Explanipedia

Frequency of cannabis use and symptoms of anxiety and depression: a cross-sectional analysis of the Colorado cannabis users health cohort Open

Christine M. Steeger, Poojashree Tandukar, Karin F. Hoth, Mark S. Aloia, Fred Wamboldt , et al. · 2025

Background Cannabis is commonly used as a self-prescribed treatment for anxiety and depression, but few studies have evaluated these associations using both validated mental health scales and biological cannabinoid markers. This study aime…

Maternal Smoking and CC-16: Implications for Lung Development and COPD Across the Lifespan Open

Joselyn Rojas, Rosa Faner, Chia-Ying Chiu, J.T. Kue, Yun Zhang , et al. · 2025

Maternal smoking was linked to reduced circulating and airway CC16 in COPD patients, controls, and a preclinical murine COPD model. In human adults, lower CC16 correlated with accelerated lung function decline and emphysema progression, wh…

Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification Open

Paul S. de Vries, Matthew P. Conomos, Kuldeep Singh, Christopher Nicholson, Deepti Jain , et al. · 2025

MON-457 Plasma Cortisol and Salivary Cortisone Are Clinically Useful for Managing Adrenal Insufficiency Open

Julia G Kallet, Whitaker Hover, A. Krein, James Crooks, Gregory L. Kinney , et al. · 2025

Disclosure: J.G. Kallet: None. W. Hover: None. A.D. Krein: None. J.L. Crooks: None. G.L. Kinney: None. M.F. Slovick: None. U. Christians: None. B. Schniedewind: None. S. Majka: None. M.T. McDermott: None. E.A. Regan: None. Adrenal insuffic…

Use of the Wnt/β-catenin Activator Lithium Is Associated with Less Emphysema Open

Divay Chandra, Kassandra Allbright, Gregory L. Kinney, Yisha Li, Russell Bowler , et al. · 2025

Rationale Emphysema is defined by progressive alveolar destruction and impaired tissue repair, with diminished Wnt/β-catenin signaling implicated in its pathogenesis. Preclinical studies suggest that lithium, a pharmacologic activator of W…

The Prevalence of Type 1 Diabetes in Hispanic/Latino Populations in the United States: Findings from the Hispanic Community Health Study/Study of Latinos. Open

Gregory L. Kinney, Kendra A. Young, Molly M. Lamb, Trevor J. Orchard, Jianwen Cai , et al. · 2025

Estimates of type 1 diabetes in "All Hispanic" and Mexican-American populations were reported in 2013 using National Health and Nutrition Examination Survey (NHANES) data collected between 1999 and 2010, but this study did not examine suff…

Proteomic biomarkers of emphysema-predominant and non-emphysema-predominant chronic obstructive pulmonary disease Open

Yuhang Zhang, Peter J. Castaldi, Russell P. Bowler, Katherine Pratte, Gregory L. Kinney , et al. · 2025

B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort Open

Matthew Moll, Zhonghui Xu, Adel Boueiz, Min Hyung Ryu, Edwin K. Silverman , et al. · 2025

Rationale Cigarette smoking (CS) impairs B-cell function and antibody production, increasing infection risk. The impact of e-cigarette use ('vaping') and combined CS and vaping ('dual-use') on B-cell activity is unclear. Objective To exami…

Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants Open

Kruthika Iyer, Shoa L. Clarke, Rodrigo Guarischi‐Sousa, Ketrin Gjoni, Adam S. Heath , et al. · 2025

Background Genome‐wide association studies have identified several hundred susceptibility single nucleotide variants for coronary artery disease (CAD). Despite single nucleotide variant‐based genome‐wide association studies improving our u…

Relationships between Bronchodilator Responsiveness, a Copd Polygenic Risk Score, and Copd Progression Open

Spyridon Fortis, Alejandro P. Comellas, Russell P. Bowler, Craig P. Hersh, Dawn L. DeMeo , et al. · 2025

Impact of prenatal exposure to delta 9‐tetrahydrocannabinol and cannabidiol on birth size and postnatal growth trajectories Open

