Gesine Hansen
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View article: Carsten Schmidt-Weber 2624
Carsten Schmidt-Weber 2624 Open
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View article: Incidence and outcomes of patients admitted to emergency departments with urinary tract infections in Denmark: a retrospective cohort study
Incidence and outcomes of patients admitted to emergency departments with urinary tract infections in Denmark: a retrospective cohort study Open
UTIs are a common cause of hospitalization and represent a substantial healthcare burden in Denmark. Older age, male sex, comorbidities, and severe clinical presentations were key predictors of admission and mortality.
View article: Rigid and Flexible Bronchoscopy for Foreign Body Removal in Children: Complications, Risk Factors and Anesthetic Management
Rigid and Flexible Bronchoscopy for Foreign Body Removal in Children: Complications, Risk Factors and Anesthetic Management Open
Background Foreign body (FB) aspiration is a typical emergency experienced by young children and associated with significant morbidity and mortality unless diagnosed early and treated adequately. Data on anesthetic management, applicabilit…
View article: Genotype and transcript processing of the tumour necrosis factor receptor TNFRSF1A in epithelial cells: implications for survival in cystic fibrosis
Genotype and transcript processing of the tumour necrosis factor receptor TNFRSF1A in epithelial cells: implications for survival in cystic fibrosis Open
Supported by the German Ministry for Education and Research (BMBF) (82DZL009B1 to MAM and 82DZL002A1, to GH, BT, AMD, FS) and the Mukoviszidose Institut gGmbH (MI-2002, to LN, AMD, FS).
View article: Epigenetic training of human bronchial epithelium cells by repeated rhinovirus infections
Epigenetic training of human bronchial epithelium cells by repeated rhinovirus infections Open
Background Humans are subjected to various environmental stressors (bacteria, viruses, pollution) throughout life. As such, an inherent relationship exists between the effect of these exposures with age. The impact of these environmental s…
View article: Blood transcriptome profiling reveals distinct gene networks induced by mRNA vaccination against COVID‐19
Blood transcriptome profiling reveals distinct gene networks induced by mRNA vaccination against COVID‐19 Open
Messenger RNA (mRNA) vaccines represent a new class of vaccines that has been shown to be highly effective during the COVID‐19 pandemic and that holds great potential for other preventative and therapeutic applications. While it is known t…
View article: Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits
Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits Open
Elderly individuals have higher disease susceptibility and lower vaccine responsiveness, highlighting the need to better comprehend the aging immune system and its clinical associations. Here we conducted a deep immune profiling study of 5…
View article: Impact of elexacaftor/tezacaftor/ivacaftor therapy on lung clearance index and magnetic resonance imaging in children with cystic fibrosis and one or two<i>F508del</i>alleles
Impact of elexacaftor/tezacaftor/ivacaftor therapy on lung clearance index and magnetic resonance imaging in children with cystic fibrosis and one or two<i>F508del</i>alleles Open
Background We recently demonstrated that elexacaftor/tezacaftor/ivacaftor (ETI) improves the lung clearance index (LCI) and abnormalities in lung morphology detected by magnetic resonance imaging (MRI) in adolescent and adult patients with…
View article: Sensor macrophages derived from human induced pluripotent stem cells to assess pyrogenic contaminations in parenteral drugs
Sensor macrophages derived from human induced pluripotent stem cells to assess pyrogenic contaminations in parenteral drugs Open
Ensuring the safety of parenteral drugs before injection into patients is of utmost importance. New regulations around the globe and the need to refrain from using animals however, have highlighted the need for new cell sources to be used …
View article: PREFUL MRI for Monitoring Perfusion and Ventilation Changes after Elexacaftor-Tezacaftor-Ivacaftor Therapy for Cystic Fibrosis: A Feasibility Study
PREFUL MRI for Monitoring Perfusion and Ventilation Changes after Elexacaftor-Tezacaftor-Ivacaftor Therapy for Cystic Fibrosis: A Feasibility Study Open
Purpose To assess the feasibility of monitoring the effects of elexacaftor-tezacaftor-ivacaftor (ETI) therapy on lung ventilation and perfusion in people with cystic fibrosis (CF), using phase-resolved functional lung (PREFUL) MRI. Materia…
View article: An integrated molecular risk score early in life for subsequent childhood asthma risk
An integrated molecular risk score early in life for subsequent childhood asthma risk Open
Background Numerous children present with early wheeze symptoms, yet solely a subgroup develops childhood asthma. Early identification of children at risk is key for clinical monitoring, timely patient‐tailored treatment, and preventing ch…
View article: Pulmonary Alveolar Proteinosis and new therapeutic concepts
Pulmonary Alveolar Proteinosis and new therapeutic concepts Open
Pulmonary alveolar proteinosis (PAP) is an umbrella term used to refer to a pulmonary syndrome which is characterized by excessive accumulation of surfactant in the lungs of affected individuals. In general, PAP is a rare lung disease affe…
View article: Systems biology analysis reveals distinct molecular signatures associated with immune responsiveness to the BNT162b COVID-19 vaccine
Systems biology analysis reveals distinct molecular signatures associated with immune responsiveness to the BNT162b COVID-19 vaccine Open
German Center for Infection Research, German Center for Lung Research, German Research Foundation, Excellence Strategy EXC 2155 "RESIST" and European Regional Development Fund.
