Grégory Merlen
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View article: Engineered human liver based on pullulan-dextran hydrogel promotes mice survival after liver failure
Engineered human liver based on pullulan-dextran hydrogel promotes mice survival after liver failure Open
Liver tissue engineering approaches aim to support drug testing, assistance devices, or transplantation. However, their suitability for clinical application remains unsatisfactory. Herein, we demonstrate the beneficial and biocompatible us…
View article: The bile acid receptor TGR5 and cholestasis
The bile acid receptor TGR5 and cholestasis Open
During liver injury and cholestasis, the mechanisms allowing the organ to protect itself with the aim of maintaining biliary homeostasis are not completely understood. Central to their biological roles, bile acids (BAs) and their receptors…
View article: Deletion of serine palmitoyl transferase 2 in hepatocytes impairs ceramide/sphingomyelin balance, prevents obesity and leads to liver damage in mice
Deletion of serine palmitoyl transferase 2 in hepatocytes impairs ceramide/sphingomyelin balance, prevents obesity and leads to liver damage in mice Open
Ceramides (Cer) have been shown as lipotoxic inducers, which disturb numerous cell signalling pathways especially insulin signalling pathway leading to metabolic disorders such as type 2 diabetes. In this study, we aimed to determine the r…
View article: Bile acid-receptor TGR5 deficiency worsens liver injury in alcohol-fed mice by inducing intestinal microbiota dysbiosis
Bile acid-receptor TGR5 deficiency worsens liver injury in alcohol-fed mice by inducing intestinal microbiota dysbiosis Open
Excessive chronic alcohol intake can induce liver disease. Bile acids are molecules produced by the liver and can modulate disease severity. We addressed the specific role of TGR5, a bile-acid receptor. We found that TGR5 deficiency worsen…
View article: TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload
TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload Open
Through multiple in vivo experimental approaches in mice, together with a patient study, this work brings some new light on the relationships between biliary homeostasis, gallbladder function, and liver protection. We showed that hepatic b…
View article: Bile Acid pool composition and Gallbladder function are controlled by TGR5 to protect the liver against Bile Acid overload
Bile Acid pool composition and Gallbladder function are controlled by TGR5 to protect the liver against Bile Acid overload Open
Backgrounds & Aims As the bile acid (BA) pool composition is of major impact on liver pathophysiology, we studied its regulation by the BA receptor TGR5, promoting hepatoprotection against BA overload. Methods WT, total and hepato-specific…
View article: TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function
TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function Open
Objective We explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled receptor highly expressed in biliary epithelial cells, protects the liver against BA overload through the regulation of biliary epithelium permeability. D…
Upregulation of Krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia Open
The liver is a highly vascularized organ receiving a dual input of oxygenated blood from the hepatic artery and portal vein. The impact of decreased blood flow on glucose metabolism and how hepatocytes could adapt to this restrictive envir…