Gregory Weitsman
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View article: TLR9 Downregulation in Breast Cancer: Its Role in Tumor Immunity, Inflammatory Response, and Cellular Senescence
TLR9 Downregulation in Breast Cancer: Its Role in Tumor Immunity, Inflammatory Response, and Cellular Senescence Open
Toll-like receptor 9 (TLR9) is primarily expressed in human dendritic and B cells and recognizes double-stranded DNA motifs from pathogens to initiate an inflammatory response. Recent studies have revealed TLR9's involvement beyond its con…
View article: Supplementary Video from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma
Supplementary Video from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma Open
Supplementary video showing fluorescence-guided resection of a subcutaneous model of Neuroblastoma injected with anti-GD2 fluorescence probes
View article: Supplementary Data from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma
Supplementary Data from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma Open
Supplementary methods and figures
View article: Supplementary Data from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma
Supplementary Data from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma Open
Supplementary methods and figures
View article: Supplementary Video from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma
Supplementary Video from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma Open
Supplementary video showing fluorescence-guided resection of a subcutaneous model of Neuroblastoma injected with anti-GD2 fluorescence probes
View article: The MondoA-dependent TXNIP/GDF15 axis predicts oxaliplatin response in colorectal adenocarcinomas
The MondoA-dependent TXNIP/GDF15 axis predicts oxaliplatin response in colorectal adenocarcinomas Open
Chemotherapy, the standard of care treatment for cancer patients with advanced disease, has been increasingly recognized to activate host immune responses to produce durable outcomes. Here, in colorectal adenocarcinoma (CRC) we identify ox…
View article: The Impact of TLR9 Expression Loss on Breast Cancer Tumor Cells
The Impact of TLR9 Expression Loss on Breast Cancer Tumor Cells Open
Toll-like receptor 9 (TLR9), primarily expressed in human dendritic and B cells, recognizes double-stranded DNA motifs from pathogens, initiating an inflammatory response. Recent studies have revealed TLR9’s involvement beyond its conventi…
View article: Figure 1 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 1 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Multispectral NIR-I/SWIR fluorescence imaging device. Photograph of the custom multispectral NIR-I/SWIR fluorescence imaging system alongside its schematic representation. The spectral characteristics of the device are shown including the …
View article: Figure 2 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 2 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Overview of the in vivo preclinical study. A, Six to 8-week-old athymic nude female mice LAN-1 xenografts were injected with either anti–GD2-IR800 or anti–GD-IR12. The control mice were not injected. Mice were imaged at 24, 48, 72, and 96 …
View article: Supplementary Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Supplementary Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Supplementary methods and figures
View article: Figure 6 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 6 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Imaging of stained cell pellets beneath tissue-mimicking material using multispectral NIR-I/SWIR fluorescence imaging. A, Microcentrifuges tubes containing pellets of 2 × 106 GD2-positive cells (LAN-1) and GD2-negative cells (SUPT1-WT) sta…
View article: Supplementary Video from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Supplementary Video from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Supplementary video showing fluorescence-guided resection of a subcutaneous model of Neuroblastoma injected with anti-GD2 fluorescence probes
View article: Supplementary Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Supplementary Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Supplementary methods and figures
View article: Supplementary Video from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Supplementary Video from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Supplementary video showing fluorescence-guided resection of a subcutaneous model of Neuroblastoma injected with anti-GD2 fluorescence probes
View article: Figure 2 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 2 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Overview of the in vivo preclinical study. A, Six to 8-week-old athymic nude female mice LAN-1 xenografts were injected with either anti–GD2-IR800 or anti–GD-IR12. The control mice were not injected. Mice were imaged at 24, 48, 72, and 96 …
View article: Figure 1 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 1 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Multispectral NIR-I/SWIR fluorescence imaging device. Photograph of the custom multispectral NIR-I/SWIR fluorescence imaging system alongside its schematic representation. The spectral characteristics of the device are shown including the …