Brianna F. Moore, Noel T. Mueller, Wei Perng, Katherine A. Sauder, Emily T. Hébert , et al. · 2024

Summary Background Prenatal exposure to cannabis (or more specifically, delta 9‐tetrahydrocannabinol [Δ9‐THC]) has been consistently linked to low birthweight. Animal models further show that Δ9‐THC is associated with rapid postnatal growt…

Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes Open

Delnaz Roshandel, Athina Spiliopoulou, Stuart J. McGurnaghan, Andrii Iakovliev, Debby Lipschutz , et al. · 2024

Identified genetic loci for C-peptide and age at diagnosis (AAD) in individuals with type 1 diabetes (T1D) explain only a small proportion of their variation. Here, we aimed to perform large metagenome-wide association studies (GWAS) of C-…

Plasma Proteomic Markers of Iron and Risk of Diabetes in a Cohort of African American and White American Current and Former Smokers Open

Baqiyyah Conway, Katherine Pratte, Russell P. Bowler, Kendra A. Young, Gregory L. Kinney , et al. · 2024

Higher body iron stores is associated with increased diabetes risk among both NHB and NHW people. Unsuspected elevated iron stores may increase diabetes risk in NHB patients and should be monitored.

Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes Open

Delnaz Roshandel, Athina Spiliopoulou, Stuart J. McGurnaghan, Andrii Iakovliev, Debby Lipschutz , et al. · 2024

Identified genetic loci for C-peptide and age at diagnosis (AAD) in individuals with type 1 diabetes (T1D) explain only a small proportion of their variation. Here, we aimed to perform large metagenome-wide association studies (GWAS) of C-…

Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes Open

Delnaz Roshandel, Athina Spiliopoulou, Stuart J. McGurnaghan, Andrii Iakovliev, Debby Lipschutz , et al. · 2024

Identified genetic loci for C-peptide and age at diagnosis (AAD) in individuals with type 1 diabetes (T1D) explain only a small proportion of their variation. Here, we aimed to perform large metagenome-wide association studies (GWAS) of C-…

Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes Open

Delnaz Roshandel, Athina Spiliopoulou, Stuart J. McGurnaghan, Andrii Iakovliev, Debby Lipschutz , et al. · 2024

Identified genetic loci for C-peptide and age at diagnosis (AAD) in individuals with type 1 diabetes (T1D) explain only a small proportion of their variation. Here, we aimed to perform large meta–genome-wide association studies (GWAS) of C…

Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies Open

Matthew Moll, Julian Hecker, John Platig, Jingzhou Zhang, Auyon Ghosh , et al. · 2024

B cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort Open

Matthew Moll, Zhonghui Xu, Adel Boueiz, Min Hyung Ryu, Edwin K. Silverman , et al. · 2024

Rationale Cigarette smoking (CS) impairs B cell function and antibody production, increasing infection risk. The impact of e-cigarette use (’vaping’) and combined CS and vaping (’dual-use’) on B cell activity is unclear. Objective To exami…

Epidemiologic Features of Recovery From SARS-CoV-2 Infection Open

Elizabeth C. Oelsner, Yifei Sun, Pallavi Balte, Norrina B. Allen, Howard Andrews , et al. · 2024

Importance: Persistent symptoms and disability following SARS-CoV-2 infection, known as post-COVID-19 condition or "long COVID," are frequently reported and pose a substantial personal and societal burden. Objective: To determine time to r…

8205 Within day Symptoms Of Adrenal Insufficiency Predict Reduced Quality Of Life And Adrenal Crises In 712 MyAI Registry Participants Open

Julia G Kallet, Whitaker Hover, A. Krein, Melissa Lowe, Michal F Slovick , et al. · 2024

Disclosure: J.G. Kallet: None. W. Hover: None. A. Krein: None. M. Lowe: None. M.F. Slovick: None. G. Kinney: None. S. Majka: None. K. Warren: None. S. Watts: None. M.T. McDermott: None. E.A. Regan: None. Multiple studies have shown reduced…

