Gregory Dutra
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View article: Media on‐demand: Continuous reconstitution of a chemically defined media directly from solids
Media on‐demand: Continuous reconstitution of a chemically defined media directly from solids Open
Chemically defined media are reconstituted batchwise and stored in hold tanks until use. To avoid large hold tanks and batchwise production of media, we developed continuous on‐demand reconstitutions directly from solids consisting of a ho…
View article: Continuous capture of recombinant antibodies by ZnCl<b><sub>2</sub></b> precipitation without polyethylene glycol
Continuous capture of recombinant antibodies by ZnCl<b><sub>2</sub></b> precipitation without polyethylene glycol Open
The capture of recombinant antibodies from cell culture broth is the first critical step of downstream processing. We were able to develop a precipitation‐based method for the capture and purification of monoclonal antibodies based on diva…
View article: Understanding the interaction between pDNA and different chromatographic supports
Understanding the interaction between pDNA and different chromatographic supports Open
Gene Therapy and DNA vaccines are recent therapies that take advantage of the potential of plasmid DNA as a therapeutic molecule for the treatment and cure of several diseases. In the last decade both techniques have received a great deal …