View article: Multiparametric Cardiovascular MRI Assessment of Post-COVID Syndrome in Children in Comparison to Matched Healthy Individuals
Multiparametric Cardiovascular MRI Assessment of Post-COVID Syndrome in Children in Comparison to Matched Healthy Individuals Open
Background Post-COVID syndrome (PCS) can adversely affect the quality of life of patients and their families. In particular, the degree of cardiac impairment in children with PCS is unknown. Objective The aim of this study was to identify …
View article: 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma
17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma Open
Rationale: The strongest genetic risk factor for childhood-onset asthma, the 17q21 locus, is associated with increased viral susceptibility and disease-promoting processes.Objectives: To identify biological targets underlying the escalated…
View article: Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia
Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia Open
Background Macrophages have recently become attractive therapeutics in cancer immunotherapy. The potential of macrophages to infiltrate and influence solid malignancies makes them promising targets for the chimeric antigen receptor (CAR) t…
View article: Increased breath naphthalene in children with asthma and wheeze of the All Age Asthma Cohort (ALLIANCE)
Increased breath naphthalene in children with asthma and wheeze of the All Age Asthma Cohort (ALLIANCE) Open
Exhaled breath contains numerous volatile organic compounds (VOCs) known to be related to lung disease like asthma. Its collection is non-invasive, simple to perform and therefore an attractive method for the use even in young children. We…
View article: Spirometric and anthropometric improvements in response to elexacaftor/tezacaftor/ivacaftor depending on age and lung disease severity
Spirometric and anthropometric improvements in response to elexacaftor/tezacaftor/ivacaftor depending on age and lung disease severity Open
Introduction: Triple-combination cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy with elexacaftor/tezacaftor/ivacaftor (ETI) was introduced in August 2020 in Germany for people with CF (pwCF) ≥12 years (yrs.) o…
View article: Optimal treatment of the underlying aetiology is the most effective antimicrobial stewardship for chronic respiratory disease: a lesson learned from cystic fibrosis
Optimal treatment of the underlying aetiology is the most effective antimicrobial stewardship for chronic respiratory disease: a lesson learned from cystic fibrosis Open
AMS in chronic lung disease can be challenging. Causal treatment of treatable traits may be the most successful AMS strategy for patients with any chronic pulmonary disease and should be brought into focus. https://bit.ly/3ptrmV8.
View article: Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells
Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells Open
A single population of interferon-regulatory factor 8 (Irf8)-dependent conventional dendritic cell (cDC type1) is considered to be responsible for both immunogenic and tolerogenic responses depending on the surrounding cytokine milieu . He…
View article: Differential effects of ELX/TEZ/IVA on organ-specific CFTR function in two patients with the rare CFTR splice mutations c.273+1G>A and c.165-2A>G
Differential effects of ELX/TEZ/IVA on organ-specific CFTR function in two patients with the rare CFTR splice mutations c.273+1G>A and c.165-2A>G Open
Introduction: Evidence for the efficiency of highly-effective triple-CFTR-modulatory therapy with elexacaftor/tezacaftor/ivacaftor (ETI), either demonstrated in clinical trials or by in vitro testing, is lacking for about 10% of people wit…
View article: Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort
Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort Open
Test-retest reliability and validity of the ASSESS score was confirmed in the All Age Asthma Cohort. In children aged 6 to 11 years, internal consistency was inferior compared with that in older patients with asthma; however, test validity…
View article: Minimal clinically important difference for impulse oscillometry in adults with asthma
Minimal clinically important difference for impulse oscillometry in adults with asthma Open
Background Impulse oscillometry (IOS) allows an effort-independent evaluation of small airway function in asthma. Unfortunately, well-determined minimal clinically important differences (MCIDs) for IOS measures are lacking. Here, we provid…
View article: Changes in cystic fibrosis transmembrane conductance regulator protein expression prior to and during elexacaftor-tezacaftor-ivacaftor therapy
Changes in cystic fibrosis transmembrane conductance regulator protein expression prior to and during elexacaftor-tezacaftor-ivacaftor therapy Open
Background: Defects in expression, maturation or function of the epithelial membrane glycoprotein CFTR are causative for the progressive disease cystic fibrosis. Recently, molecular therapeutics that improve CFTR maturation and functional …