Gregory Foran
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View article: Investigating the role of BDNF in modulation of APP β‐cleavage and BACE1 subcellular distribution
Investigating the role of BDNF in modulation of APP β‐cleavage and BACE1 subcellular distribution Open
Background Brain‐derived neurotrophic factor (BDNF) is an important mediator of neuronal function and survival. BDNF levels are elevated in post‐exercise serum extracted from human donors, and we and others have shown that both post‐exerci…
View article: Human Diseases Associated with Notch Signalling: Lessons from Drosophila melanogaster
Human Diseases Associated with Notch Signalling: Lessons from Drosophila melanogaster Open
Drosophila melanogaster has been used as a model system to identify and characterize genetic contributions to development, homeostasis, and to investigate the molecular determinants of numerous human diseases. While there exist many differ…
View article: Notch signalling plays a role in patterning the ventral mesoderm during early embryogenesis in Drosophila melanogaster
Notch signalling plays a role in patterning the ventral mesoderm during early embryogenesis in Drosophila melanogaster Open
Notch signaling is a critical regulator of multiple developmental processes through its ability to control gene expression, and thereby influence cell fate specification and cell proliferation, through direct cell-cell communication. Altho…
View article: Playback Cloning: Simple, Reversible, Cost-effective Cloning for the Combinatorial Assembly of Complex Expression Constructs
Playback Cloning: Simple, Reversible, Cost-effective Cloning for the Combinatorial Assembly of Complex Expression Constructs Open
With advancements in multicomponent molecular biological tools, the need for versatile, rapid and cost-effective cloning that enables successful combinatorial assembly of DNA plasmids of interest is becoming increasingly important. Unfortu…
View article: Notch signalling plays a role in patterning the ventral meso-derm during early embryogenesis in <i>Drosophila melanogaster</i>
Notch signalling plays a role in patterning the ventral meso-derm during early embryogenesis in <i>Drosophila melanogaster</i> Open
Notch signalling is a critical regulator of multiple developmental processes through its ability to control gene expression and thereby influence cell fate specification and cell proliferation through direct cell-cell communication. Althou…
View article: Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping
Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping Open
The Notch receptor is a pleiotropic signaling protein that translates intercellular ligand interactions into changes in gene expression via the nuclear localization of the Notch intracellular Domain (NICD). Using a combination of immunohis…
View article: Molluscan RXR Transcriptional Regulation by Retinoids in a Drosophila CNS Organ Culture System
Molluscan RXR Transcriptional Regulation by Retinoids in a Drosophila CNS Organ Culture System Open
Retinoic acid, the active metabolite of Vitamin A, is important for the appropriate development of the nervous system (e.g., neurite outgrowth) as well as for cognition (e.g., memory formation) in the adult brain. We have shown that many o…
View article: Interleukin-6 Treatment Results in GLUT4 Translocation and AMPK Phosphorylation in Neuronal SH-SY5Y Cells
Interleukin-6 Treatment Results in GLUT4 Translocation and AMPK Phosphorylation in Neuronal SH-SY5Y Cells Open
Interleukin-6 (IL-6) is a pleiotropic cytokine that can be released from the brain during prolonged exercise. In peripheral tissues, exercise induced IL-6 can result in GLUT4 translocation and increased glucose uptake through AMPK activati…