Gregory S. Sayuk
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View article: Predictors of No-Shows After an Endoscopic Mucosal Resection in Veterans: A Retrospective Analysis
Predictors of No-Shows After an Endoscopic Mucosal Resection in Veterans: A Retrospective Analysis Open
Introduction Endoscopic mucosal resection (EMR) is a common intervention for large colorectal polyps, but its long-term success depends heavily on post-procedure surveillance to detect recurrence. Despite the critical importance of follow-…
View article: General Versus Interventional Gastroenterologists: A Comparative Analysis of Follow-Up Outcomes After Endoscopic Mucosal Resection of Colorectal Polyps
General Versus Interventional Gastroenterologists: A Comparative Analysis of Follow-Up Outcomes After Endoscopic Mucosal Resection of Colorectal Polyps Open
Introduction Colorectal cancer (CRC) represents a major global health burden, significantly impacting mortality rates and healthcare systems worldwide. CRC screening through colonoscopy enables early detection and removal of precancerous p…
View article: Tenapanor Improves Abdominal Symptoms Irrespective of Changes in Complete Spontaneous Bowel Movement Frequency in Adults with Irritable Bowel Syndrome with Constipation
Tenapanor Improves Abdominal Symptoms Irrespective of Changes in Complete Spontaneous Bowel Movement Frequency in Adults with Irritable Bowel Syndrome with Constipation Open
Introduction: Tenapanor is a first-in-class, minimally absorbed intestinal sodium/hydrogen exchanger isoform 3 inhibitor approved by the US Food and Drug Administration for adults with irritable bowel syndrome with constipation (IBS-C). Po…
View article: Plecanatide Improves Abdominal Bloating and Bowel Symptoms of Irritable Bowel Syndrome with Constipation
Plecanatide Improves Abdominal Bloating and Bowel Symptoms of Irritable Bowel Syndrome with Constipation Open
View article: An Overview of the Effects of Tenapanor on Visceral Hypersensitivity in the Treatment of Irritable Bowel Syndrome with Constipation
An Overview of the Effects of Tenapanor on Visceral Hypersensitivity in the Treatment of Irritable Bowel Syndrome with Constipation Open
By improving gastrointestinal motility, decreasing intestinal permeability and inflammation, and normalizing nociception through decreased TRPV1 signaling, tenapanor may reduce visceral hypersensitivity, leading to less abdominal pain in p…
View article: Semaglutide improves metabolic dysfunction‐associated steatohepatitis: A 10‐year retrospective study
Semaglutide improves metabolic dysfunction‐associated steatohepatitis: A 10‐year retrospective study Open
Background and Aims Semaglutide has been studied in patients with metabolic dysfunction‐associated steatohepatitis (MASH) due to potential benefit from weight loss on liver inflammation. However, preclinical studies suggest that MASH impro…
View article: A Percutaneous Endoscopic Colostomy Tube to the Rescue
A Percutaneous Endoscopic Colostomy Tube to the Rescue Open
Percutaneous endoscopic colostomy (PEC) tube placement is a minimally invasive procedure used to treat recurrent colonic pseudo-obstruction, sigmoid volvulus, chronic intractable constipation, and neurogenic bowel. PEC is a viable treatmen…
View article: Raising the Bar in the Management of IBS-C.
Raising the Bar in the Management of IBS-C. Open
View article: Management of Constipation in Hospitalized Patients
Management of Constipation in Hospitalized Patients Open
Constipation is frequently encountered in hospital settings and can have potentially serious consequences yet is often underrecognized and undertreated. Opioid-induced constipation is a common cause of constipation in hospitalized patients…
View article: Editorial: Functional dyspepsia in pregnancy—Distinct approaches to a special population
Editorial: Functional dyspepsia in pregnancy—Distinct approaches to a special population Open
LINKED CONTENT This article is linked to Liu et al papers. To view these articles, visit https://doi.org/10.1111/apt.17534 and https://doi.org/10.1111/apt.17605
View article: Optimizing the Utility of Anorectal Manometry for Diagnosis and Therapy: A Roundtable Review and Recommendations
Optimizing the Utility of Anorectal Manometry for Diagnosis and Therapy: A Roundtable Review and Recommendations Open
Overcoming these challenges with appropriate education, training, collaborative research, and evidence-based guidelines for ARM testing and biofeedback therapy could significantly enhance patient care of anorectal disorders.
