Gregory E. Holt
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View article: TILDA-X: Transcriptome-Informed Lung Cancer Disparities via Explainable AI
TILDA-X: Transcriptome-Informed Lung Cancer Disparities via Explainable AI Open
Background: Lung cancer is a leading cause of cancer-related mortality, with disparities in incidence and outcomes observed across different racial and sex groups. Identifying both patient-specific and cohort-specific disparity biomarkers …
View article: Metabolomics and Cytokine Signatures in COVID-19: Uncovering Immunometabolism in Pathogenesis
Metabolomics and Cytokine Signatures in COVID-19: Uncovering Immunometabolism in Pathogenesis Open
Background: This study aimed to analyze metabolic changes in blood samples from patients with confirmed COVID-19 to explore the correlation between metabolomics and cytokines in survivors and non-survivors of SARS-CoV-2 infection. Understa…
View article: Successful Treatment of Refractory Disseminated Coccidioidomycosis with Adjunctive Interferon-γ
Successful Treatment of Refractory Disseminated Coccidioidomycosis with Adjunctive Interferon-γ Open
Background Coccidioidomycosis (CM) is an infection caused by the Coccidioides ssp., which are endemic to the southwestern United States and Mexico. Most cases of CM are asymptomatic or cause mild respiratory illness, but 1% progress to ext…
View article: Investigating Metabolic Phenotypes for Sarcoidosis Diagnosis and Exploring Immunometabolic Profiles to Unravel Disease Mechanisms
Investigating Metabolic Phenotypes for Sarcoidosis Diagnosis and Exploring Immunometabolic Profiles to Unravel Disease Mechanisms Open
Background: Sarcoidosis is a granulomatous disease affecting multiple organ systems and poses a diagnostic challenge due to its diverse clinical manifestations and absence of specific diagnostic tests. Currently, blood biomarkers such as A…
View article: EP11.01-06 SPD-CD40L Prevents Tumor Growth via Recruitment of Immune Cells to the Tumor Microenvironment
EP11.01-06 SPD-CD40L Prevents Tumor Growth via Recruitment of Immune Cells to the Tumor Microenvironment Open
View article: Supplementary Figure 1 from Dendritic Cell–Activating Vaccine Adjuvants Differ in the Ability to Elicit Antitumor Immunity Due to an Adjuvant-Specific Induction of Immunosuppressive Cells
Supplementary Figure 1 from Dendritic Cell–Activating Vaccine Adjuvants Differ in the Ability to Elicit Antitumor Immunity Due to an Adjuvant-Specific Induction of Immunosuppressive Cells Open
PDF file, 86KB, The administration of anti-Gr-1 and anti-CD25 mAb can deplete MDSC and Treg cells respectively.
View article: Data from Dendritic Cell–Activating Vaccine Adjuvants Differ in the Ability to Elicit Antitumor Immunity Due to an Adjuvant-Specific Induction of Immunosuppressive Cells
Data from Dendritic Cell–Activating Vaccine Adjuvants Differ in the Ability to Elicit Antitumor Immunity Due to an Adjuvant-Specific Induction of Immunosuppressive Cells Open
Purpose: We questioned whether the vaccine adjuvant combination of TLR-7 ligand agonist, imiquimod, with granulocyte macrophage colony-stimulating factor (GM-CSF) would result in enhanced dendritic cell recruitment and activation wi…
View article: Data from Dendritic Cell–Activating Vaccine Adjuvants Differ in the Ability to Elicit Antitumor Immunity Due to an Adjuvant-Specific Induction of Immunosuppressive Cells
Data from Dendritic Cell–Activating Vaccine Adjuvants Differ in the Ability to Elicit Antitumor Immunity Due to an Adjuvant-Specific Induction of Immunosuppressive Cells Open
Purpose: We questioned whether the vaccine adjuvant combination of TLR-7 ligand agonist, imiquimod, with granulocyte macrophage colony-stimulating factor (GM-CSF) would result in enhanced dendritic cell recruitment and activation wi…
View article: Supplementary Figure 1 from Dendritic Cell–Activating Vaccine Adjuvants Differ in the Ability to Elicit Antitumor Immunity Due to an Adjuvant-Specific Induction of Immunosuppressive Cells
Supplementary Figure 1 from Dendritic Cell–Activating Vaccine Adjuvants Differ in the Ability to Elicit Antitumor Immunity Due to an Adjuvant-Specific Induction of Immunosuppressive Cells Open
PDF file, 86KB, The administration of anti-Gr-1 and anti-CD25 mAb can deplete MDSC and Treg cells respectively.
View article: Supplementary Table 2 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Supplementary Table 2 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity Open
PDF file - 65KB, Bacterial sequence homologies for IGFBP-2 C-terminus.
View article: Supplementary Table 2 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Supplementary Table 2 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity Open
PDF file - 65KB, Bacterial sequence homologies for IGFBP-2 C-terminus.
View article: Supplementary Table 1 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Supplementary Table 1 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity Open
PDF file - 15KB, Primer sequences and PCR conditions for the indicated construct.
