Gregory B. Waypa
YOU?
Author Swipe
View article: Mitochondria regulate proliferation in adult cardiac myocytes
Mitochondria regulate proliferation in adult cardiac myocytes Open
Newborn mammalian cardiomyocytes quickly transition from a fetal to an adult phenotype that utilizes mitochondrial oxidative phosphorylation but loses mitotic capacity. We tested whether forced reversal of adult cardiomyocytes back to a fe…
View article: Role of Hypoxia-Inducible Factors in Regulating Right Ventricular Function and Remodeling during Chronic Hypoxia–induced Pulmonary Hypertension
Role of Hypoxia-Inducible Factors in Regulating Right Ventricular Function and Remodeling during Chronic Hypoxia–induced Pulmonary Hypertension Open
Pulmonary hypertension (PH) and right ventricular (RV) hypertrophy frequently develop in patients with hypoxic lung disease. Chronic alveolar hypoxia (CH) promotes sustained pulmonary vasoconstriction and pulmonary artery (PA) remodeling b…
View article: Roles of HIF1 and HIF2 in pulmonary hypertension: it all depends on the context
Roles of HIF1 and HIF2 in pulmonary hypertension: it all depends on the context Open
HIF1 and HIF2 can play complementary, opposing or unrelated roles in mediating the response to low oxygen levels in different cell types. This study shows HIF2 plays a dominant role in mediating the development of PH in response to envi…
View article: JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension
JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension Open
The hypoxic response is a stress response triggered by low oxygen tension. Hypoxia-inducible factors (HIFs) play a prominent role in the pathobiology of hypoxia-associated conditions, including pulmonary hypertension (PH) and polycythemia.…
View article: Aberrant cGMP signaling persists during recovery in mice with oxygen-induced pulmonary hypertension
Aberrant cGMP signaling persists during recovery in mice with oxygen-induced pulmonary hypertension Open
Bronchopulmonary dysplasia (BPD), a common complication of preterm birth, is associated with pulmonary hypertension (PH) in 25% of infants with moderate to severe BPD. Neonatal mice exposed to hyperoxia for 14d develop lung disease similar…
View article: Redox signaling during hypoxia in mammalian cells
Redox signaling during hypoxia in mammalian cells Open
Hypoxia triggers a wide range of protective responses in mammalian cells, which are mediated through transcriptional and post-translational mechanisms. Redox signaling in cells by reactive oxygen species (ROS) such as hydrogen peroxide (H<…
View article: MP PLOS One manuscript data.pdf
MP PLOS One manuscript data.pdf Open
Data for a manuscript entitled "Aberrant cGMP Signaling Persists During Recovery in Mice with Oxygen-InducedPulmonary Hypertension".
View article: O 2 sensing, mitochondria and ROS signaling: The fog is lifting
O 2 sensing, mitochondria and ROS signaling: The fog is lifting Open