Yu‐Cheng Gu
YOU?
Author Swipe
View article: Asymmetric vicinal C(sp <sup>3</sup> )–H difunctionalization of saturated cyclic amines <i>via</i> synergistic photoredox, copper and chiral phosphoric acid catalysis
Asymmetric vicinal C(sp <sup>3</sup> )–H difunctionalization of saturated cyclic amines <i>via</i> synergistic photoredox, copper and chiral phosphoric acid catalysis Open
This work reports a synergistic catalysis that integrates photoredox, copper, and CPA. This catalytic system enables the asymmetric synthesis of ring-fused amine skeletons from simple saturated cyclic amines via vicinal C–H bond activation.
View article: TREML2 Modulates Microglial Phagocytosis of Myelin Debris via TLR9 in Chronic Cerebral Ischemia
TREML2 Modulates Microglial Phagocytosis of Myelin Debris via TLR9 in Chronic Cerebral Ischemia Open
Demyelination is a significant pathological feature of chronic cerebral ischemia. Recent evidence suggested that microglia played a protective role in mitigating brain ischemic injury via phagocytosis of myelin debris resulting from demyel…
View article: Hydroxyl Radicals Unlock Strong C( <i>sp</i> <i> <sup>3</sup> </i> )─Si Bonds: Photocatalytic Alkylation and Silacycle Engineering
Hydroxyl Radicals Unlock Strong C( <i>sp</i> <i> <sup>3</sup> </i> )─Si Bonds: Photocatalytic Alkylation and Silacycle Engineering Open
Organosilicon reagents play a significant role in the preparation of molecules essential to synthetic chemistry, materials science, and medicinal chemistry. However, selectively transforming strong C( sp 3 )─Si bonds in unactivated organos…
View article: Macrocyclic geminal diols: synthesis, structures, stability and photophysical properties
Macrocyclic geminal diols: synthesis, structures, stability and photophysical properties Open
New rigid, stable, crystalline macrocyclic gem -diols were synthesized, and their stability was found to depend on ring size: the gem -diol form is favored in smaller rings, whereas the diketone form is more stable in larger ones.
View article: Sesquiterpenoids and Polyacetylenes From <i>Notopterygium Incisum</i> With Anti–Rheumatoid Arthritis Activity
Sesquiterpenoids and Polyacetylenes From <i>Notopterygium Incisum</i> With Anti–Rheumatoid Arthritis Activity Open
Introduction Notopterygium incisum is a traditional Chinese and Tibetan medicinal herb widely used for treating colds, rheumatism, and musculoskeletal disorders. Objectives The aims of the study were to isolate sesquiterpenoids and polyace…
View article: Discovery of Unprecedented Arylation Coupling Cyclopeptide Inspires Natural Product-like Antitubercular Lead Compounds
Discovery of Unprecedented Arylation Coupling Cyclopeptide Inspires Natural Product-like Antitubercular Lead Compounds Open
Tuberculosis (TB) remains one of the world's deadliest communicable diseases. Naturally derived antibiotics appear frequently in nature as collections of structurally similar compounds representing an adaptive evolutionary response to drug…
View article: Real-space study of monolayer hBN encapsulated bilayer MoTe2 devices
Real-space study of monolayer hBN encapsulated bilayer MoTe2 devices Open
Molybdenum ditelluride (MoTe 2 ) has recently emerged as a quantum material platform, especially exhibiting the fractional quantum anomalous Hall (FQAH) effect and unconventional superconductivity in its twisted bilayer configuration. Howe…
View article: The Illusion of Readiness in Health AI
The Illusion of Readiness in Health AI Open
Large language models have demonstrated remarkable performance in a wide range of medical benchmarks. Yet underneath the seemingly promising results lie salient growth areas, especially in cutting-edge frontiers such as multimodal reasonin…
View article: AI-driven advances in the design of RTP and TADF luminescent material
AI-driven advances in the design of RTP and TADF luminescent material Open
The design of room-temperature phosphorescence (RTP) and thermally activated delayed fluorescence (TADF) materials is crucial for advancing organic light-emitting diodes (OLEDs) and other optoelectronic devices. However, traditional experi…
View article: The quality and reliability of short videos about hypertension on TikTok: a cross-sectional study
The quality and reliability of short videos about hypertension on TikTok: a cross-sectional study Open
Hypertension is a major global health risk, and social media platforms like TikTok play an increasing role in public health communication. This study evaluates the quality of hypertension-related videos on TikTok and examines the relations…
View article: Trash or treasure? Unlocking dark matter of enantiomeric natural products in innovative drugs discovery for potent angiogenesis inhibitors
Trash or treasure? Unlocking dark matter of enantiomeric natural products in innovative drugs discovery for potent angiogenesis inhibitors Open
The occurrence and development of tumors rely on the nutritional supply from blood vessels, which also serve as the main pathway for tumor metastasis. Inhibiting angiogenesis is one of the main strategies for cancer treatments. Chiral drug…
View article: Knowledge, attitude, and practice towards primary aldosteronism among healthcare workers in Shanxi province: a multi-center cross-sectional study
Knowledge, attitude, and practice towards primary aldosteronism among healthcare workers in Shanxi province: a multi-center cross-sectional study Open
Primary aldosteronism (PA), though affecting approximately 10% of hypertensive patients, remains significantly underdiagnosed globally, especially in resource-limited healthcare settings. Despite its clinical importance, there is a notable…
View article: Selenium‐Doped Biomass‐Based Nanoparticles Drive Agricultural Emulsions toward a Novel “Offense‐Defense Integration” Strategy
Selenium‐Doped Biomass‐Based Nanoparticles Drive Agricultural Emulsions toward a Novel “Offense‐Defense Integration” Strategy Open
