Guadalupe Gómez Melis
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View article: A journey into biostatistics: Carmen Cadarso’s vision and her commitment to science and society
A journey into biostatistics: Carmen Cadarso’s vision and her commitment to science and society Open
This article celebrates the life and scientific legacy of Carmen Cadarso, a leading figure in the development of Biostatistics in Spain. Combining personal reflections with an overview of her research, we begin by revisiting Carmen's acade…
View article: Correction: Clinical characteristics and predictors of complications and mortality in hospitalized octogenarian patients with COVID-19: an ambispective study
Correction: Clinical characteristics and predictors of complications and mortality in hospitalized octogenarian patients with COVID-19: an ambispective study Open
View article: Impact of washout duration to account for left truncation in register-based epidemiological studies: a case study on estimating the risk of mental disorders
Impact of washout duration to account for left truncation in register-based epidemiological studies: a case study on estimating the risk of mental disorders Open
Background Washout periods can identify and exclude prevalent cases from analyses based on administrative registers with left truncation, but the impact of washout duration on estimates is unknown. We estimated risks of clinically-diagnose…
View article: Discussion on: ‘Simple or complex statistical models: Non-traditional regression models with intuitive interpretations’ by Gillian Z. Heller
Discussion on: ‘Simple or complex statistical models: Non-traditional regression models with intuitive interpretations’ by Gillian Z. Heller Open
1 Comment by Jan Beyersmann My comment focuses on the time-to-event part of Professor Heller's paper but will also lean on the binary outcome part for discussion of the proposed concept of 'simplicity'. For survival data, key points made b…
View article: Clinical characteristics and predictors of complications and mortality in hospitalized octogenarian patients with COVID-19: an ambispective study
Clinical characteristics and predictors of complications and mortality in hospitalized octogenarian patients with COVID-19: an ambispective study Open
View article: Clinical Characteristics and Predictors of Complications and Mortality in Hospitalized Octogenarian Patients with COVID-19: An Ambispective Study
Clinical Characteristics and Predictors of Complications and Mortality in Hospitalized Octogenarian Patients with COVID-19: An Ambispective Study Open
Objective This study aimed to describe the clinical presentation of COVID-19 in hospitalized patients aged 80 or above and to identify predictors for death and complications throughout the epidemic waves of the disease. Methods This was an…
View article: Semi-Markov multistate modeling approaches for multicohort event history data
Semi-Markov multistate modeling approaches for multicohort event history data Open
Two Cox-based multistate modeling approaches are compared for analyzing a complex multicohort event history process. The first approach incorporates cohort information as a fixed covariate, thereby providing a direct estimation of the coho…
View article: Clinical Characteristics and Predictors of Complications and Mortality in Hospitalized Octogenarian Patients with COVID-19: An Ambispective Study (Preprint)
Clinical Characteristics and Predictors of Complications and Mortality in Hospitalized Octogenarian Patients with COVID-19: An Ambispective Study (Preprint) Open
BACKGROUND . OBJECTIVE This study aimed to describe the clinical presentation of COVID-19 in hospitalized patients aged 80 or above and to identify predictors for death and complications throughout the epidemic waves of the disease. M…
View article: Second Order Markov multistate models
Second Order Markov multistate models Open
Multistate models (MSM) are well developed for continuous and discrete times under a first order Markov assumption. Motivated by a cohort of COVID-19 patients, an MSM was designed based on 14 transitions among 7 states of a patient. Since …
View article: Design of Trials with Composite Endpoints with the R Package CompAREdesign
Design of Trials with Composite Endpoints with the R Package CompAREdesign Open
Composite endpoints are widely used as primary endpoints in clinical trials. Designing trials with time-to-event endpoints can be particularly challenging because the proportional hazard assumption usually does not hold when using a compos…
View article: In memory of Carmen María Cadarso Suárez (1960–2022)
In memory of Carmen María Cadarso Suárez (1960–2022) Open
View article: Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk
Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk Open
Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to invest…
View article: Adaptive clinical trial designs with blinded selection of binary composite endpoints and sample size reassessment
Adaptive clinical trial designs with blinded selection of binary composite endpoints and sample size reassessment Open
Summary For randomized clinical trials where a single, primary, binary endpoint would require unfeasibly large sample sizes, composite endpoints (CEs) are widely chosen as the primary endpoint. Despite being commonly used, CEs entail chall…
