Victoria V. Grishko
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View article: Ингибирующие и вирулицидные свойства полусинтетических производных бетулина в отношении вируса герпеса простого
Ингибирующие и вирулицидные свойства полусинтетических производных бетулина в отношении вируса герпеса простого Open
Исследованы вирусингибирующие и вирулицидные свойства полусинтетических тритерпеноидов в отношении вируса герпеса 1 типа. Действие наиболее перспективных соединений, активных также в отношении ацикловир-устойчивого штамма вируса герпеса 2 …
View article: Synthesis and Intramolecular Regioselective Cyclization of 2-Cyano-3,10-dioxo-1,10-seco-1,25-dinorlupan-28-yl Benzoate
Synthesis and Intramolecular Regioselective Cyclization of 2-Cyano-3,10-dioxo-1,10-seco-1,25-dinorlupan-28-yl Benzoate Open
The paper describes the synthesis of a new 1,10-seco-triterpenoid with a 2-cyano-3,10-diketone fragment and its further regioselective cyclization under acidic and basic conditions with the formation of 2S-cyanopyran-3-one derivative or A-…
View article: Synthesis of furanotriterpenoids from betulin and evaluation of Tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibitory properties of new semi-synthetic triterpenoids
Synthesis of furanotriterpenoids from betulin and evaluation of Tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibitory properties of new semi-synthetic triterpenoids Open
View article: Search for new bioactive compounds based on microbial transformation of oleanane type pentacyclic triterpenoids
Search for new bioactive compounds based on microbial transformation of oleanane type pentacyclic triterpenoids Open
Against the backdrop of a lack of highly effective pharmacological agents for the treatment of socially significant diseases, the search for new chemical compounds with biological activity based on plant pentacyclic triterpenoids, includin…
View article: CCDC 2211937: Experimental Crystal Structure Determination
CCDC 2211937: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2190242: Experimental Crystal Structure Determination
CCDC 2190242: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents
Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents Open
Terpenes and their derivatives (terpenoids and meroterpenoids, in particular) constitute the largest class of natural compounds, which have valuable biological activities and are promising therapeutic agents. The present review assesses th…
View article: Synthesis and Anticancer Activity of A-Ring-Modified Derivatives of Dihydrobetulin
Synthesis and Anticancer Activity of A-Ring-Modified Derivatives of Dihydrobetulin Open
Multidrug resistance (MDR) is a common phenomenon in clinical oncology, whereby cancer cells become resistant to chemotherapeutic drugs. A common MDR mechanism is the overexpression of ATP-binding cassette efflux transporters in cancer cel…
View article: CCDC 2174771: Experimental Crystal Structure Determination
CCDC 2174771: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2194080: Experimental Crystal Structure Determination
CCDC 2194080: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Rhodococcus rhodochrous IEGM 1360, an Effective Biocatalyst of C3 Oxidative Transformation of Oleanane Triterpenoids
Rhodococcus rhodochrous IEGM 1360, an Effective Biocatalyst of C3 Oxidative Transformation of Oleanane Triterpenoids Open
The online version contains supplementary material available at 10.1134/S0026261722603360.
View article: The Molecular Mechanisms of Oleanane Aldehyde-β-enone Cytotoxicity against Doxorubicin-Resistant Cancer Cells
The Molecular Mechanisms of Oleanane Aldehyde-β-enone Cytotoxicity against Doxorubicin-Resistant Cancer Cells Open
Oleanane aldehyde-β-enone (OA), being the semi-synthetic derivative of the triterpenoid betulin, effectively inhibits the proliferation of HBL-100 and K562 cancer cells (IC50 0.47–0.53 µM), as well as the proliferation of their resistant s…
View article: CCDC 2167086: Experimental Crystal Structure Determination
CCDC 2167086: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2167088: Experimental Crystal Structure Determination
CCDC 2167088: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2167090: Experimental Crystal Structure Determination
CCDC 2167090: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2167084: Experimental Crystal Structure Determination
CCDC 2167084: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2169665: Experimental Crystal Structure Determination
CCDC 2169665: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2167087: Experimental Crystal Structure Determination
CCDC 2167087: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2167089: Experimental Crystal Structure Determination
CCDC 2167089: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2167085: Experimental Crystal Structure Determination
CCDC 2167085: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2167092: Experimental Crystal Structure Determination
CCDC 2167092: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2167091: Experimental Crystal Structure Determination
CCDC 2167091: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Stereoselective Epoxidation of Triterpenic Allylic Alcohols and Cytotoxicity Evaluation of Synthesized Compounds
Stereoselective Epoxidation of Triterpenic Allylic Alcohols and Cytotoxicity Evaluation of Synthesized Compounds Open
The epoxidation process of semi-synthetic triterpenoids 2-methyl-3-oxo-19β,28-epoxy- 18α-olean-1-ene, and its allylic alcohol derivatives were examined. 1,2α-epoxide, as the main product, was found to be formed from the starting enone expo…
View article: Biotransformation of Oleanolic Acid Using Rhodococcus rhodochrous IEGM 757
Biotransformation of Oleanolic Acid Using Rhodococcus rhodochrous IEGM 757 Open
Using the bioresources of the Regional Specialised Collection of Alkanotrophic Microorganisms (acronym IEGM, Perm, Russia; WFCC # 285), R. rhodochrous IEGM 757 was selected, which catalyzed the C5, C22, and C23 functionalization of pentacy…
View article: Features of the Bioconversion of Pentacyclic Triterpenoid Oleanolic Acid Using Rhodococcus Actinobacteria
Features of the Bioconversion of Pentacyclic Triterpenoid Oleanolic Acid Using Rhodococcus Actinobacteria Open
The ability of actinobacteria of the genus Rhodococcus to transform oleanolic acid (OA), a plant pentacyclic triterpenoid, was shown for the first time using bioresources of the Regional Specialized Collection of AlkanotrophicMicroorganism…
View article: Analysis of morphometric and fractal properties of phase-contrast images of native and apoptotically changed MCF-7 cells
Analysis of morphometric and fractal properties of phase-contrast images of native and apoptotically changed MCF-7 cells Open
This work was aimed at the determination of the morphometric and fractal characteristics of native and apoptotic MCF-7 cells on the basis of the analysis of phase contrast images obtained using laser interference microscopy. MCF-7 cells we…
View article: Label-Free Single Cell Viability Assay Using Laser Interference Microscopy
Label-Free Single Cell Viability Assay Using Laser Interference Microscopy Open
Laser interference microscopy (LIM) is a promising label-free method for single-cell research applicable to cell viability assessment in the studies of mammalian cells. This paper describes the development of a sensitive and reproducible m…
View article: CCDC 1996237: Experimental Crystal Structure Determination
CCDC 1996237: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: ACTINOBACTERIAL TRANSFORMATION OF OLEANANE TRITERPENOIDS
ACTINOBACTERIAL TRANSFORMATION OF OLEANANE TRITERPENOIDS Open
Key words: actinobacteria, Rhodococcus rhodochrous, biologically active compounds, triterpenoids, glycyrrhetinic acid, oleanolic acid Drugs derived from secondary plant metabolites make up about 25% of the global pharmaceutical market [1].…
View article: Analysis of the relief of MCF-7 tumor cells during apoptisis on the basis of phase-contrast images obtained by laser interference microscopy
Analysis of the relief of MCF-7 tumor cells during apoptisis on the basis of phase-contrast images obtained by laser interference microscopy Open
Data on the surface topography of the cell makes it possible to predict its behavior and is an indicator to assess whether it is in a state of apoptosis, that is, in a state of death due to the activation of intracellular reactions; this s…