Gregory T. Jones
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View article: Considerations for study design and analysis for ethically and culturally safe DNA methylation research in Aotearoa New Zealand
Considerations for study design and analysis for ethically and culturally safe DNA methylation research in Aotearoa New Zealand Open
View article: What’s counted counts: the implications of underrepresentation for the application of epigenetic clocks in diverse populations
What’s counted counts: the implications of underrepresentation for the application of epigenetic clocks in diverse populations Open
DNA methylation (DNAm) has been touted as a potential unified marker of the contributions of both inherited and environmental factors on an individual’s health. Changes in DNAm have been associated with several chronic diseases and mortali…
View article: P05.05.A INTEGRATED MULTI-OMICS AND MULTI-SPECTRAL PROFILING OF PLASMA EXTRACELLULAR VESICLES REVEALS HIGHLY ACCURATE LIQUID BIOPSY BIOMARKERS FOR GLIOMA DIAGNOSIS.
P05.05.A INTEGRATED MULTI-OMICS AND MULTI-SPECTRAL PROFILING OF PLASMA EXTRACELLULAR VESICLES REVEALS HIGHLY ACCURATE LIQUID BIOPSY BIOMARKERS FOR GLIOMA DIAGNOSIS. Open
BACKGROUND Liquid biopsy approaches are revolutionising the management of patients with extracranial solid tumours. However, the techniques investigated have not been effective in neuro-oncology. There is therefore an urgent need to develo…
View article: Lipoprotein(a) concentrations and secondary outcomes following first-time acute coronary syndrome: The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS)
Lipoprotein(a) concentrations and secondary outcomes following first-time acute coronary syndrome: The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS) Open
Elevated Lp(a) concentrations are associated with secondary events following ACS. Further research is needed to define optimal thresholds for increased risk and explore ethnic-specific implications for secondary prevention.
View article: INVESTIGATION OF A LIQUID BIOPSY EXTRACELLULAR VESICLE BIOMARKER FOR BRAIN TUMOURS – THE ROLE OF A COMMON INflAMMATORY PATHWAY
INVESTIGATION OF A LIQUID BIOPSY EXTRACELLULAR VESICLE BIOMARKER FOR BRAIN TUMOURS – THE ROLE OF A COMMON INflAMMATORY PATHWAY Open
AIMS Extracellular vesicles are secreted by all cells and small extracellular vesicles (EVs) 50-200nm have been inves- tigated in body fluids as a potential liquid biopsy for glioblastoma. Previous studies have identified an inflam- matory si…
View article: POS1156 FACTORS ASSOCIATED WITH TIME TO DIAGNOSIS OF AXIAL SPONDYLOARTHRITIS IN A UK POPULATION. A CROSS-SECTIONAL OBSERVATIONAL STUDY
POS1156 FACTORS ASSOCIATED WITH TIME TO DIAGNOSIS OF AXIAL SPONDYLOARTHRITIS IN A UK POPULATION. A CROSS-SECTIONAL OBSERVATIONAL STUDY Open
View article: Pre-treatment DNA methylome and transcriptome profiles correlate with melanoma response to anti-PD1 immunotherapy
Pre-treatment DNA methylome and transcriptome profiles correlate with melanoma response to anti-PD1 immunotherapy Open
Successful immune checkpoint inhibitor (ICI) therapy occurs in only a fraction of melanoma patients, and yet all patients are susceptible to potentially serious ICI-related side-effects. No current biomarkers robustly predict ICI treatment…
View article: Association between lipoprotein(a), <i>LPA</i> genetic risk score, aortic valve disease, and subsequent major adverse cardiovascular events
Association between lipoprotein(a), <i>LPA</i> genetic risk score, aortic valve disease, and subsequent major adverse cardiovascular events Open
Aims Cohort studies have demonstrated associations between calcific aortic valve disease (CAVD) and Lp(a). As Lp(a) is almost entirely genetically determined, in this study, we aim to determine whether Lp(a), when predicted from genetic da…
View article: A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure
A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure Open
Background & Methods In this study, a novel restriction enzyme (RE) digestion-based droplet digital polymerase chain reaction (ddPCR) assay was designed for cg005575921 within the AHRR gene body and compared with matching results obtained …
View article: Use of an ultrasound picture archiving and communication system to answer research questions: Description of data cleaning methods
Use of an ultrasound picture archiving and communication system to answer research questions: Description of data cleaning methods Open
Introduction/Purpose Ultrasound picture archiving and communication system (PACS) databases are useful for quality improvement and clinical research but frequently contain free text that is not easily readable. Here, we present a method to…
View article: A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure.
