Greta Maria Paola Giordano Attianese
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View article: Highly efficient gene knockout in tumor-infiltrating lymphocytes by adenine base editing
Highly efficient gene knockout in tumor-infiltrating lymphocytes by adenine base editing Open
The disruption of immune checkpoints in T cells is a promising tool for improving the efficacy of tumor-infiltrating lymphocyte (TIL) therapy. While CRISPR-Cas9 genome-editing is efficient, Cas9 nucleases induce double-strand DNA breaks an…
View article: DNA-dependent protein kinase inhibitors PI-103 and samotolisib augment CRISPR/Cas9 knock-in efficiency in human T cells
DNA-dependent protein kinase inhibitors PI-103 and samotolisib augment CRISPR/Cas9 knock-in efficiency in human T cells Open
The adoptive transfer of autologous peripheral blood T cells gene-modified to express preselected, tumor antigen-specific T-cell receptors (TCRs) is a promising treatment for solid cancers. While gene-transfer by viral transduction is high…
View article: Dual ON/OFF-switch chimeric antigen receptor controlled by two clinically approved drugs
Dual ON/OFF-switch chimeric antigen receptor controlled by two clinically approved drugs Open
The ability to remotely control the activity of chimeric antigen receptors (CARs) with small molecules can improve the safety and efficacy of gene-modified T cells. Split ON- or OFF-switch CARs involve the dissociation of tumor–antigen bin…
View article: Drug-controlled CAR-T cells through the regulation of cell-cell interactions
Drug-controlled CAR-T cells through the regulation of cell-cell interactions Open
CAR T-cell therapy is constrained by on-target, off-tumor toxicities as well as cellular exhaustion due to chronic antigen exposure. CARs comprising small-molecule controlled switches can enhance both safety and therapeutic efficacy but ar…
View article: Coengineering specificity, safety, and function into T cells for cancer immunotherapy
Coengineering specificity, safety, and function into T cells for cancer immunotherapy Open
Summary Adoptive T‐cell transfer (ACT) therapies, including of tumor infiltrating lymphocytes (TILs) and T cells gene‐modified to express either a T cell receptor (TCR) or a chimeric antigen receptor (CAR), have demonstrated clinical effic…
View article: A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor
A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor Open
Vectors that facilitate the engineering of T cells that can better harness endogenous immunity and overcome suppressive barriers in the tumour microenvironment would help improve the safety and efficacy of T-cell therapies for more patient…
View article: A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism
A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism Open
View article: Enforcing GLUT3 expression in CD8+ T cells improves fitness and tumor control by promoting glucose uptake and energy storage
Enforcing GLUT3 expression in CD8+ T cells improves fitness and tumor control by promoting glucose uptake and energy storage Open
Despite the tremendous success of adoptive T-cell therapies (ACT) in fighting certain hematologic malignancies, not all patients respond, a proportion experience relapse, and effective ACT of most solid tumors remains elusive. In order to …
View article: CAR T cells targeting the ganglioside NGcGM3 control ovarian tumors in the absence of toxicity against healthy tissues
CAR T cells targeting the ganglioside NGcGM3 control ovarian tumors in the absence of toxicity against healthy tissues Open
Chimeric antigen receptor (CAR) T cells have emerged as a powerful immunotherapeutic tool against certain hematological malignancies but a significant proportion of patients either do not respond or they relapse, sometimes as a result of t…
View article: Lenalidomide enhances CD23.CAR T cell therapy in chronic lymphocytic leukemia
Lenalidomide enhances CD23.CAR T cell therapy in chronic lymphocytic leukemia Open
Chimeric antigen receptors (CAR)-modified T cells are an emerging therapeutic tool for chronic lymphocytic leukemia (CLL). However, in patients with CLL, well-known T-cell defects and the inhibitory properties of the tumor microenvironment…
View article: Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
Magnesium sensing via LFA-1 regulates CD8+ T cell effector function Open
View article: Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue
Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue Open
View article: Hemicentin 1 influences podocyte dynamic changes in glomerular diseases
Hemicentin 1 influences podocyte dynamic changes in glomerular diseases Open
Different complex mechanisms control the morphology of podocyte foot processes and their interactions with the underlying basement membrane. Injuries to this system often cause glomerular dysfunction and albuminuria. The present study aime…
View article: Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion
Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion Open
View article: Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved <i>Sleeping Beauty</i> transposon platform
Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved <i>Sleeping Beauty</i> transposon platform Open
Chimeric antigen receptor (CAR)-modified T-cell adoptive immunotherapy is a remarkable therapeutic option proven effective in the treatment of hematological malignancies. In order to optimize cell manufacturing, we sought to develop a nove…