Gregory G. King
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View article: Supine hyperinflation and expiratory flow limitation are associated with respiratory arousals and nocturnal hypoventilation in COPD
Supine hyperinflation and expiratory flow limitation are associated with respiratory arousals and nocturnal hypoventilation in COPD Open
Introduction Subjective sleep disturbance is common in chronic obstructive pulmonary disease (COPD) and is related to hyperinflation when supine and tidal expiratory flow limitation (EFL). We hypothesised that abnormalities in supine lung …
View article: Potential sites for Asparagopsis spp. cultivation on Australia’s East Coast in 2100
Potential sites for Asparagopsis spp. cultivation on Australia’s East Coast in 2100 Open
Asparagopsis , a red macroalgae native to Australia’s East Coast (10° S, 142° E to 44 ° S, 154° E), has shown the potential to reduce livestock methane emissions by up to 98%, facilitating climate change mitigation. Ensemble species distri…
View article: Resting Hyperinflation Predicts Incremental Shuttle Walk Distance in Chronic Obstructive Pulmonary Disease
Resting Hyperinflation Predicts Incremental Shuttle Walk Distance in Chronic Obstructive Pulmonary Disease Open
Rationale: The incremental shuttle walk test (ISWT) correlates closely with peak oxygen uptake in COPD and relates to important outcomes such as mortality, response to treatment and hospital readmission. Despite this, there is limit…
View article: Interpreting respiratory oscillometry in adults with asthma or COPD: Findings of an international Delphi study
Interpreting respiratory oscillometry in adults with asthma or COPD: Findings of an international Delphi study Open
Background Respiratory oscillometry measures the physiological effort and mechanics of moving air in and out of the lungs during normal breathing. It provides complementary information to spirometry. Uncertainty regarding the interpretatio…
View article: Implementation of a preoperative exercise programme in lung cancer resection: protocol for a mixed-methods study
Implementation of a preoperative exercise programme in lung cancer resection: protocol for a mixed-methods study Open
Introduction Preoperative exercise training is recommended, when feasible, for people undergoing resection for lung cancer and has been shown to reduce the risk of postoperative pulmonary complications and improve preoperative exercise cap…
View article: Predicting clinical exacerbations using respiratory oscillometry during home telemonitoring of patients taking medium/high dose asthma treatment
Predicting clinical exacerbations using respiratory oscillometry during home telemonitoring of patients taking medium/high dose asthma treatment Open
Rationale Strategies for asthma management need better tools to identify risk of exacerbations. In this prospective observational study, we investigated the utility of day-to-day variability in lung mechanics, measured by home telemonitore…
View article: The effect of expiratory flow limitation on supine persistent hyperinflation in COPD: a prospective observational study
The effect of expiratory flow limitation on supine persistent hyperinflation in COPD: a prospective observational study Open
Introduction COPD is characterised by airflow obstruction, expiratory airway collapse and closure causing expiratory flow limitation (EFL) and hyperinflation. Supine posture may worsen ventilatory function in COPD, which may cause hyperinf…
View article: An example of ventilatory limitation during cardiopulmonary exercise testing in a patient with <scp>COPD</scp>
An example of ventilatory limitation during cardiopulmonary exercise testing in a patient with <span>COPD</span> Open
A 64‐year‐old obese gentleman attended for further evaluation of ongoing dyspnoea in the context of a previous diagnosis of moderate COPD treated with dual long‐acting bronchodilators. A cardiopulmonary exercise test (CPET) was performed, …
View article: Improving asthma outcomes: Clinicians’ perspectives on peripheral airways
Improving asthma outcomes: Clinicians’ perspectives on peripheral airways Open
View article: Early Progressive Peripheral Airway Dysfunction after Allogeneic Haematopoietic Stem Cell Transplantation is associated with chronic Graft vs Host disease not BOS-0p
Early Progressive Peripheral Airway Dysfunction after Allogeneic Haematopoietic Stem Cell Transplantation is associated with chronic Graft vs Host disease not BOS-0p Open
Background Current spirometric-based criteria for diagnosis of bronchiolitis obliterans syndrome (BOS) may miss early peripheral airway disease associate with disease onset. Multiple breath washout (MBW) and oscillometry offer improved sen…
View article: Editorial: Physiological phenotyping in respiratory diseases: New approaches
Editorial: Physiological phenotyping in respiratory diseases: New approaches Open
EDITORIAL article Front. Physiol., 09 February 2023Sec. Clinical and Translational Physiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1098839
View article: Relationship between concavity of the flow-volume loop and small airway measures in smokers with normal spirometry
Relationship between concavity of the flow-volume loop and small airway measures in smokers with normal spirometry Open
View article: Fixed Airflow Obstruction in Asthma: A Problem of the Whole Lung Not of Just the Airways
Fixed Airflow Obstruction in Asthma: A Problem of the Whole Lung Not of Just the Airways Open
Asthma with irreversible or fixed airflow obstruction (FAO) is a severe clinical phenotype that is difficult to treat and is associated with an accelerated decline in lung function and excess morbidity. There are no current treatments to r…
View article: The effect of oxygen and carbon dioxide cross-sensitivity sensor error in the Eco Medics Exhalyzer D device on measures of conductive and acinar airway function
The effect of oxygen and carbon dioxide cross-sensitivity sensor error in the Eco Medics Exhalyzer D device on measures of conductive and acinar airway function Open
Introduction The multiple breath nitrogen washout (MBNW) test provides important clinical information in obstructive airways diseases. Recently, a significant cross-sensitivity error in the O 2 and CO 2 sensors of a widely used commercial …
View article: Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’
Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’ Open
Oxygen is a life‐saving therapy but, when given inappropriately, may also be hazardous. Therefore, in the acute medical setting, oxygen should only be given as treatment for hypoxaemia and requires appropriate prescription, monitoring and …
View article: Clinical significance and applications of oscillometry
Clinical significance and applications of oscillometry Open
Recently, “Technical standards for respiratory oscillometry” was published, which reviewed the physiological basis of oscillometric measures and detailed the technical factors related to equipment and test performance, quality assurance an…
View article: Toward explaining fixed airflow obstruction in asthma
Toward explaining fixed airflow obstruction in asthma Open
View article: Controlled<i>versus</i>free breathing for multiple-breath nitrogen washout in asthma
Controlled<i>versus</i>free breathing for multiple-breath nitrogen washout in asthma Open
The lack of comparability in indices of ventilation heterogeneity between free- and controlled-breathing MBNW protocols is confirmed in asthma https://bit.ly/3lmri4A.
