Gregory Naylor
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View article: A Phase 1a/1b Study of Fostroxacitabine Bralpamide (Fostrox) Monotherapy in Hepatocellular Carcinoma and Solid Tumor Liver Metastases
A Phase 1a/1b Study of Fostroxacitabine Bralpamide (Fostrox) Monotherapy in Hepatocellular Carcinoma and Solid Tumor Liver Metastases Open
The phase 1a/1b monotherapy study of fostrox, in patients with liver tumors, showed a tumor selective effect in the liver and that 40 mg QD for 5 days in 21-day cycles is safe and tolerable. Safety and preliminary efficacy in patients with…
View article: Caspase-resistant ROCK1 expression prolongs survival of <i>Eµ-Myc</i> B cell lymphoma mice
Caspase-resistant ROCK1 expression prolongs survival of <i>Eµ-Myc</i> B cell lymphoma mice Open
Apoptosis is characterized by membrane blebbing and apoptotic body formation. Caspase cleavage of ROCK1 generates an active fragment that promotes actin–myosin-mediated contraction and membrane blebbing during apoptosis. Expression of casp…
View article: Caspase-resistant ROCK1 expression prolongs survival of<i>Eµ-Myc</i>B cell lymphoma mice
Caspase-resistant ROCK1 expression prolongs survival of<i>Eµ-Myc</i>B cell lymphoma mice Open
Apoptosis is characterized by membrane blebbing and apoptotic body formation. Caspase cleavage of ROCK1 generates an active fragment that promotes actin-myosin mediated contraction and membrane blebbing during apoptosis. Expression of casp…
View article: Impact of the COVID-19 pandemic on patients with hepatocellular carcinoma in the West of Scotland: a cohort study
Impact of the COVID-19 pandemic on patients with hepatocellular carcinoma in the West of Scotland: a cohort study Open
Objective The COVID-19 pandemic had an undoubted impact on the provision of elective and emergency cancer care, including the diagnosis and management of patients with hepatocellular carcinoma (HCC). Our aim was to determine the effects of…
View article: Immunogenic Death of Hepatocellular Carcinoma Cells in Mice Expressing Caspase-Resistant ROCK1 Is Not Replicated by ROCK Inhibitors
Immunogenic Death of Hepatocellular Carcinoma Cells in Mice Expressing Caspase-Resistant ROCK1 Is Not Replicated by ROCK Inhibitors Open
The morphological changes during apoptosis help facilitate “immunologically silent” cell death. Caspase cleavage of the ROCK1 kinase results in its activation, which drives the forceful contraction of apoptotic cells. We previously showed …
View article: Immunogenic cell death in mice expressing caspase-resistant ROCK1 is not replicated by ROCK inhibitors
Immunogenic cell death in mice expressing caspase-resistant ROCK1 is not replicated by ROCK inhibitors Open
The characteristic changes in morphology during apoptosis help facilitate “immunologically-silent” cell death by limiting the release of cellular contents and enabling efficient clearance of apoptotic cell bodies. Caspase-mediated cleavage…
View article: PWE-46 Impact of the COVID-19 pandemic on patients with Hepatocellular Carcinoma in the West of Scotland
PWE-46 Impact of the COVID-19 pandemic on patients with Hepatocellular Carcinoma in the West of Scotland Open
Introduction The COVID-19 pandemic has focused medical resources on acute and critical care, with an impact on patients with chronic illness. Worldwide, HCC surveillance, imaging and clinic follow-up may have been impacted, which is likely…
View article: Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression
Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression Open
Apoptosis is characterized by profound morphological changes, but their physiological purpose is unknown. To characterize the role of apoptotic cell contraction, ROCK1 was rendered caspase non-cleavable (ROCK1nc) by mutating aspartate 1113…
View article: Author response: Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression
Author response: Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Apoptosis is characterized by profound mor…
View article: Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer Open
The myotonic dystrophy–related Cdc42-binding kinases MRCKα and MRCKβ contribute to the regulation of actin–myosin cytoskeleton organization and dynamics, acting in concert with the Rho-associated coiled-coil kinases ROCK1 and ROCK2. The ab…