Thomas G. Knight
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View article: CHARM is Prognostic of Geriatric Morbidity and Toxicity after Allogeneic Transplant for Older Adults: BMT CTN 1704 Study
CHARM is Prognostic of Geriatric Morbidity and Toxicity after Allogeneic Transplant for Older Adults: BMT CTN 1704 Study Open
Despite concerns about the toxicity of allogeneic hematopoietic cell transplantation (alloHCT) in older patients, prospective data are limited characterizing prevalence or risk-stratification for geriatric morbidity such as disability or f…
View article: DISP-02. Financial toxicity: frequency, impact, and unmet needs in primary brain malignancy
DISP-02. Financial toxicity: frequency, impact, and unmet needs in primary brain malignancy Open
Financial toxicity, representing the burden and distress of healthcare costs to patients and families, is high within medical oncology. Oncology nurse navigation (ONN) plays an important role in guiding cancer patients toward resources to …
View article: Interventions for assessment and medical care without hospital transfer for older people living with frailty: findings from a formative evaluation
Interventions for assessment and medical care without hospital transfer for older people living with frailty: findings from a formative evaluation Open
Introduction Medical care in the community as an alternative to hospitalisation is central to the NHS strategy to reduce hospital admissions of older people living with frailty. There is little evidence on how community care is provided an…
View article: The Financial Toxicity Tumor Board: 5-Year Update on Practice and a Guide to Implementation
The Financial Toxicity Tumor Board: 5-Year Update on Practice and a Guide to Implementation Open
Background: Financial toxicity has been increasingly recognized as a major driver of negative outcomes for patients with cancer, with prior interventions focused primarily on patient-level support. The Financial Toxicity Tumor Board (FTTB)…
View article: Provision of medical same day emergency care services within the UK: analysis from the Society for Acute Medicine Benchmarking Audit
Provision of medical same day emergency care services within the UK: analysis from the Society for Acute Medicine Benchmarking Audit Open
Aim To evaluate the current provision of medical same day emergency care (SDEC) services within the UK, and the current utilisation of these pathways in the assessment of unplanned medical attendances. Design Survey data was used from the …
View article: Novel composite health assessment risk model for older allogeneic transplant recipients: BMT-CTN 1704
Novel composite health assessment risk model for older allogeneic transplant recipients: BMT-CTN 1704 Open
Allogeneic hematopoietic cell transplantation (allo-HCT) is potentially curative for older adults with hematologic malignancies. Concerns on nonrelapse mortality (NRM) in older adults limit allo-HCT utilization. We executed a prospective, …
View article: Provision of medical Same Day Emergency Care services within the UK: analysis from the Society for Acute Medicine Benchmarking Audit
Provision of medical Same Day Emergency Care services within the UK: analysis from the Society for Acute Medicine Benchmarking Audit Open
Aim To evaluate current provision of medical Same Day Emergency Care (SDEC) services within the UK, and current utilisation of these pathways in the assessment of unplanned medical attendances. Design Survey data was used from the Society …
View article: Biologically Randomized Comparison of Haploidentical Versus Human Leukocyte Antigen-Matched Related Donor Reduced-Intensity Conditioning Hematopoietic Cell Transplantation
Biologically Randomized Comparison of Haploidentical Versus Human Leukocyte Antigen-Matched Related Donor Reduced-Intensity Conditioning Hematopoietic Cell Transplantation Open
Using haploidentical donors for allogeneic hematopoietic cell transplantation (HCT) broadens transplant accessibility to a growing number of patients with hematologic disorders. Moreover, haploidentical HCT with post-transplant cyclophosph…
View article: Evaluating acute medical service performance against assessment time metrics: the Society for Acute Medicine Benchmarking Audit 2023 (SAMBA23)
Evaluating acute medical service performance against assessment time metrics: the Society for Acute Medicine Benchmarking Audit 2023 (SAMBA23) Open