View article: Editorial: buspirone for gastroparesis—an intriguing option for a challenging condition
Editorial: buspirone for gastroparesis—an intriguing option for a challenging condition Open
LINKED CONTENT This article is linked to Parkman et al paper. To view this article, visit https://doi.org/10.1111/apt.17479
View article: Nutrient Drink Test to Assess Gastric Accommodation in Cyclic Vomiting Syndrome: Single-blinded Parallel Grouped Prospective Study
Nutrient Drink Test to Assess Gastric Accommodation in Cyclic Vomiting Syndrome: Single-blinded Parallel Grouped Prospective Study Open
To our knowledge, this is the first NDT protocol in CVS evaluating the role of impaired gastric accommodation and hypersensitivity as a possible pathophysiologic mechanism. Findings from this study suggest the presence of gastric hypersens…
View article: The serotonin receptor 3E variant is a risk factor for female IBS-D
The serotonin receptor 3E variant is a risk factor for female IBS-D Open
Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT 3 receptor family. 5-HT 3 Rs are encoded by HTR3 genes and control GI function, an…
View article: A Narrative Review of Irritable Bowel Syndrome with Diarrhea: A Primer for Primary Care Providers
A Narrative Review of Irritable Bowel Syndrome with Diarrhea: A Primer for Primary Care Providers Open
View article: Episodic Memories Among Irritable Bowel Syndrome (IBS) Patients: An Important Aspect of the IBS Symptom Experience
Episodic Memories Among Irritable Bowel Syndrome (IBS) Patients: An Important Aspect of the IBS Symptom Experience Open
Objective: Some IBS patients possess detailed memories of the events surrounding their bowel symptom onset (“episodic memories”). In this exploratory study we sought to: (1) examine memory relationship with gastrointestinal (GI) symptom se…
View article: Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study
Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study Open
We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS. The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depress…
View article: Model for multi‐disciplinary, multi‐institutional virtual learning: The Stanford Esophageal Virtual Collaborative Conference on benign esophageal diseases
Model for multi‐disciplinary, multi‐institutional virtual learning: The Stanford Esophageal Virtual Collaborative Conference on benign esophageal diseases Open
Multi-disciplinary and multi-institutional collaborations are broadly encouraged in medicine, and have assumed an important role with increasing popularity of virtual web-based conferencing during the COVID pandemic, but remain limited wit…
View article: Segmental Colitis Associated With Diverticulosis Masquerading as Polyploid-Appearing Mucosa in the Rectosigmoid Area on Endoscopy and as Focal Thickening on Imaging
Segmental Colitis Associated With Diverticulosis Masquerading as Polyploid-Appearing Mucosa in the Rectosigmoid Area on Endoscopy and as Focal Thickening on Imaging Open
View article: Insights on Disorders of Gut-Brain Interaction.
Insights on Disorders of Gut-Brain Interaction. Open
View article: Symptomatic Pneumoperitoneum After Gastrostomy Tube Placement Managed by Pneumocentesis
Symptomatic Pneumoperitoneum After Gastrostomy Tube Placement Managed by Pneumocentesis Open
Pneumoperitoneum is a known complication of percutaneous endoscopic gastrostomy tube placement that typically resolves spontaneously with conservative management. We describe the case of a 72-year-old man who developed abdominal pain and d…
View article: Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders Open
Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and c…
View article: Editorial: understanding IBS pathophysiology through “converging channels” of research
Editorial: understanding IBS pathophysiology through “converging channels” of research Open
LINKED CONTENT This article is linked to Grover et al papers. To view these articles, visit https://doi.org/10.1111/apt.16591 and https://doi.org/10.1111/apt.16613
View article: The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome
The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome Open
Irritable bowel syndrome (IBS) is a gut‐brain disorder in which symptoms are shaped by serotonin acting centrally and peripherally. The serotonin transporter gene SLC6A4 has been implicated in IBS pathophysiology, but the underlying geneti…
View article: Editorial: felcisetrag—forward movement as a novel prokinetic for gastroparesis
Editorial: felcisetrag—forward movement as a novel prokinetic for gastroparesis Open
LINKED CONTENT This article is linked to Chedid et al paper. To view this article, visit https://doi.org/10.1111/apt.16304
View article: Improved work productivity and health-related quality of life in patients with irritable bowel syndrome with diarrhea receiving eluxadoline following inadequate response to loperamide
Improved work productivity and health-related quality of life in patients with irritable bowel syndrome with diarrhea receiving eluxadoline following inadequate response to loperamide Open
BACKGROUND: Irritable bowel syndrome with diarrhea (IBS-D) is a chronic disorder of gut-brain interaction that negatively affects work productivity and health-related quality of life (HRQOL). IBS-D therapeutic options are limited an…
View article: A237 IMPROVEMENT IN ABDOMINAL SYMPTOMS WITH LINACLOTIDE IN PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH CONSTIPATION: RESULTS FROM A PHASE 3B TRIAL
A237 IMPROVEMENT IN ABDOMINAL SYMPTOMS WITH LINACLOTIDE IN PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH CONSTIPATION: RESULTS FROM A PHASE 3B TRIAL Open
Background Linaclotide (LIN) is a guanylate cyclase-C agonist approved to treat irritable bowel syndrome with constipation (IBS-C) in adults. Abdominal symptoms are important to patients with IBS-C. In a recent Phase 3b study, LIN signific…
View article: Randomized Trial of 2 Delayed-Release Formulations of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation
Randomized Trial of 2 Delayed-Release Formulations of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation Open
INTRODUCTION: Immediate-release (IR) formulation of linaclotide 290 μg improves abdominal pain and constipation (APC) in patients with irritable bowel syndrome (IBS) with constipation. Delayed-release (DR) formulations were developed on th…
View article: S0469 Linaclotide Improves Abdominal Symptoms Regardless of Baseline IBS Symptom Severity: A Post-Hoc Analysis of a Phase 3b Trial
S0469 Linaclotide Improves Abdominal Symptoms Regardless of Baseline IBS Symptom Severity: A Post-Hoc Analysis of a Phase 3b Trial Open
INTRODUCTION: Linaclotide (LIN) is a guanylate cyclase C (GC-C) agonist approved to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). A phase 3b IBS-C study used a novel Abdominal Score (AS…
View article: A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea
A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea Open
Stress is a known trigger for flares of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS); however, this process is not well understood. Here, we find that restraint stress in mice leads to signs of diarrhea, fecal dysbio…