View article: Data from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Data from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity Open
Immunization against self-tumor antigens can induce T-regulatory cells, which inhibit proliferation of type I CD4+ T-helper (TH1) and CD8+ cytotoxic T cells. Type I T cells are required for potent antitumor…
View article: Supplementary Table 1 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Supplementary Table 1 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity Open
PDF file - 15KB, Primer sequences and PCR conditions for the indicated construct.
View article: Data from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Data from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity Open
Immunization against self-tumor antigens can induce T-regulatory cells, which inhibit proliferation of type I CD4+ T-helper (TH1) and CD8+ cytotoxic T cells. Type I T cells are required for potent antitumor…
View article: Supplementary Table 4 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Supplementary Table 4 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity Open
PDF file - 51KB, Human protein sequence homologies for IGFBP-2 C-terminus.
View article: Supplementary Table 3 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Supplementary Table 3 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity Open
PDF file - 50KB, Human protein sequence homologies for IGFBP-2 N-terminus.
View article: Supplementary Table 3 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Supplementary Table 3 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity Open
PDF file - 50KB, Human protein sequence homologies for IGFBP-2 N-terminus.
View article: Supplementary Table 4 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Supplementary Table 4 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity Open
PDF file - 51KB, Human protein sequence homologies for IGFBP-2 C-terminus.
View article: Lower respiratory tract microbiome composition and community interactions in smokers
Lower respiratory tract microbiome composition and community interactions in smokers Open
The lung microbiome impacts on lung function, making any smoking-induced changes in the lung microbiome potentially significant. The complex co-occurrence and co-avoidance patterns between the bacterial taxa in the lower respiratory tract …
View article: Lower respiratory tract microbiome composition and community interactions in smokers
Lower respiratory tract microbiome composition and community interactions in smokers Open
The lung microbiome impacts lung function, making any smoking-induced changes in the lung microbiome potentially significant. The complex co-occurrence and co-avoidance patterns between the bacterial taxa in the LRT microbiome were explore…
View article: Lower respiratory tract microbiome composition and community interactions in smokers
Lower respiratory tract microbiome composition and community interactions in smokers Open
The lung microbiome impacts lung function, making any smoking-induced changes in the lung microbiome potentially significant. The complex co-occurrence and co-avoidance patterns between the bacterial taxa in the LRT microbiome were explore…
View article: Multi-Run Concrete Autoencoder to Identify Prognostic lncRNAs for 12 Cancers
Multi-Run Concrete Autoencoder to Identify Prognostic lncRNAs for 12 Cancers Open
Background: Long non-coding RNA plays a vital role in changing the expression profiles of various target genes that lead to cancer development. Thus, identifying prognostic lncRNAs related to different cancers might help in developing canc…
View article: Multi-run Concrete Autoencoder to Identify Prognostic lncRNAs for 12 Cancers
Multi-run Concrete Autoencoder to Identify Prognostic lncRNAs for 12 Cancers Open
Long non-coding RNA plays a vital role in changing the expression profiles of various target genes that leads to cancer development. Thus, identifying prognostic lncRNAs related to different cancers might help in developing cancer therapy.…
View article: Sarcoidosis or Cancer? That Is the Question
Sarcoidosis or Cancer? That Is the Question Open
View article: Assessment of Disparities Associated With a Crisis Standards of Care Resource Allocation Algorithm for Patients in 2 US Hospitals During the COVID-19 Pandemic
Assessment of Disparities Associated With a Crisis Standards of Care Resource Allocation Algorithm for Patients in 2 US Hospitals During the COVID-19 Pandemic Open
In this cohort study of adult patients admitted to a COVID-19 unit at 2 US hospitals, there was no association of race or ethnicity with the priority score underpinning the resource allocation policy. Despite this finding, any policy to gu…
View article: Sarcoidosis or cancer? That is the question
Sarcoidosis or cancer? That is the question Open
Sarcoidosis is a granulomatous inflammatory disease of unknown etiology. Sarcoid like granuloma may develop concurrently or following cancer. Detection of granuloma in mediastinal lymph nodes biopsy in patient with pulmonary nodules may be…
View article: Activity of the growth hormone‐releasing hormone antagonist MIA602 and its underlying mechanisms of action in sarcoidosis‐like granuloma
Activity of the growth hormone‐releasing hormone antagonist MIA602 and its underlying mechanisms of action in sarcoidosis‐like granuloma Open
Objectives Growth hormone‐releasing hormone (GHRH) is a potent stimulator of growth hormone (GH) secretion from the pituitary gland. Although GHRH is essential for the growth of immune cells, the regulatory effects of its antagonist in gra…
View article: Effects of Tocilizumab in COVID-19 patients: a cohort study
Effects of Tocilizumab in COVID-19 patients: a cohort study Open
Background: Due to the lack of proven therapies, we evaluated the effects of early administration of tocilizumab for COVID-19. By inhibition of the IL-6 receptor, tocilizumab may help to mitigate the hyperinflammatory response associated w…
View article: Effects of Tocilizumab in COVID-19 patients: a cohort study
Effects of Tocilizumab in COVID-19 patients: a cohort study Open
Background: Due to the lack of proven therapies, we evaluated the effects of early administration of tocilizumab for COVID-19. By inhibition of the IL-6 receptor, tocilizumab may help to mitigate the hyperinflammatory response associated w…