Gregory Simchick
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View article: Validation of Intravoxel Incoherent Motion <scp>MRI</scp> Using Perfused Explanted Human Livers
Validation of Intravoxel Incoherent Motion <span>MRI</span> Using Perfused Explanted Human Livers Open
Purpose Evaluate the feasibility of using perfused explanted human livers for validating intravoxel incoherent motion (IVIM). Methods Eight ( n = 8) explanted livers from deceased donors were obtained. The portal vein and hepatic artery of…
View article: Optimized acquisition for simultaneous intravoxel incoherent motion and <scp>R<sub>2</sub></scp> quantification in the liver
Optimized acquisition for simultaneous intravoxel incoherent motion and <span>R<sub>2</sub></span> quantification in the liver Open
Purpose Design a b ‐value, first‐order motion moment ( M 1 ), and echo time (TE)–optimized data acquisition for simultaneous intravoxel incoherent motion (IVIM) and R 2 quantification in the liver. Methods The b ‐ M 1 ‐optimized (i.e., sin…
View article: Reproducibility of liver <scp>ADC</scp> measurements using first moment optimized diffusion imaging
Reproducibility of liver <span>ADC</span> measurements using first moment optimized diffusion imaging Open
Purpose Cardiac‐induced liver motion can bias liver ADC measurements and compromise reproducibility. The purpose of this work was to enable motion‐robust DWI on multiple MR scanners and assess reproducibility of the resulting liver ADC mea…
View article: Reproducibility of intravoxel incoherent motion quantification in the liver across field strengths and gradient hardware
Reproducibility of intravoxel incoherent motion quantification in the liver across field strengths and gradient hardware Open
Purpose To evaluate reproducibility and interlobar agreement of intravoxel incoherent motion (IVIM) quantification in the liver across field strengths and MR scanners with different gradient hardware. Methods Cramer‐Rao lower bound optimiz…
View article: Practical Application of Multivendor <scp>MRI</scp>‐Based <scp>R2*</scp> Mapping for Liver Iron Quantification at <scp>1.5 T</scp> and <scp>3.0 T</scp>
Practical Application of Multivendor <span>MRI</span>‐Based <span>R2*</span> Mapping for Liver Iron Quantification at <span>1.5 T</span> and <span>3.0 T</span> Open
Background Recent multicenter, multivendor MRI‐based R2* vs. liver iron concentration (LIC) calibrations (i.e., MCMV calibrations) may facilitate broad clinical dissemination of R2*‐based LIC quantification. However, these calibrations are…
View article: Precision of <scp>region of interest</scp>‐based tri‐exponential intravoxel incoherent motion quantification and the role of the Intervoxel spatial distribution of flow velocities
Precision of <span>region of interest</span>‐based tri‐exponential intravoxel incoherent motion quantification and the role of the Intervoxel spatial distribution of flow velocities Open
Purpose The purpose of this work was to obtain precise tri‐exponential intravoxel incoherent motion (IVIM) quantification in the liver using 2D ( b ‐value and first‐order motion moment [ M 1 ]) IVIM‐DWI acquisitions and region of interest …
View article: <i>b</i> value and first‐order motion moment optimized data acquisition for repeatable quantitative intravoxel incoherent motion DWI
<i>b</i> value and first‐order motion moment optimized data acquisition for repeatable quantitative intravoxel incoherent motion DWI Open
Purpose To design a b value and first‐order motion moment (M 1 ) optimized data acquisition for repeatable intravoxel incoherent motion (IVIM) quantification in the liver. Methods Cramer‐Rao lower bound optimization was performed to determ…
View article: Spectroscopy‐based multi‐parametric quantification in subjects with liver iron overload at 1.5T and 3T
Spectroscopy‐based multi‐parametric quantification in subjects with liver iron overload at 1.5T and 3T Open
Purpose To evaluate the precision profile (repeatability and reproducibility) of quantitative STEAM‐MRS and to determine the relationships between multiple MR biomarkers of chronic liver disease in subjects with iron overload at both 1.5 T…
View article: Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI
Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI Open
Functional magnetic resonance imaging (fMRI) has significant potential to evaluate changes in brain network activity after traumatic brain injury (TBI) and enable early prognosis of potential functional (e.g., motor, cognitive, behavior) d…
View article: Engineered glycomaterial implants orchestrate large-scale functional repair of brain tissue chronically after severe traumatic brain injury
Engineered glycomaterial implants orchestrate large-scale functional repair of brain tissue chronically after severe traumatic brain injury Open
Engineered glycomaterial implants orchestrate large-scale repair after severe traumatic brain injury.