A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure. Open
Background & Methods: In this study, a novel restriction enzyme (RE) digestion-based droplet digital polymerase chain reaction (ddPCR) assay was designed for cg005575921 within the AHRR gene body and compared with matching results obtained…
View article: Pre-Treatment DNA Methylome and Transcriptome Profiles Correlate with Melanoma Response to Anti-Pd1 Immunotherapy
Pre-Treatment DNA Methylome and Transcriptome Profiles Correlate with Melanoma Response to Anti-Pd1 Immunotherapy Open
View article: Gaps in current methods to detect polymorphic CpGs from Illumina Infinium human methylation microarrays and exploring their potential impact in multi-EWAS analyses
Gaps in current methods to detect polymorphic CpGs from Illumina Infinium human methylation microarrays and exploring their potential impact in multi-EWAS analyses Open
DNA methylation (DNAm) epigenome-wide association studies (EWAS) have been performed on diverse ethnicities to discover novel biomarkers associated with various diseases, such as cancers, autoimmune diseases, and neurological disorders. Ho…
View article: Outcomes of patients with early calcific aortic valve disease detected by clinically indicated echocardiography
Outcomes of patients with early calcific aortic valve disease detected by clinically indicated echocardiography Open
Aims Previous studies have demonstrated relatively slow rates of progression of early calcific aortic valve disease (CAVD), which encompasses aortic sclerosis (ASc) and mild aortic stenosis (AS). The potential evolution to clinically signi…
View article: Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target Open
View article: A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure
A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure Open
Background & Methods: In this study, a novel restriction enzyme (RE) digestion-based droplet digital polymerase chain reaction (ddPCR) assay was designed for cg005575921 within the AHRR gene body and compared with matching results obtained…
View article: Association between lipoprotein(a),<i>LPA</i>genetic risk score, aortic valve disease, and subsequent major adverse cardiovascular events
Association between lipoprotein(a),<i>LPA</i>genetic risk score, aortic valve disease, and subsequent major adverse cardiovascular events Open
Background Cohort studies have demonstrated associations between calcific aortic valve disease (CAVD) and Lp(a). As Lp(a) is almost entirely genetically determined, with the increasing clinical availability of genetic information, we aimed…
View article: Association Between Lipoprotein(A), LPA Genetic Risk Score, Aortic Valve Disease, and Subsequent Major Adverse Cardiovascular Events
Association Between Lipoprotein(A), LPA Genetic Risk Score, Aortic Valve Disease, and Subsequent Major Adverse Cardiovascular Events Open
View article: Supplementary Data from Extent and Patterns of <i>MGMT</i> Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres
Supplementary Data from Extent and Patterns of <i>MGMT</i> Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres Open
Supplementary Figures S1-S6; Supplementary Table S1.
View article: Data from Extent and Patterns of <i>MGMT</i> Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres
Data from Extent and Patterns of <i>MGMT</i> Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres Open
Purpose: Quantitative methylation-specific tests suggest that not all cells in a glioblastoma with detectable promoter methylation of the O6-methylguanine DNA methyltransferase (MGMT) gene carry a methylated MGMT allel…
View article: Supplementary Data from Extent and Patterns of <i>MGMT</i> Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres
Supplementary Data from Extent and Patterns of <i>MGMT</i> Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres Open
Supplementary Figures S1-S6; Supplementary Table S1.
View article: Data from Extent and Patterns of <i>MGMT</i> Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres
Data from Extent and Patterns of <i>MGMT</i> Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres Open
Purpose: Quantitative methylation-specific tests suggest that not all cells in a glioblastoma with detectable promoter methylation of the O6-methylguanine DNA methyltransferase (MGMT) gene carry a methylated MGMT allel…
View article: DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight
DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight Open
Background Individuals born very low birthweight (VLBW) are at increased risk of impaired cardiovascular and respiratory function in adulthood. To identify markers to predict future risk for VLBW individuals, we analyzed DNA methylation at…
View article: Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity
Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity Open
Background: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic…
View article: Additional file 7 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight
Additional file 7 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight Open
Additional file 7: Table S3. Differentially methylated regions (DMRs) that were significant (FDR adj-p<0.05), with DMRs in neonatal samples on the first worksheet and DMRs identified in adult samples on the second worksheet.
View article: Additional file 4 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight
Additional file 4 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight Open
Additional file 4: Table S2. Full list of 16407 CpGs with methylation that differed between VLBW cases and controls after adjusting for false discovery rate (Benjamini-Hochberg FDR adj-p<0.05).
View article: Gaps in current methods to detect polymorphic CpGs from Illumina Infinium human methylation microarrays and exploring their potential impact in multi-EWAS analyses
Gaps in current methods to detect polymorphic CpGs from Illumina Infinium human methylation microarrays and exploring their potential impact in multi-EWAS analyses Open
DNA methylation (DNAm) epigenome-wide association studies (EWAS) have been performed on diverse ethnicities to discover novel biomarkers associated with various diseases, such as cancers, autoimmune diseases, and neurological disorders. Ho…
View article: Use of an ultrasound picture archiving and communication system (PACS) to answer research questions: description of data cleaning methods
Use of an ultrasound picture archiving and communication system (PACS) to answer research questions: description of data cleaning methods Open
Background Ultrasound picture archiving and communication system (PACS) databases are useful for quality improvement and clinical research, but frequently contain free text that is not easily readable. Here, we present a method to extract …
View article: DNA Methylation Patterns At Birth Predict Health Outcomes In Young Adults Born Very Low Birthweight
DNA Methylation Patterns At Birth Predict Health Outcomes In Young Adults Born Very Low Birthweight Open
Background Individuals born very low birthweight (VLBW) are at increased risk of impaired cardiovascular and respiratory function in adulthood. To identify markers to predict future risk for VLBW individuals, we analysed DNA methylation at…
View article: Therapeutic knockdown of miR-320 improves deteriorated cardiac function in a pre-clinical model of non-ischemic diabetic heart disease
Therapeutic knockdown of miR-320 improves deteriorated cardiac function in a pre-clinical model of non-ischemic diabetic heart disease Open