Giancarlo Logroscino
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View article: <scp>MRI</scp> ‐ <scp>DTI</scp> Biomarkers Along the Continuum of Behavioral Variant Frontotemporal Dementia
<span>MRI</span> ‐ <span>DTI</span> Biomarkers Along the Continuum of Behavioral Variant Frontotemporal Dementia Open
Background We investigated whether diffusion tensor imaging (DTI) and atlas‐based volumetry (ABV) could track specific patterns of brain white matter (WM) microstructure and gray matter (GM) volumes in behavioral variant frontotemporal dem…
View article: Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer’s disease
Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer’s disease Open
This joint Position Paper, developed by the Italian Expert Panel on Alzheimer convened by the Italian Society of Neurology with participation from multiple scientific societies, outlines strategic guidelines for reorganizing the patient jo…
View article: Incidence and Prevalence of Frontotemporal Dementia
Incidence and Prevalence of Frontotemporal Dementia Open
Importance Comprehensive incidence and prevalence rates of frontotemporal dementia are currently not available. Objective To estimate the incidence and prevalence of frontotemporal dementia and its clinical variants in the overall populati…
View article: Reliable New Biomarkers of Mitochondrial Oxidative Stress and Neuroinflammation in Cerebrospinal Fluid and Plasma from Alzheimer’s Disease Patients: A Pilot Study
Reliable New Biomarkers of Mitochondrial Oxidative Stress and Neuroinflammation in Cerebrospinal Fluid and Plasma from Alzheimer’s Disease Patients: A Pilot Study Open
Mitochondrial oxidative stress and neuroinflammation are involved in the onset and progression of Alzheimer’s disease (AD). Novel reliable, circulating biomarkers related to these processes were searched in cerebrospinal fluid (CSF) and pl…
View article: Mental Health and ESG: An Econometric Analysis of Environmental, Social, and Governance Impacts
Mental Health and ESG: An Econometric Analysis of Environmental, Social, and Governance Impacts Open
Background Whereas Environmental, Social, and Governance (ESG) issues and mental well-being have each been studied previously, their combined impacts have rarely been analyzed, and certainly not from a regional perspective where economic a…
View article: Underdetection of neurocognitive disorders in Southern Italy: Evidence from the Salento region
Underdetection of neurocognitive disorders in Southern Italy: Evidence from the Salento region Open
This study highlights the critical gaps in detecting neurocognitive disorders, particularly in older adults and prodromal stages such as minor neurocognitive disorders, where early intervention could yield the greatest benefits. The findin…
View article: Global, regional and national population attributable fraction of potentially modifiable risk factors for dementia in the adult population: an analysis using global health databases
Global, regional and national population attributable fraction of potentially modifiable risk factors for dementia in the adult population: an analysis using global health databases Open
Introduction Approximately 45% of dementia cases are potentially modifiable; however, their population attributable fraction (PAF) may vary according to sociodeterminants and geographical regions. Thus, this descriptive, ecologic study aim…
View article: Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia
Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia Open
Objective The myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically def…
View article: International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative
International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative Open
BACKGROUND: Socio-cognitive assessment in neurocognitive disorders (NCDs) is rare in clinical practice and no consensus exists as to a uniform operationalization of socio-cognitive measures for neurocognitive disorders in memory clinics. T…
View article: Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview
Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview Open
INTRODUCTION Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further cha…
View article: Understanding barriers and optimizing socio‐cognitive assessment in the diagnosis of neurocognitive disorders
Understanding barriers and optimizing socio‐cognitive assessment in the diagnosis of neurocognitive disorders Open
Harmonized neuropsychological assessment for neurocognitive disorders (NCDs) is an urgent priority in clinics. Neuropsychology assessments in NCDs seldom include tests exploring social cognitive skills. In 2022, we launched the SIGNATURE i…
View article: Occupational exposures, biomarkers and neurodegenerative diseases
Occupational exposures, biomarkers and neurodegenerative diseases Open
Brain aging is marked by progressive changes and characterized at cellular, and organ dysfunction occurring in several areas of the brain. The main processes have all in common the deposition of proteins that the brain cannot metabolize an…