View article: Reactive Oxygen Species-Triggered Dissociation of a Polyrotaxane-Based Nanochelator for Enhanced Clearance of Systemic and Hepatic Iron
Reactive Oxygen Species-Triggered Dissociation of a Polyrotaxane-Based Nanochelator for Enhanced Clearance of Systemic and Hepatic Iron Open
Chronic blood transfusions are used to alleviate anemic symptoms in thalassemia and sickle cell anemia patients but can eventually result in iron overload (IO) and subsequently lead to severe oxidative stress in cells and tissues. Deferoxa…
View article: Neurotrophic Factor-Laden Acellular Chondroitin Sulfate Scaffolds Promote Chronic Functional Recovery After Severe Traumatic Brain Injury
Neurotrophic Factor-Laden Acellular Chondroitin Sulfate Scaffolds Promote Chronic Functional Recovery After Severe Traumatic Brain Injury Open
Severe traumatic brain injury (sTBI) survivors experience permanent functional disabilities due to significant volume loss and the brain’s poor capacity to regenerate. Chondroitin sulfate glycosaminoglycans (CS-GAGs) are key regulators of …
View article: Surfen‐mediated blockade of extratumoral chondroitin sulfate glycosaminoglycans inhibits glioblastoma invasion
Surfen‐mediated blockade of extratumoral chondroitin sulfate glycosaminoglycans inhibits glioblastoma invasion Open
Invasive spread of glioblastoma (GBM) is linked to changes in chondroitin sulfate (CS) proteoglycan (CSPG)‐associated sulfated glycosaminoglycans (GAGs) that are selectively up‐regulated in the tumor microenvironment (TME). We hypothesized…
View article: Pig Brains Have Homologous Resting-State Networks with Human Brains
Pig Brains Have Homologous Resting-State Networks with Human Brains Open
Many neurological and psychiatric diseases in humans are caused by disruptions to large-scale functional properties of the brain, including functional connectivity. There has been growing interest in discovering the functional organization…
View article: Assessment of MR‐based and quantitative susceptibility mapping for the quantification of liver iron concentration in a mouse model at 7T
Assessment of MR‐based and quantitative susceptibility mapping for the quantification of liver iron concentration in a mouse model at 7T Open
Purpose To assess the feasibility of quantifying liver iron concentration (LIC) using and quantitative susceptibility mapping (QSM) at a high field strength of 7 Tesla (T). Methods Five different concentrations of Fe‐dextran were injected …
View article: Zika Virus Induced Mortality and Microcephaly in Chicken Embryos
Zika Virus Induced Mortality and Microcephaly in Chicken Embryos Open
The explosive spread of the Zika virus (ZIKV) through South and Central America has been linked to an increase in congenital birth defects, specifically microcephaly. Representative rodent models for investigating infections include direct…
View article: Tracking and Quantification of Magnetically Labeled Stem Cells Using Magnetic Resonance Imaging
Tracking and Quantification of Magnetically Labeled Stem Cells Using Magnetic Resonance Imaging Open
Stem cell based therapies have critical impacts on treatments and cures of diseases such as neurodegenerative or cardiovascular disease. In vivo tracking of stem cells labeled with magnetic contrast agents is of particular interest and imp…