Gretchen Seim
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View article: Systemic cytokines drive conserved severity-associated myeloid responses across bacterial and viral infections
Systemic cytokines drive conserved severity-associated myeloid responses across bacterial and viral infections Open
Both bacterial and viral infections can trigger an overwhelming host response, leading to immunopathology and organ dysfunction. Multiple studies have reported dysregulated myeloid cell states in patients with bacterial sepsis or severe SA…
View article: Macrophages undergo functionally significant reprograming of nucleotide metabolism upon classical activation
Macrophages undergo functionally significant reprograming of nucleotide metabolism upon classical activation Open
During an immune response, macrophages systematically rewire their metabolism in specific ways to support their diversve functions. However, current knowledge of macrophage metabolism is largely concentrated on central carbon metabolism. U…
View article: Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism
Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism Open
Branched chain α-ketoacid dehydrogenase complex (BCKDC) is the rate-limiting enzyme in branched chain amino acid (BCAA) catabolism, a metabolic pathway with great importance for human health. BCKDC belongs to the mitochondrial α-ketoacid d…
View article: Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism
Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism Open
Branched chain α-ketoacid dehydrogenase complex (BCKDC) is the rate limiting enzyme in branched chain amino acid (BCAA) catabolism, a metabolic pathway with great importance for human health. BCKDC belongs to the mitochondrial α-ketoacid d…
View article: Asparagine starvation suppresses histone demethylation through iron depletion
Asparagine starvation suppresses histone demethylation through iron depletion Open
Intracellular α-ketoglutarate is an indispensable substrate for the Jumonji family of histone demethylases (JHDMs) mediating most of the histone demethylation reactions. Since α-ketoglutarate is an intermediate of the tricarboxylic acid cy…
View article: Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases
Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases Open
View article: Asparagine bioavailability regulates the translation of MYC oncogene
Asparagine bioavailability regulates the translation of MYC oncogene Open
View article: Asparagine starvation suppresses histone demethylation through iron depletion
Asparagine starvation suppresses histone demethylation through iron depletion Open
Nutrient availability can impact epigenome to modify gene expression and dictate cell fate decision (Etchegaray and Mostoslavsky, 2016; Kinnaird et al., 2016). α-ketoglutarate is an indispensable substrate for the Jumonji family of histone…
View article: Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils
Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils Open
Neutrophils are cells at the frontline of innate immunity that can quickly activate effector functions to eliminate pathogens upon stimulation. However, little is known about the metabolic adaptations that power these functions. Here we sh…
View article: A matter of time: temporal structure and functional relevance of macrophage metabolic rewiring
A matter of time: temporal structure and functional relevance of macrophage metabolic rewiring Open
View article: Modifications of lipoic arm by reactive nitrogen species regulate α-ketoacid dehydrogenases
Modifications of lipoic arm by reactive nitrogen species regulate α-ketoacid dehydrogenases Open
Mitochondrial α-ketoacid dehydrogenases, including the pyruvate dehydrogenase complex (PDHC) and the oxoglutarate dehydrogenase complex (OGDC), are a family of multi-subunit enzyme complexes that use a lipoic arm to transfer an acyl group …
View article: Discovering How Heme Controls Genome Function Through Heme-omics
Discovering How Heme Controls Genome Function Through Heme-omics Open
View article: Metabolomic and Lipidomic Analysis of Bone Marrow Derived Macrophages
Metabolomic and Lipidomic Analysis of Bone Marrow Derived Macrophages Open
Macrophages are highly plastic immune cells that are capable of adopting a wide array of functional phenotypes in response to environmental stimuli. The changes in macrophage function are often supported and regulated by changes in cellula…
View article: Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion
Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion Open
View article: Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation
Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation Open
View article: A Novel in Vivo Model for Assessing the Impact of Geophagic Earth on Iron Status
A Novel in Vivo Model for Assessing the Impact of Geophagic Earth on Iron Status Open
The causes and consequences of geophagy, the craving and consumption of earth, remain enigmatic, despite its recognition as a behavior with public health implications. Iron deficiency has been proposed as both a cause and consequence of ge…
View article: Translating formative research findings into a behaviour change strategy to promote antenatal calcium and iron and folic acid supplementation in western Kenya
Translating formative research findings into a behaviour change strategy to promote antenatal calcium and iron and folic acid supplementation in western Kenya Open
The World Health Organization now recommends integrating calcium supplements into antenatal micronutrient supplementation programmes to prevent pre‐eclampsia, a leading cause of maternal mortality. As countries consider integrating calcium…