ABSTRACT Cisplatin, that is, cis-diamminedichloroplatinum is a coordinate compound that is mainly preferred as prior treatment against several solid tumors and malignancies like ovaries, head and neck, testicular, and lung cancers because of its anticancer activity. Cisplatin binds at the N7 position of purine and forms adducts, leading to altered activity of DNA that triggers apoptosis. DNA damage is followed by several signaling pathways like induced oxidative stress, upregulated p53, mitogen-activated protein k…

ABSTRACT Introduction: Ovarian and breast cancers are highly prevalent in the population of Jammu and Kashmir (J&K). However, case–control association studies on breast and ovarian cancers are lacking in this population. Moreover, no case–control study is available on variant rs10937405 of TP63 in breast and ovarian cancers. Thus, we designed to replicate the cancer susceptible variant rs10937405 of TP63 in ovarian and breast cancers in the population of J&K because the TP63 gene act as a tumor suppressor …

Polycystic ovary syndrome (PCOS) can be mainly defined as a gynecological problem accompanied by an endocrine disturbance in females and can be seen mainly during their menstruation age. Worldwide PCOS prevalence ranges between 6% and 10%. Many of the risk factors are responsible for the pathogenesis of PCOS. Environmental factors such as environmental toxins and obesity play a major role in the occurrence of PCOS, followed by the hormonal disturbance in androgen levels, that is, hyperandrogenism, and insulin leve…

Ovarian cancer is not a single disorder having different histological types which are associated with germline or somatic mutations. Histological types include epithelial cancers that account for ~90% of ovarian cancers and include serous, endometrioid, clear-cell and mucinous carcinomas. There are several risk factors for developing ovarian cancer which includes a genetic factor, age, use of hormonal therapy after menopause, null parity, infertility and other factors including obesity, lifestyle, dietary habits. …

Infertility is an inability to get pregnant after 1 year of trying. Infertility is a serious condition which not only affects the physical health of a woman but also influences a woman psychologically. Infertility in females is growing rapidly throughout the world. It is the fifth most serious disability in the world. The woman’s inability to get pregnant leads to many psychological problems such as sadness, anger, depression, anxiety, loss of social status, lack of self-esteem, and poor quality of life. There is …