Gregory P. Priebe
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View article: Single-cell RNA sequencing of lung leukocytes from cystic fibrosis mice after mucosal vaccination reveals differential gene expression in leukocyte subsets and links to dysregulated Th17 responses 4056
Single-cell RNA sequencing of lung leukocytes from cystic fibrosis mice after mucosal vaccination reveals differential gene expression in leukocyte subsets and links to dysregulated Th17 responses 4056 Open
Description Chronic Pseudomonas aeruginosa lung infection poses a significant threat to individuals with cystic fibrosis (CF), yet effective vaccine strategies remain elusive. Our previous work demonstrated that an intranasal (IN) vaccine …
View article: De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen
De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen Open
Bacteria evolving within human hosts encounter selective tradeoffs that render mutations adaptive in one context and deleterious in another. Here, we report that the cystic fibrosis-associated pathogen Burkholderia dolosa overcomes in-huma…
View article: Epinephrine vs Norepinephrine as Initial Treatment in Children With Septic Shock
Epinephrine vs Norepinephrine as Initial Treatment in Children With Septic Shock Open
Importance There is no consensus and wide practice variation in the choice of initial vasoactive agent in children with septic shock. Objective To determine whether receipt of epinephrine compared with norepinephrine as the first vasoactiv…
View article: <i>De novo</i>mutations mediate phenotypic switching in an opportunistic human lung pathogen
<i>De novo</i>mutations mediate phenotypic switching in an opportunistic human lung pathogen Open
Bacteria evolving within human hosts encounter selective tradeoffs that render mutations adaptive in one context and deleterious in another. Here, we report that the cystic fibrosis-associated pathogen Burkholderia dolosa overcomes in-huma…
View article: Cystic Fibrosis Mice Are Highly Susceptible to Repeated Acute Pseudomonas aeruginosa Pneumonia after Intranasal Inoculation
Cystic Fibrosis Mice Are Highly Susceptible to Repeated Acute Pseudomonas aeruginosa Pneumonia after Intranasal Inoculation Open
Cystic fibrosis (CF) is a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) that controls chloride current. A number of different CFTR transgenic mouse lines have been developed and subj…
View article: Stress Ulcer Prophylaxis Versus Placebo—A Blinded Pilot Randomized Controlled Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease
Stress Ulcer Prophylaxis Versus Placebo—A Blinded Pilot Randomized Controlled Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease Open
OBJECTIVES: The routine use of stress ulcer prophylaxis (SUP) in infants with congenital heart disease (CHD) in the cardiac ICU (CICU) is controversial. We aimed to conduct a pilot study to explore the feasibility of performing a subsequen…
View article: Pediatric Ventilator-Associated Events Before and After a Multicenter Quality Improvement Initiative
Pediatric Ventilator-Associated Events Before and After a Multicenter Quality Improvement Initiative Open
Importance Pediatric ventilator-associated events (PedVAEs, defined as a sustained worsening in oxygenation after a baseline period of stability or improvement) are useful for surveillance of complications from mechanical ventilation. It i…
View article: Small-molecule activators of a bacterial signaling pathway inhibit virulence
Small-molecule activators of a bacterial signaling pathway inhibit virulence Open
The Burkholderia genus encompasses multiple human pathogens, including potential bioterrorism agents, that are often extensively antibiotic resistant. The FixLJ pathway in Burkholderia is a two-component system that regulates virulence. Pr…
View article: 254. Genomic diversity of Gram-negative Bacilli from Bloodstream Infections in Hospitalized Children
254. Genomic diversity of Gram-negative Bacilli from Bloodstream Infections in Hospitalized Children Open
Background Gram-negative bloodstream infection (BSI) in hospitalized children is associated with significant morbidity and mortality. It is unclear whether bacterial clonality of isolates during BSI in a unique patient is associated with c…
View article: Comparison of Administrative Database-Derived and Hospital-Derived Data for Monitoring Blood Culture Use in the Pediatric Intensive Care Unit
Comparison of Administrative Database-Derived and Hospital-Derived Data for Monitoring Blood Culture Use in the Pediatric Intensive Care Unit Open
Background Optimizing blood culture practices requires monitoring of culture use. Collecting culture data from electronic medical records can be resource intensive. Our objective was to determine whether administrative data could serve as …
View article: Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice
Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice Open
The Gram-negative pathogen Pseudomonas aeruginosa is a common cause of pneumonia in hospitalized patients. Its increasing antibiotic resistance and widespread occurrence present a pressing need for vaccines.