View article: Figure 3 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 3 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
In vitro validation of anti–GD2-IR800 and anti–GD2-IR12. A, Binding specificity of anti–GD2-IR800 and anti–GD2-IR12 conjugates assessed by flow cytometry in three GD2-positive cell lines (KELLY, LAN-1, and SUPT1-GD2) and in the negative co…
View article: Figure 3 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 3 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
In vitro validation of anti–GD2-IR800 and anti–GD2-IR12. A, Binding specificity of anti–GD2-IR800 and anti–GD2-IR12 conjugates assessed by flow cytometry in three GD2-positive cell lines (KELLY, LAN-1, and SUPT1-GD2) and in the negative co…
View article: Figure 7 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 7 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Biological evaluation of anti–GD2-IR800 and anti–GD2-IR12 using a preclinical NIR-I imaging system in vivo. A, IVIS Spectrum images of the exposed tumors at 24, 48, 72, and 96 hours postinjection of anti–GD2-IR800 (n = 3) and anti–GD2-IR12…
View article: Figure 5 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 5 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
In vitro multispectral NIR-I/SWIR fluorescence imaging of anti–GD2-IR800 and anti–GD2-IR12 A. Schematic representation of selected cell lines (left) and number of cells used (right) to assess the camera sensitivity. Cells were stained with…
View article: Figure 8 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 8 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
SWIR imaging achieves a higher TBR than NIR-I imaging. A, Normalized band images of exposed tumors at 24 hours post conjugates injection. Images show increased TBR at longer wavelengths. B, Normalized band images (900 and 1,300 nm only) 48…
View article: Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Fluorescence-guided surgery is set to play a pivotal role in the intraoperative management of pediatric tumors. Shortwave infrared imaging (SWIR) has advantages over conventional near-infrared I (NIR-I) imaging with reduced tissue scatteri…
View article: Figure 7 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 7 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Biological evaluation of anti–GD2-IR800 and anti–GD2-IR12 using a preclinical NIR-I imaging system in vivo. A, IVIS Spectrum images of the exposed tumors at 24, 48, 72, and 96 hours postinjection of anti–GD2-IR800 (n = 3) and anti–GD2-IR12…
View article: Figure 6 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 6 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Imaging of stained cell pellets beneath tissue-mimicking material using multispectral NIR-I/SWIR fluorescence imaging. A, Microcentrifuges tubes containing pellets of 2 × 106 GD2-positive cells (LAN-1) and GD2-negative cells (SUPT1-WT) sta…
View article: Figure 8 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 8 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
SWIR imaging achieves a higher TBR than NIR-I imaging. A, Normalized band images of exposed tumors at 24 hours post conjugates injection. Images show increased TBR at longer wavelengths. B, Normalized band images (900 and 1,300 nm only) 48…
View article: Figure 4 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 4 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
In vivo validation of tumor uptake of anti–GD2-IR800 and anti–GD2-IR12 using a commercially available clinical NIR-I imaging device. A, Comparison of fluorescent images of the unexposed tumors at different time points postinjection of eith…
View article: Figure 5 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 5 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
In vitro multispectral NIR-I/SWIR fluorescence imaging of anti–GD2-IR800 and anti–GD2-IR12 A. Schematic representation of selected cell lines (left) and number of cells used (right) to assess the camera sensitivity. Cells were stained with…
View article: Figure 4 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Figure 4 from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
In vivo validation of tumor uptake of anti–GD2-IR800 and anti–GD2-IR12 using a commercially available clinical NIR-I imaging device. A, Comparison of fluorescent images of the unexposed tumors at different time points postinjection of eith…
View article: Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Fluorescence-guided surgery is set to play a pivotal role in the intraoperative management of pediatric tumors. Shortwave infrared imaging (SWIR) has advantages over conventional near-infrared I (NIR-I) imaging with reduced tissue scatteri…
View article: Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Data from Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma Open
Fluorescence-guided surgery is set to play a pivotal role in the intraoperative management of pediatric tumors. Shortwave infrared imaging (SWIR) has advantages over conventional near-infrared I (NIR-I) imaging with reduced tissue scatteri…