Gregory Constantine
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View article: Multi-trait Analysis of GWAS Expands Eosinophilic Esophagitis Genetic Susceptibility and Polygenic Risk Scores
Multi-trait Analysis of GWAS Expands Eosinophilic Esophagitis Genetic Susceptibility and Polygenic Risk Scores Open
Atopic diseases, including eosinophilic esophagitis (EoE), are driven in part by genetic susceptibility. We performed a genome-wide association study (GWAS) of 1,757 EoE and 14,467 population controls, identifying 11 independent genetic ri…
View article: Multi-trait Analysis of GWAS Expands Eosinophilic Esophagitis Genetic Susceptibility and Polygenic Risk Scores
Multi-trait Analysis of GWAS Expands Eosinophilic Esophagitis Genetic Susceptibility and Polygenic Risk Scores Open
Atopic diseases, including eosinophilic esophagitis (EoE), are driven in part by genetic susceptibility. We performed a genome-wide association study (GWAS) of 1,757 EoE and 14,467 population controls, identifying 11 independent genetic ri…
View article: The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1
The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1 Open
Our findings indicate that APS-1, which is caused by AIRE deficiency, is characterized by excessive, multiorgan interferon-γ-mediated responses. JAK inhibition with ruxolitinib in five patients showed promising results. (Funded by the Nati…
View article: Overlap of eosinophilic esophagitis with inborn errors of immunity and immune dysregulation
Overlap of eosinophilic esophagitis with inborn errors of immunity and immune dysregulation Open
View article: Dupilumab Use in Patients with Hypereosinophilic Syndrome: A Multi-Center Case Series
Dupilumab Use in Patients with Hypereosinophilic Syndrome: A Multi-Center Case Series Open
View article: Evaluation of elevated serum tryptase among individuals with eosinophilic gastrointestinal disorders
Evaluation of elevated serum tryptase among individuals with eosinophilic gastrointestinal disorders Open
View article: Mepolizumab incompletely suppresses clinical flares in a pilot study of episodic angioedema with eosinophilia
Mepolizumab incompletely suppresses clinical flares in a pilot study of episodic angioedema with eosinophilia Open
View article: Implementation of a problem-based, gamified immunology curriculum increased engagement and comprehension in Allergy-Immunology fellows-in-training
Implementation of a problem-based, gamified immunology curriculum increased engagement and comprehension in Allergy-Immunology fellows-in-training Open
View article: Mepolizumab is ineffective for treatment of episodic angioedema with eosinophilia in a pilot study
Mepolizumab is ineffective for treatment of episodic angioedema with eosinophilia in a pilot study Open
View article: False-Negative Testing for FIP1L1::PDGFRA by Fluorescence in situ Hybridization Is a Frequent Cause of Diagnostic Delay
False-Negative Testing for FIP1L1::PDGFRA by Fluorescence in situ Hybridization Is a Frequent Cause of Diagnostic Delay Open
The imatinib-sensitive fusion gene FIP1L1::PDGFRA is the most frequent molecular abnormality identified in patients with eosinophilic myeloid neoplasms. Rapid recognition of this mutation is essential given the poor prognosis of PDGFRA-ass…
View article: Supplementary Material for: False-Negative Testing for <i>FIP1L1::</i><i>PDGFRA</i> by Fluorescence in situ Hybridization Is a Frequent Cause of Diagnostic Delay
Supplementary Material for: False-Negative Testing for <i>FIP1L1::</i><i>PDGFRA</i> by Fluorescence in situ Hybridization Is a Frequent Cause of Diagnostic Delay Open
The imatinib-sensitive fusion gene FIP1L1::PDGFRA is the most frequent molecular abnormality identified in patients with eosinophilic myeloid neoplasms. Rapid recognition of this mutation is essential given the poor prognosis of …
View article: Recent advances in understanding the role of eosinophils
Recent advances in understanding the role of eosinophils Open
Our understanding of eosinophil biology, development, and regulation has dramatically increased in the past decade, leading to new paradigms for the role of eosinophils in human health and disease and, perhaps more importantly, providing i…
View article: "Rank-based Models for Predicting Trauma-Related Organ Failure"
"Rank-based Models for Predicting Trauma-Related Organ Failure" Open
Gregory M Constantine1*, Marius G Buliga2, Rodica RA Constantine3, Yoram Vodovotz PhD4,5, Rami A Namas MD4,5 and Timothy R Billiar MD4,5 Author Affiliations 1Department of Mathematics and The McGowan Institute for Regenerative Medicine, Un…
View article: Remission of indolent systemic mastocytosis in the absence of targeted therapy
Remission of indolent systemic mastocytosis in the absence of targeted therapy Open
View article: Nodular regenerative hyperplasia in X-linked agammaglobulinemia: An underestimated and severe complication
Nodular regenerative hyperplasia in X-linked agammaglobulinemia: An underestimated and severe complication Open
View article: Regional cerebral cholinergic nerve terminal integrity and cardinal motor features in Parkinson’s disease
Regional cerebral cholinergic nerve terminal integrity and cardinal motor features in Parkinson’s disease Open
Clinical effects of anti-cholinergic drugs implicate cholinergic systems alterations in the pathophysiology of some cardinal motor impairments in Parkinson’s disease. The topography of affected cholinergic systems deficits and motor domain…
View article: Recent advances in understanding inherited deficiencies in immunity to infections
Recent advances in understanding inherited deficiencies in immunity to infections Open
The immune system is central to our interactions with the world in which we live and importantly dictates our response to potential allergens, toxins, and pathogens to which we are constantly exposed. Understanding the mechanisms that unde…
View article: Platelet-derived growth factor receptor-alpha-positive myeloid neoplasm presenting as eosinophilic gastrointestinal disease
Platelet-derived growth factor receptor-alpha-positive myeloid neoplasm presenting as eosinophilic gastrointestinal disease Open
View article: Ascorbic acid-induced oxalate nephropathy: a case report and discussion of pathologic mechanisms
Ascorbic acid-induced oxalate nephropathy: a case report and discussion of pathologic mechanisms Open
View article: Table of Contents
Table of Contents Open
View article: Combination Steroid and Test‐based Food Elimination for Eosinophilic Esophagitis
Combination Steroid and Test‐based Food Elimination for Eosinophilic Esophagitis Open
Objectives: Eosinophilic esophagitis (EoE) is a clinicopathologic disorder characterized by infiltration of eosinophils into the esophagus. Primary treatment approaches include topical corticosteroids and/or food elimination. The aim of th…
View article: Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients
Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients Open
Inflammation induced by traumatic brain injury (TBI) is complex, individual-specific, and associated with morbidity and mortality. We sought to develop dynamic, data-driven, predictive computational models of TBI-induced inflammation based…
View article: Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death
Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death Open
Inflammation induced by traumatic brain injury (TBI) is a complex mediator of morbidity and mortality. We have previously demonstrated the utility of both data-driven and mechanistic models in settings of traumatic injury. We hypothesized …
View article: Biomarkers Associated with Pressure Ulcer Formation in Traumatic Spinal Cord Individuals with Pneumonia
Biomarkers Associated with Pressure Ulcer Formation in Traumatic Spinal Cord Individuals with Pneumonia Open