View article: Normal limits for oscillometric bronchodilator responses and relationships with clinical factors
Normal limits for oscillometric bronchodilator responses and relationships with clinical factors Open
Introduction We aimed to determine normal thresholds for positive bronchodilator responses for oscillometry in an Australian general population sample aged ≥40 years, to guide clinical interpretation. We also examined relationships between…
View article: Within-session variability as quality control for oscillometry in health and disease
Within-session variability as quality control for oscillometry in health and disease Open
Oscillometry is increasingly adopted in respiratory clinics, but many recommendations regarding measurement settings and quality control remain subjective. The aim of this study was to investigate the optimal number of measurements and acc…
View article: Phenotyping of Asthma Exacerbations Using Day-to-Day Variability in Oscillometry Measures in Children
Phenotyping of Asthma Exacerbations Using Day-to-Day Variability in Oscillometry Measures in Children Open
View article: Dynamic compliance and reactance in older non-smokers with asthma and fixed airflow obstruction
Dynamic compliance and reactance in older non-smokers with asthma and fixed airflow obstruction Open
In older non-smokers with asthma and fixed airflow obstruction, X5 measured by oscillometry reflects dynamic rather than static compliance. Distinguishing between dynamic and static compliance is important as they are …
View article: Airway smooth muscle cells from severe asthma patients with fixed airflow obstruction are responsive to steroid and bronchodilator treatment<i>in vitro</i>
Airway smooth muscle cells from severe asthma patients with fixed airflow obstruction are responsive to steroid and bronchodilator treatment<i>in vitro</i> Open
Airway smooth muscle cells from severe asthma patients with FAO respond to β2-agonists and corticosteroids in vitro, and at a level similar to mild asthmatics. Intrinsic dysfunction of these signalling pathways is unli…
View article: Long-term variability of oscillatory impedance in stable obstructive airways disease
Long-term variability of oscillatory impedance in stable obstructive airways disease Open
FOT parameters have good long-term repeatability in patients with stable obstructive airways disease, facilitating its ability to detect sensitive changes in airways disease. Novel cut-off values presented may help determine clinically …
View article: To recline is to relax? Not when you have COPD!
To recline is to relax? Not when you have COPD! Open
Orthopnoea, the worsening of dyspnoea when supine, is due to more than just supine hyperinflation and altered lung mechanics, but also to increased respiratory drivehttps://bit.ly/34gGTtr
View article: Controlled<i>versus</i>free breathing for multiple breath nitrogen washout in healthy adults
Controlled<i>versus</i>free breathing for multiple breath nitrogen washout in healthy adults Open
Multiple breath nitrogen washout (MBNW) quantifies ventilation heterogeneity. Two distinct protocols are currently used for MBNW testing: “controlled breathing”, with targeted tidal volume ( V T ) and respiratory rate (RR); and “free breat…
View article: Caution in interpretation of abnormal carbon monoxide diffusion capacity in COVID-19 patients
Caution in interpretation of abnormal carbon monoxide diffusion capacity in COVID-19 patients Open
Reduced KCO in discharged patients with COVID-19 suggests persistent abnormalities in gas exchange. Further research is required to understand why.
View article: Higher body mass index is associated with increased lung stiffness and less airway obstruction in individuals with asthma and fixed airflow obstruction
Higher body mass index is associated with increased lung stiffness and less airway obstruction in individuals with asthma and fixed airflow obstruction Open
Higher body mass index (BMI) is associated with less severe airway obstruction in older asthma patients with fixed airflow obstruction. This is potentially mediated through BMI-related mechanisms that increase lung stiffness (i.e.
View article: Technical standards for respiratory oscillometry: test loads for calibration and verification
Technical standards for respiratory oscillometry: test loads for calibration and verification Open
It has been brought to our attention that there is ambiguity in the ERS technical standards for respiratory oscillometry, specifically regarding the use of test loads for calibration and verification. Here it is worth making a distinction …
View article: Table of Contents
Table of Contents Open