Performance within acute medicine services is impacted by ongoing pressures on acute care services. Data from the Society for Acute Medicine Benchmarking Audit 2023 (SAMBA23), was used to assess performance of acute medicine services compa…
View article: Hematocrit control and thrombotic risk in patients with polycythemia vera treated with ruxolitinib in clinical practice
Hematocrit control and thrombotic risk in patients with polycythemia vera treated with ruxolitinib in clinical practice Open
Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by unregulated red blood cell production resulting in elevated hemoglobin (HGB) and/or hematocrit (HCT). Patients often have clinical symptoms such as fatigue, pruritus,…
View article: Derived Electron Densities from Linear Polarization Observations of the Visible-Light Corona During the 14 December 2020 Total Solar Eclipse
Derived Electron Densities from Linear Polarization Observations of the Visible-Light Corona During the 14 December 2020 Total Solar Eclipse Open
A new instrument was designed to take visible-light (VL) polarized brightness ( $\mathit{pB}$ ) observations of the solar corona during the 14 December 2020 total solar eclipse. The instrument, called the Coronal Imaging Polarizer (CIP),…
View article: Socioeconomic Disadvantage Is Associated with Decreased Long-Term Survival in Adolescent and Young Adult Patients with Acute Lymphoblastic Leukemia
Socioeconomic Disadvantage Is Associated with Decreased Long-Term Survival in Adolescent and Young Adult Patients with Acute Lymphoblastic Leukemia Open
Background: The treatment of acute lymphoblastic leukemia (ALL) in the adolescent and young adult (AYA) population has dramatically improved over the past decade with the use of pediatric-inspired regimens increasing long-term survival rat…
View article: Derived electron densities from linear polarization observations of the visible-light corona during the 14 December 2020 total solar eclipse
Derived electron densities from linear polarization observations of the visible-light corona during the 14 December 2020 total solar eclipse Open
A new instrument was designed to take visible-light (VL) polarized brightness ($pB$) observations of the solar corona during the 14 December 2020 total solar eclipse. The instrument, called the Coronal Imaging Polarizer (CIP), consisted of…
View article: Performance of admission pathways within acute medicine services: Analysis from the Society for Acute Medicine Benchmarking Audit 2022 and comparison with performance 2019 - 2021
Performance of admission pathways within acute medicine services: Analysis from the Society for Acute Medicine Benchmarking Audit 2022 and comparison with performance 2019 - 2021 Open
Urgent and emergency care services face increasing pressure, impacting patient care. We evaluated the performance of acute medicine services, assessing clinical quality indicators for unplanned medical admissions to acute hospital services…
View article: Guest Editorial – Pulmonary Embolism: the risk of what we don’t yet know!
Guest Editorial – Pulmonary Embolism: the risk of what we don’t yet know! Open
Pulmonary embolism (PE) is a common and potentially life-threatening condition encountered routinely in acute care.1, 2 The diagnosis and management of PE has been the topic of National Institute of Health Care Excellence3 and European Car…
View article: CORONA (COre ultRasOund of covid in iNtensive care and Acute medicine) study: National service evaluation of lung and heart ultrasound in intensive care patients with suspected or proven COVID-19
CORONA (COre ultRasOund of covid in iNtensive care and Acute medicine) study: National service evaluation of lung and heart ultrasound in intensive care patients with suspected or proven COVID-19 Open
Background Combined Lung Ultrasound (LUS) and Focused UltraSound for Intensive Care heart (FUSIC Heart - formerly Focused Intensive Care Echocardiography, FICE) can aid diagnosis, risk stratification and management in COVID-19. However, da…
View article: Platform Incorporating Patient Navigation, Preparative Guidelines, and Hospital at Home May Improve COVID-19 Outcomes for Patients with Myeloid Malignancies
Platform Incorporating Patient Navigation, Preparative Guidelines, and Hospital at Home May Improve COVID-19 Outcomes for Patients with Myeloid Malignancies Open
Background: Patients (pts) with malignancies are at increased risk of morbidity and mortality from COVID-19. Among these pts, some of the higher case fatality ratios (CFR) reported are among pts with myeloid malignancies, ranging from 37 t…