expressing IMP metallo-beta-lactamase Open
2. Abstract Antibiotic-resistant infections cause an estimated 2.8 million illnesses and 35,900 deaths annually in the US. Carbapenems are a class of antibiotics that are generally reserved to treat life-threatening invasive infections inc…
View article: Murine Ribonuclease 6 Limits Bacterial Dissemination During Experimental Urinary Tract Infection
Murine Ribonuclease 6 Limits Bacterial Dissemination During Experimental Urinary Tract Infection Open
Introduction: The Ribonuclease (RNase) A superfamily encodes cationic antimicrobial proteins with potent microbicidal activity toward uropathogenic bacteria. Ribonuclease 6 (RNase6) is an evolutionarily conserved, leukocyte-derived antimic…
View article: A complex cyclical One Health pathway drives the emergence and dissemination of antimicrobial resistance
A complex cyclical One Health pathway drives the emergence and dissemination of antimicrobial resistance Open
Since their commercialization, scientists have known that antimicrobial use kills or inhibits susceptible bacteria while allowing resistant bacteria to survive and expand. Today there is widespread antimicrobial resistance (AMR), even to a…
View article: The One Health dissemination of antimicrobial resistance occurs in both natural and clinical environments
The One Health dissemination of antimicrobial resistance occurs in both natural and clinical environments Open
Once considered to be a simple cause-and-effect relationship with localized impact, the concept of how antimicrobial use drives antimicrobial resistance is now recognized as a complex, transdisciplinary problem on a global scale. While the…
View article: Previous Antibiotic Exposure Reshapes the Population Structure of Infecting Uropathogenic Escherichia coli Strains by Selecting for Antibiotic Resistance over Urovirulence
Previous Antibiotic Exposure Reshapes the Population Structure of Infecting Uropathogenic Escherichia coli Strains by Selecting for Antibiotic Resistance over Urovirulence Open
Urinary tract infections (UTIs) are one of the most common infections of dogs and humans. While antibiotic therapy is the standard of care for UTIs and other infections, antibiotic exposure may influence the pathogenic profile of subsequen…
View article: Antimicrobial-Resistant <i>Enterobacterales</i> Recovered from the Environment of Two Zoological Institutions Include Enterobacter cloacae Complex ST171 Producing KPC-4 Carbapenemase
Antimicrobial-Resistant <i>Enterobacterales</i> Recovered from the Environment of Two Zoological Institutions Include Enterobacter cloacae Complex ST171 Producing KPC-4 Carbapenemase Open
Environmental surfaces can be a source of antimicrobial-resistant (AMR) bacteria that pose a risk to human and animal health. Zoological institutions are unique environments where exotic animals, staff, and visitors intermingle and antimic…
View article: Human Ribonuclease 6 Has a Protective Role during Experimental Urinary Tract Infection
Human Ribonuclease 6 Has a Protective Role during Experimental Urinary Tract Infection Open
Mounting evidence suggests that antimicrobial peptides and proteins (AMPs) belonging to the RNase A superfamily have a critical role in defending the bladder and kidney from bacterial infection. RNase 6 has been identified as a potent, leu…
View article: Supplementary Material for: Human Ribonuclease 6 has a Protective Role During Experimental Urinary Tract Infection
Supplementary Material for: Human Ribonuclease 6 has a Protective Role During Experimental Urinary Tract Infection Open
Mounting evidence suggests that antimicrobial peptides and proteins (AMPs) belonging to the RNase A superfamily have a critical role in defending the bladder and kidney from bacterial infection. RNase 6 has been identified as a potent, leu…
View article: Fish as sentinels of antimicrobial resistant bacteria, epidemic carbapenemase genes, and antibiotics in surface water
Fish as sentinels of antimicrobial resistant bacteria, epidemic carbapenemase genes, and antibiotics in surface water Open
Surface waters, especially those receiving wastewater flows, can disseminate antimicrobial resistant bacteria (ARB), antimicrobial resistance genes (ARG), and antibiotics. In the Scioto River of central Ohio, United States, we evaluated fi…
View article: Pathogenomics and clinical recurrence influence biofilm capacity of Escherichia coli isolated from canine urinary tract infections
Pathogenomics and clinical recurrence influence biofilm capacity of Escherichia coli isolated from canine urinary tract infections Open
Biofilm formation enhances bacteria’s ability to colonize unique niches while protecting themselves from environmental stressors. Escherichia coli that colonize the urinary tract can protect themselves from the harsh bladder environment by…
View article: Colonization of White-Tailed Deer (Odocoileus virginianus) from Urban and Suburban Environments with Cephalosporinase- and Carbapenemase-Producing Enterobacterales
Colonization of White-Tailed Deer (Odocoileus virginianus) from Urban and Suburban Environments with Cephalosporinase- and Carbapenemase-Producing Enterobacterales Open
The role of wildlife in the spread of antimicrobial resistance is not fully characterized. Some wildlife, including white-tailed deer (WTD), can thrive in suburban and urban environments.