View article: An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome
An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome Open
Objective To compare clinical outcomes in children with hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) who were managed before and after implementation of an evidence-based guideline (EBG). Methods A mana…
View article: ICE volume 43 issue 6 Cover and Front matter
ICE volume 43 issue 6 Cover and Front matter Open
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View article: Optimizing surveillance for pediatric ventilator-associated events—But are they preventable?
Optimizing surveillance for pediatric ventilator-associated events—But are they preventable? Open
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View article: Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update
Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update Open
The purpose of this document is to highlight practical recommendations to assist acute care hospitals to prioritize and implement strategies to prevent ventilator-associated pneumonia (VAP), ventilator-associated events (VAE), and non-vent…
View article: Multicomponent <i>Pseudomonas aeruginosa</i> vaccines eliciting Th17 cells and functional antibody responses confer enhanced protection against experimental acute pneumonia in mice
Multicomponent <i>Pseudomonas aeruginosa</i> vaccines eliciting Th17 cells and functional antibody responses confer enhanced protection against experimental acute pneumonia in mice Open
The Gram-negative pathogen Pseudomonas aeruginosa is a common cause of pneumonia in hospitalized patients. Its increasing antibiotic resistance and widespread occurrence present a pressing need for vaccines. We previously showed that a P. …
View article: Association of Diagnostic Stewardship for Blood Cultures in Critically Ill Children With Culture Rates, Antibiotic Use, and Patient Outcomes
Association of Diagnostic Stewardship for Blood Cultures in Critically Ill Children With Culture Rates, Antibiotic Use, and Patient Outcomes Open
Multidisciplinary diagnostic stewardship interventions can reduce blood culture and antibiotic use in the PICU. Future work will determine optimal strategies for wider-scale dissemination of diagnostic stewardship in this setting while mon…
View article: Evolution towards Virulence in a <i>Burkholderia</i> Two-Component System
Evolution towards Virulence in a <i>Burkholderia</i> Two-Component System Open
Infections caused by members of the Burkholderia cepacia complex (BCC) are a serious concern for patients with cystic fibrosis (CF) as these bacteria are often resistant to many antibiotics. During long-term infection of CF patients with B…
View article: A Pseudomonas aeruginosa-Derived Particulate Vaccine Protects against P. aeruginosa Infection
A Pseudomonas aeruginosa-Derived Particulate Vaccine Protects against P. aeruginosa Infection Open
Despite numerous efforts to develop an effective vaccine against Pseudomonas aeruginosa, no vaccine has yet been approved for human use. This study investigates the utility of the P. aeruginosa inherently produced polyhydroxyalkanaote (PHA…
View article: Stewardship Intervention to Optimize Central Venous Catheter Utilization in Critically Ill Children
Stewardship Intervention to Optimize Central Venous Catheter Utilization in Critically Ill Children Open
Introduction: We aimed to describe utilization and indication(s) for long-term central venous catheters (CVCs) in a pediatric intensive care unit (PICU) and identify potential strategies to decrease CVC utilization. Methods: We conducted a…
View article: Risk Factors for Pediatric Surgical Site Infection Following Neurosurgical Procedures for Hydrocephalus: A Retrospective Single-Center Cohort Study
Risk Factors for Pediatric Surgical Site Infection Following Neurosurgical Procedures for Hydrocephalus: A Retrospective Single-Center Cohort Study Open
Background Infection is a major complication following cerebral spinal fluid (CSF) diversion procedures for hydrocephalus. However, their pediatric risk factors for surgical site infection (SSI) are currently not well defined. Because SSI …