Pesticide formulations with enhanced efficiency and environmental sustainability are crucial for modern agriculture. An agricultural Pickering emulsion (Pro‐Pickering), stabilized by selenium (Se)‐doped zein nanoparticles, developed for de…
View article: The Final Steps in Pseudoiodinine Biosynthesis Feature Ring-Contractive N–N Bond Formation
The Final Steps in Pseudoiodinine Biosynthesis Feature Ring-Contractive N–N Bond Formation Open
Pseudoiodinine (PSD) is a N-N bond-containing natural product with profound antimicrobial and antifungal activities. In this work, we have completed the PSD biosynthetic pathway by explicating the final three steps, which involve an enigma…
View article: Germination fitness differs between penoxsulam resistant and susceptible Echinochloa phyllopogon biotypes
Germination fitness differs between penoxsulam resistant and susceptible Echinochloa phyllopogon biotypes Open
Echinochloa phyllopogon, a malignant weed that mostly reproduces through self-pollination in the paddy fields of Northeast China, currently presents critical resistance concerns. Multiple herbicide-resistant individuals were identified wit…
View article: Base-free oxidation of glycerol to glyceric acid over Pt/biochar catalyst
Base-free oxidation of glycerol to glyceric acid over Pt/biochar catalyst Open
Upgrading the surplus glycerol to access valuable oxygenated-derivatives is of vital importance but confronting the huge challenge of seesaw problem between productivity and selectivity especially in base-free system. We here prepare a ser…
View article: Advances and Challenges in Foundation Agents: From Brain-Inspired Intelligence to Evolutionary, Collaborative, and Safe Systems
Advances and Challenges in Foundation Agents: From Brain-Inspired Intelligence to Evolutionary, Collaborative, and Safe Systems Open
The advent of large language models (LLMs) has catalyzed a transformative shift in artificial intelligence, paving the way for advanced intelligent agents capable of sophisticated reasoning, robust perception, and versatile action across d…
View article: Direct Cyclization of 1,3‐Diketones with Malonate‐Based Iodonium Ylides to Generate Dihydrofurans
Direct Cyclization of 1,3‐Diketones with Malonate‐Based Iodonium Ylides to Generate Dihydrofurans Open
While iodonium ylides are important reactants in a wide range of reactions, the exploration of electron‐transfer property of iodonium ylides remains an underdeveloped topic. Herein, we describe a direct cyclization of 1,3‐diketones with ma…
View article: RankCoT: Refining Knowledge for Retrieval-Augmented Generation through Ranking Chain-of-Thoughts
RankCoT: Refining Knowledge for Retrieval-Augmented Generation through Ranking Chain-of-Thoughts Open
Retrieval-Augmented Generation (RAG) enhances the performance of Large Language Models (LLMs) by incorporating external knowledge. However, LLMs still encounter challenges in effectively utilizing the knowledge from retrieved documents, of…
View article: Learning Refined Document Representations for Dense Retrieval via Deliberate Thinking
Learning Refined Document Representations for Dense Retrieval via Deliberate Thinking Open
Recent dense retrievers increasingly leverage the robust text understanding capabilities of Large Language Models (LLMs), encoding queries and documents into a shared embedding space for effective retrieval. However, most existing methods …
View article: The Endothelial Cell-Related Genes EIF1 and HSPA1B Contribute to the Pathogenesis of Alzheimer’s Disease by Modulating Peripheral Immunoinflammatory Responses
The Endothelial Cell-Related Genes EIF1 and HSPA1B Contribute to the Pathogenesis of Alzheimer’s Disease by Modulating Peripheral Immunoinflammatory Responses Open
Background: Emerging evidence suggests that peripheral immunoinflammatory responses contribute to Alzheimer’s disease (AD) pathogenesis, and endothelial cells (ECs) are involved in these responses. Nevertheless, the potential molecular mec…
View article: Barton–Kellogg Olefination of (CF<sub>3</sub>S)<sub>2</sub>C═S and Subsequent Cyclopropanation for the Installation of Bulky Bis(trifluoromethylthio)methylene Group
Barton–Kellogg Olefination of (CF<sub>3</sub>S)<sub>2</sub>C═S and Subsequent Cyclopropanation for the Installation of Bulky Bis(trifluoromethylthio)methylene Group Open
A protocol was developed for the large-scale preparation (nearly 200 g per batch) of (CF3S)2C=S. The synthesis of gem-bis(trifluoromethylthio)alkenes was achieved through the Barton-Kellogg reaction, without the involvement of trivalent ph…
View article: Universal Abstraction: Harnessing Frontier Models to Structure Real-World Data at Scale
Universal Abstraction: Harnessing Frontier Models to Structure Real-World Data at Scale Open
The vast majority of real-world patient information resides in unstructured clinical text, and the process of medical abstraction seeks to extract and normalize structured information from this unstructured input. However, traditional medi…
View article: Enantioselective reductive cross-couplings to forge C(sp2)–C(sp3) bonds by merging electrochemistry with nickel catalysis
Enantioselective reductive cross-couplings to forge C(sp2)–C(sp3) bonds by merging electrochemistry with nickel catalysis Open
Motivated by the inherent benefits of synergistically combining electrochemical methodologies with nickel catalysis, we present here a Ni-catalyzed enantioselective electroreductive cross-coupling of benzyl chlorides with aryl halides, yie…
View article: Research on Multi-Time Scale Flexible Resource Aggregation and Evaluation for New Power Systems
Research on Multi-Time Scale Flexible Resource Aggregation and Evaluation for New Power Systems Open
The strong uncertainty of the high proportion of new energy and the gradual decrease in the proportion of thermoelectric units have led to a shortage of system flexibility resources. System-level energy storage can efficiently alleviate th…