Gregory A. Davidson
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View article: Photo-activatable Ub-PCNA probes reveal new structural features of the <i>Saccharomyces cerevisiae</i> Polη/PCNA complex
Photo-activatable Ub-PCNA probes reveal new structural features of the <i>Saccharomyces cerevisiae</i> Polη/PCNA complex Open
The Y-family DNA polymerase η (Polη) is critical for the synthesis past damaged DNA nucleotides in yeast through translesion DNA synthesis (TLS). TLS is initiated by monoubiquitination of proliferating cell nuclear antigen (PCNA) and the s…
View article: Chemical methods for protein site-specific ubiquitination
Chemical methods for protein site-specific ubiquitination Open
Chemical methods for protein site-specific ubiquitination are important for the understanding of Ub signaling.
View article: Activity-based ubiquitin-protein probes reveal target protein specificity of deubiquitinating enzymes
Activity-based ubiquitin-protein probes reveal target protein specificity of deubiquitinating enzymes Open
Activity-based Ub-PCNA probes identify deubiquitinating enzymes (DUBs) specific for PCNA and demonstrate site-specific deubiquitination by DUBs.
View article: Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis
Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis Open
Platelets play an essential role in hemostasis and wound healing by facilitating thrombus formation at sites of injury. Platelets also mediate inflammation and contain several pro-inflammatory molecules including cytokines and chemokines t…