Gregory L. Medlock
YOU?
Author Swipe
View article: 377. Impact of VE303, a Defined Bacterial Consortium, on Antimicrobial Resistant Gene Prevalence in Patients with <i>Clostridioides difficile</i> Infection (CDI)
377. Impact of VE303, a Defined Bacterial Consortium, on Antimicrobial Resistant Gene Prevalence in Patients with <i>Clostridioides difficile</i> Infection (CDI) Open
Background Repeated antibiotic treatment for recurrent CDI (rCDI) may promote the colonization of antimicrobial resistant (AR) microbes, which can worsen CDI outcomes and increase the risk of drug-resistant infections. Fecal microbiota pro…
View article: 2521. VE707, a Defined Live Biotherapeutic Product for Prevention of Infection by Multidrug-Resistant Gram-Negative Bacteria
2521. VE707, a Defined Live Biotherapeutic Product for Prevention of Infection by Multidrug-Resistant Gram-Negative Bacteria Open
Background Infections with multidrug-resistant organisms (MDRO) are increasing at an alarming rate in hospitals worldwide. MDRO infections are often preceded by asymptomatic intestinal colonization and growth by the MDRO. Treatments such a…
View article: A computational model of Pseudomonas syringae metabolism unveils a role for branched-chain amino acids in Arabidopsis leaves colonization.
A computational model of Pseudomonas syringae metabolism unveils a role for branched-chain amino acids in Arabidopsis leaves colonization. Open
Bacterial pathogens adapt their metabolism to the plant environment to successfully colonize their hosts. In our efforts to uncover the metabolic pathways that contribute to the colonization of Arabidopsis thaliana by Pseudomo…
View article: A computational model of<i>Pseudomonas syringae</i>metabolism unveils the role of branched-chain amino acids in virulence expression at the early stages of Arabidopsis colonization
A computational model of<i>Pseudomonas syringae</i>metabolism unveils the role of branched-chain amino acids in virulence expression at the early stages of Arabidopsis colonization Open
Leaf mesophyll-colonizing bacterial pathogens infect their plant hosts by adjusting their metabolism to the leaf mesophyll environment. Soon after the inoculation of naïve, susceptible plants, the model bacterial pathogen Pseudomonas syrin…
View article: <i>Megasphaera</i>in the stool microbiota is negatively associated with diarrheal cryptosporidiosis
<i>Megasphaera</i>in the stool microbiota is negatively associated with diarrheal cryptosporidiosis Open
Background The protozoan parasites in the Cryptosporidium genus cause both acute diarrheal disease and subclinical (i.e. non-diarrheal) disease. It is unclear if the microbiota can influence the manifestation of diarrhea during a Cryptospo…
View article: Publisher Correction: MEMOTE for standardized genome-scale metabolic model testing
Publisher Correction: MEMOTE for standardized genome-scale metabolic model testing Open
View article: MEMOTE for standardized genome-scale metabolic model testing
MEMOTE for standardized genome-scale metabolic model testing Open
View article: gregmedlock/ssl_ensembles: Publication Release
gregmedlock/ssl_ensembles: Publication Release Open
Release to get ready for publication of the manuscript. This release will be linked in the manuscript via Zenodo.
View article: Comparative analyses of parasites with a comprehensive database of genome-scale metabolic models
Comparative analyses of parasites with a comprehensive database of genome-scale metabolic models Open
Protozoan parasites cause diverse diseases with large global impacts. Research on the pathogenesis and biology of these organisms is limited by economic and experimental constraints. Accordingly, studies of one parasite are frequently extr…
View article: Functional Anabolic Network Analysis of Human-associated<i>Lactobacillus</i>Strains
Functional Anabolic Network Analysis of Human-associated<i>Lactobacillus</i>Strains Open
Members of the Lactobacillus genus are frequently utilized in the probiotic industry with many species conferring demonstrated health benefits; however, these effects are largely strain-dependent. We designed a method called PROTEAN (Proba…
View article: Medusa: software to build and analyze ensembles of genome-scale metabolic network reconstructions
Medusa: software to build and analyze ensembles of genome-scale metabolic network reconstructions Open
Uncertainty in the structure and parameters of networks is ubiquitous across computational biology. In constraint-based reconstruction and analysis of metabolic networks, this uncertainty is present both during the reconstruction of networ…
View article: A novel mouse model of<i>Campylobacter jejuni</i>enteropathy and diarrhea
A novel mouse model of<i>Campylobacter jejuni</i>enteropathy and diarrhea Open
Campylobacter infections are among the leading bacterial causes of diarrhea and of ‘environmental enteropathy’ (EE) and growth failure worldwide. However, the lack of an inexpensive small animal model of enteric disease with Campylobacter …
View article: Metabolic mechanisms of interaction within a defined gut microbiota
Metabolic mechanisms of interaction within a defined gut microbiota Open
Metabolic interactions among species are ubiquitous in nature, and the fitness costs and benefits they impose often reinforce and stabilize them over time. These interactions are of particular importance in the human gut, where they have f…
View article: Influential parameters for the analysis of intracellular parasite metabolomics
Influential parameters for the analysis of intracellular parasite metabolomics Open
Metabolomics is increasingly popular for the study of many pathogens. For the malaria parasite, Plasmodium falciparum , both targeted and untargeted metabolite detection has improved our understanding of pathogenesis, host-parasite interac…
View article: Novel co-culture plate enables growth dynamic-based assessment of contact-independent microbial interactions
Novel co-culture plate enables growth dynamic-based assessment of contact-independent microbial interactions Open
Interactions between microbes are central to the dynamics of microbial communities. Understanding these interactions is essential for the characterization of communities, yet challenging to accomplish in practice. There are limited availab…
View article: Cross-modulation of pathogen-specific pathways enhances malnutrition during enteric co-infection with Giardia lamblia and enteroaggregative Escherichia coli
Cross-modulation of pathogen-specific pathways enhances malnutrition during enteric co-infection with Giardia lamblia and enteroaggregative Escherichia coli Open
Diverse enteropathogen exposures associate with childhood malnutrition. To elucidate mechanistic pathways whereby enteric microbes interact during malnutrition, we used protein deficiency in mice to develop a new model of co-enteropathogen…
View article: Systems-level metabolism of the altered Schaedler flora, a complete gut microbiota
Systems-level metabolism of the altered Schaedler flora, a complete gut microbiota Open
The altered Schaedler flora (ASF) is a model microbial community with both in vivo and in vitro relevance. Here we provide the first characterization of the ASF community in vitro, independent of a murine host. We compared the functional g…
View article: Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype
Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype Open
View article: Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain
Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain Open