8555 Hourly Assessment Of Symptoms In 16 Adrenal Insufficiency Patients Correlates With AddiQoL Open

Julia G Kallet, Whitaker Hover, A. Krein, Michal F Slovick, Susan M. Majka , et al. · 2024

Disclosure: J.G. Kallet: None. W. Hover: None. A. Krein: None. M.F. Slovick: None. S. Majka: None. G.L. Kinney: None. S. Watts: None. M.T. McDermott: None. E.A. Regan: None. Background: A major challenge in the treatment of adrenal insuffi…

Childhood exposure to cannabidiol and lung function: A pilot study Open

Nolan Younoszai, Christopher Hollander, Gregory L. Kinney, Katharine L. Hamlington, Jost Klawitter , et al. · 2024

Cannabidiol (CBD) use has increased substantially in recent years, particularly since the legalization of hemp-derived CBD through the United States 2018 Agriculture Improvement Act. In the same year, the World Health Organization indicate…

Association of PHACTR1 with Coronary Artery Calcium Differs by Sex and Cigarette Smoking Open

Kirsten Voorhies, Kendra A. Young, Fang‐Chi Hsu, Merry‐Lynn McDonald, Sanghun Lee , et al. · 2024

Background: Coronary artery calcium (CAC) is a marker of subclinical atherosclerosis and is a complex heritable trait with both genetic and environmental risk factors, including sex and smoking. Methods: We performed genome-wide associatio…

Epidemiologic Features of Recovery From SARS-CoV-2 Infection Open

Elizabeth C. Oelsner, Yifei Sun, Pallavi Balte, Norrina B. Allen, Howard Andrews , et al. · 2024

Importance Persistent symptoms and disability following SARS-CoV-2 infection, known as post–COVID-19 condition or “long COVID,” are frequently reported and pose a substantial personal and societal burden. Objective To determine time to rec…

Rheumatoid arthritis and changes on spirometry by smoking status in two prospective longitudinal cohorts Open

Keigo Hayashi, Gregory C McDermott, Pierre‐Antoine Juge, Matthew Moll, Michael H. Cho , et al. · 2024

Objective To compare longitudinal changes in spirometric measures between patients with rheumatoid arthritis (RA) and non-RA comparators. Methods We analysed longitudinal data from two prospective cohorts: the UK Biobank and COPDGene. Spir…

Chronic Obstructive Pulmonary Disease Exacerbations Increase the Risk of Subsequent Cardiovascular Events: A Longitudinal Analysis of the COPDGene Study Open

Han‐Mo Yang, Min Hyung Ryu, Vincent J. Carey, Gregory L. Kinney, John E. Hokanson , et al. · 2024

Background Cardiovascular disease (CVD) is the most important comorbidity in patients with chronic obstructive pulmonary disease (COPD). COPD exacerbations not only contribute to COPD progression but may also elevate the risk of CVD. This …

Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes Open

Matthew Moll, Julian Hecker, John Platig, Jingzhou Zhang, Auyon Ghosh , et al. · 2024

Rationale Genetic variants and gene expression predict risk of chronic obstructive pulmonary disease (COPD), but their effect on COPD heterogeneity is unclear. Objectives Define high-risk COPD subtypes using both genetics (polygenic risk s…

A novel application of data‐consistent inversion to overcome spurious inference in genome‐wide association studies Open

Negar Janani, Kendra A. Young, Gregory L. Kinney, Matthew Strand, John E. Hokanson , et al. · 2024

The genome‐wide association studies (GWAS) typically use linear or logistic regression models to identify associations between phenotypes (traits) and genotypes (genetic variants) of interest. However, the use of regression with the additi…

Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design Open

E.C. Oelsner, Amar Krishnaswamy, P.P Balte, Nicholas B. Allen, Tamara Ali , et al. · 2024

The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) is a national prospective study of adults comprising 14 established US prospective cohort studies. Starting as early as 1971, investigators in the C4R cohort studies have coll…

Trajectory modeling of cannabis use over 30 years identifies five unique longitudinal patterns Open

Amy Mahar, Michael P. Bancks, Stephen Sidney, Jared P. Reis, Gregory L. Kinney · 2023

Gregory L. Kinney YOU? Author Swipe