Gregory V. Coe
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View article: Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance
Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance Open
Adolescents with T1D have adipose, hepatic and peripheral IR. This IR occurs regardless of obesity and metabolic syndrome features. Youth with T1D may benefit from interventions directed at improving IR in these tissues, and this area requ…
View article: Insulin Resistance, Hyperinsulinemia, and Mitochondria Dysfunction in Nonobese Girls With Polycystic Ovarian Syndrome
Insulin Resistance, Hyperinsulinemia, and Mitochondria Dysfunction in Nonobese Girls With Polycystic Ovarian Syndrome Open
Normal-weight girls with PCOS have decreased peripheral IS and muscle mitochondrial dysfunction, abnormal glucose disposal, relative postprandial hyperinsulinemia, and increased hepatic fat compared to NWC. Despite a normal BMI, multiple a…
View article: Hepatic Steatosis is Common in Adolescents with Obesity and <scp>PCOS</scp> and Relates to <i>De Novo</i> Lipogenesis but not Insulin Resistance
Hepatic Steatosis is Common in Adolescents with Obesity and <span>PCOS</span> and Relates to <i>De Novo</i> Lipogenesis but not Insulin Resistance Open
Objective Increased liver fat and type 2 diabetes are prevalent in women with polycystic ovarian syndrome (PCOS) and cause excess mortality, yet little is known about their development during adolescence. The objective of this study was to…