View article: Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care
Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care Open
View article: Additional file 9 of Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care
Additional file 9 of Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care Open
Additional file 9. Differentially abundant microbes by health status in 25 birds with matched healthy / enteritis samples. Based on an ANCOM, Clostridia were significantly increased in relative abundance in lorikeets with enteritis as comp…
View article: Additional file 5 of Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care
Additional file 5 of Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care Open
Additional file 5. CZA Microbial community composition by sex, species, and age.
View article: Additional file 8 of Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care
Additional file 8 of Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care Open
Additional file 8. Differentially abundant microbes by health status. Based on an ANCOM, Clostridia were significantly increased in relative abundance in lorikeets with enteritis as compared to healthy lorikeets. This analysis included 157…
View article: Additional file 10 of Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care
Additional file 10 of Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care Open
Additional file 10. Denver Zoo (DZ) Lorikeet Demographics. The p-value for sex were based on a χ2 test. A Kruskal-Wallis test was used to calculate the p-value for age. The Freeman-Halton extension of the Fisher’s Exact test was used to ca…
View article: Autologous platelet-rich plasma effects on Staphylococcus aureus–induced chondrocyte death in an in vitro bovine septic arthritis model
Autologous platelet-rich plasma effects on Staphylococcus aureus–induced chondrocyte death in an in vitro bovine septic arthritis model Open
OBJECTIVE To investigate the chondroprotective effects of autologous platelet-rich plasma (PRP), ampicillin-sulbactam (AmpS), or PRP combined with AmpS (PRP+AmpS) in an in vitro chondrocyte explant model of bovine Staphylococcus aureus –in…
View article: Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care
Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care Open
Background Enteritis is a common cause of morbidity and mortality in lorikeets that can be challenging to diagnose and treat. In this study, we examine gut microbiota in two lorikeet flocks with enteritis (Columbus Zoo and Aquarium – CZA; …
View article: Temporal Trends in Antimicrobial Resistance of Fecal Escherichia coli from Deer
Temporal Trends in Antimicrobial Resistance of Fecal Escherichia coli from Deer Open
View article: Antimicrobial resistant bacteria recovered from retail ground meat products in the US include a Raoultella ornithinolytica co-harboring blaKPC-2 and blaNDM-5
Antimicrobial resistant bacteria recovered from retail ground meat products in the US include a Raoultella ornithinolytica co-harboring blaKPC-2 and blaNDM-5 Open
View article: Alterations in gut microbiota linked to provenance, sex, and chronic wasting disease in white-tailed deer (Odocoileus virginianus)
Alterations in gut microbiota linked to provenance, sex, and chronic wasting disease in white-tailed deer (Odocoileus virginianus) Open
View article: Alterations in gut microbiota linked to provenance, sex, and chronic wasting disease in white-tailed deer (<i>Odocoileus virginianus</i>)
Alterations in gut microbiota linked to provenance, sex, and chronic wasting disease in white-tailed deer (<i>Odocoileus virginianus</i>) Open
Chronic wasting disease (CWD) is a fatal, contagious, neurodegenerative prion disease affecting both free-ranging and captive cervid species. CWD is spread via direct or indirect contact or oral ingestion of prions. In the gastrointestinal…
Carbapenemase-producing Enterobacteriaceae and Aeromonas spp. present in wastewater treatment plant effluent and nearby surface waters in the US Open