View article: Structural covariance network patterns linked to neuropsychiatric symptoms in biologically defined Alzheimer's disease: Insights from the mild behavioral impairment checklist
Structural covariance network patterns linked to neuropsychiatric symptoms in biologically defined Alzheimer's disease: Insights from the mild behavioral impairment checklist Open
Background: The frequent presentation of Alzheimer's disease (AD) with neuropsychiatric symptoms (NPS) in the context of normal or minimally-impaired cognitive function led to the concept of Mild Behavioral Impairment (MBI). While MBI's im…
View article: Predicting survival rate by plasma biomarkers and clinical variables in syndromes associated with frontotemporal lobar degeneration
Predicting survival rate by plasma biomarkers and clinical variables in syndromes associated with frontotemporal lobar degeneration Open
INTRODUCTION Modeling the survival rate in syndromes associated with frontotemporal lobar degeneration (FTLD) is essential to assess disease trajectories. METHODS In 262 patients with FTLD, we considered plasma neurofilament light chain (N…
View article: Altered Brain-Ventricle Coupling Modes Over Alzheimer’s Disease Progression Detected With fMRI
Altered Brain-Ventricle Coupling Modes Over Alzheimer’s Disease Progression Detected With fMRI Open
The origins of resting-state functional MRI (rsfMRI) signal fluctuations remain debated. Recent evidence shows coupling between global cortical rsfMRI signals and cerebrospinal fluid inflow in the fourth ventricle, increasing during sleep …
View article: Cognitive reserve linked to network-specific brain-ventricle coupling modes
Cognitive reserve linked to network-specific brain-ventricle coupling modes Open
Despite showing significant impact in cognitive preservation, the relationship between brain activity captured with functional Magnetic Resonance Imaging (fMRI) in gray matter and ventricular cerebrospinal fluid dynamics remains poorly und…
View article: International Initiative for Harmonization of Plasma Neurofilament light chain NfL clinical reporting in neurodegenerative diseases
International Initiative for Harmonization of Plasma Neurofilament light chain NfL clinical reporting in neurodegenerative diseases Open
Background The quantification of neurofilament light chain (NfL) in blood and cerebrospinal fluid (CSF) has proved useful in many contexts, for the diagnosis and prognosis of various neurological disorders. There is, however, a diversity o…
View article: Mild cognitive impairment and early Alzheimer's disease eligibility for disease modification therapies in a tertiary centre for cognitive disorders: A simultaneous real‐word study on aducanumab and lecanemab
Mild cognitive impairment and early Alzheimer's disease eligibility for disease modification therapies in a tertiary centre for cognitive disorders: A simultaneous real‐word study on aducanumab and lecanemab Open
Background and purpose The Food and Drug Administration approved two disease‐modifying treatments (DMTs) for Alzheimer's disease (AD), aducanumab and lecanemab, with limited clinical impact but significant biomarker changes. Identifying su…
View article: Treatment of Obstructive Sleep Apnea in patients with Alzheimer’s Disease: role of Continuous Positive Airway Pressure therapy
Treatment of Obstructive Sleep Apnea in patients with Alzheimer’s Disease: role of Continuous Positive Airway Pressure therapy Open
Purpose of Review Obstructive Sleep Apnea (OSA) is a frequent comorbidity in patients with Alzheimer’s Disease (AD). This narrative review critically examines current evidence on the relationship between OSA and AD, discussing their shared…
View article: Nocturnal sleep dynamics alterations in the early stages of behavioral variant frontotemporal dementia
Nocturnal sleep dynamics alterations in the early stages of behavioral variant frontotemporal dementia Open
Study Objectives Sleep disorders have been recognized as an integral component of the clinical syndrome in several neurodegenerative diseases, including Alzheimer’s disease (AD). However, limited data exist for rarer types of neurodegenera…
View article: Changing Epidemiology of Neurological Diseases in Africa
Changing Epidemiology of Neurological Diseases in Africa Open
EDITORIAL
View article: Predictors of Care Home Admission and Survival Rate in Patients With Syndromes Associated With Frontotemporal Lobar Degeneration in Europe
Predictors of Care Home Admission and Survival Rate in Patients With Syndromes Associated With Frontotemporal Lobar Degeneration in Europe Open
In FTLD-associated syndromes, survival rates differ according to clinical features and geography. The SPS was able to predict prognosis at individual patient level with an accuracy of ∼80% and may help to improve patient stratification in …
View article: Temporal gamma tACS and auditory stimulation affect verbal memory in healthy adults
Temporal gamma tACS and auditory stimulation affect verbal memory in healthy adults Open
Research suggests a potential of gamma oscillation entrainment for enhancing memory in Alzheimer's disease and healthy subjects. Gamma entrainment can be accomplished with oscillatory electrical, but also sensory stimulation. However, comp…