View article: Adaptive clinical trial designs with blinded selection of binary\n composite endpoints and sample size reassessment
Adaptive clinical trial designs with blinded selection of binary\n composite endpoints and sample size reassessment Open
For randomized clinical trials where a single, primary, binary endpoint would\nrequire unfeasibly large sample sizes, composite endpoints are widely chosen as\nthe primary endpoint. Despite being commonly used, composite endpoints entail\n…
View article: Descripción de la supervivencia con indicadores numéricos y gráficos. Conceptos básicos y errores que evitar
Descripción de la supervivencia con indicadores numéricos y gráficos. Conceptos básicos y errores que evitar Open
View article: Using the Geometric Average Hazard Ratio in Sample Size Calculation for Time-to-event Data With Composite Endpoints
Using the Geometric Average Hazard Ratio in Sample Size Calculation for Time-to-event Data With Composite Endpoints Open
Background: Sample size calculation is a key point in the design of a randomized controlled trial. With time-to-event outcomes, it’s often based on the logrank test. We provide a sample size calculation method for a composite endpoint (CE)…
View article: Modeling the Coronavirus Disease 2019 Incubation Period: Impact on Quarantine Policy
Modeling the Coronavirus Disease 2019 Incubation Period: Impact on Quarantine Policy Open
The incubation period of coronavirus disease 2019 (COVID-19) is not always observed exactly due to uncertain onset times of infection and disease symptom. In this paper, we demonstrate how to estimate the distribution of incubation and its…
View article: HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02)
HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02) Open
Kick&kill strategies combining drugs aiming to reactivate the viral reservoir with therapeutic vaccines to induce effective cytotoxic immune responses hold potential to achieve a functional cure for HIV-1 infection. Here, we report on an o…
View article: A general class of two-sample statistics for binary and time-to-event outcomes
A general class of two-sample statistics for binary and time-to-event outcomes Open
We propose a class of two-sample statistics for testing the equality of proportions and the equality of survival functions. We build our proposal on a weighted combination of a score test for the difference in proportions and a Weighted Ka…
View article: Decision tool and Sample Size Calculator for Composite Endpoints
Decision tool and Sample Size Calculator for Composite Endpoints Open
Summary points: - This article considers the combination of two binary or two time-to-event endpoints to form the primary composite endpoint for leading a trial. - It discusses the relative efficiency of choosing a composite endpoint over …
View article: Data Science in Biomedicine
Data Science in Biomedicine Open
We highlight the role of Data Science in Biomedicine. Our manuscript goes from the general to the particular, presenting a global definition of Data Science and showing the trend for this discipline together with the terms of cloud computi…
View article: Using the STROBE statement: survey findings emphasized the role of journals in enforcing reporting guidelines
Using the STROBE statement: survey findings emphasized the role of journals in enforcing reporting guidelines Open
Studies in Epidemiology (STROBE) statement, specifically authors’ attitudes toward and experiences with it. Study Design and Setting: An online survey was distributed to authors of observational studies recruited via social media, personal…
View article: Non-constant hazard ratios in randomized controlled trials with composite endpoints
Non-constant hazard ratios in randomized controlled trials with composite endpoints Open
The hazard ratio is routinely used as a summary measure to assess the treatment effect in clinical trials with time-to-event endpoints. It is frequently assumed as constant over time although this assumption often does not hold. When the h…
View article: Prevalence of Proteinuria in Owned Dogs from Italy: A Multicentric Study
Prevalence of Proteinuria in Owned Dogs from Italy: A Multicentric Study Open
Even though proteinuria is related to different causes, when it is persistent and associated with inactive urinary sediment, it is primarily due to kidney disease. Early detection of proteinuria allows us to identify several pathological c…
View article: Advanced Topics in Biostatistics: Editorial for the ISCB38 Special Issue
Advanced Topics in Biostatistics: Editorial for the ISCB38 Special Issue Open
This Special Issue on Advanced Topics in Biostatistics arose from the 38th Annual Conference of the International Society for Clinical Biostatistics (ISCB38), hosted by the city of Vigo (Spain), which took place from 9 to 13 July 2017. ISC…
View article: Genomic tools in the cloud: the new frontier in omics data analysis
Genomic tools in the cloud: the new frontier in omics data analysis Open
View article: A cross-sectional bibliometric study showed suboptimal journal endorsement rates of STROBE and its extensions
A cross-sectional bibliometric study showed suboptimal journal endorsement rates of STROBE and its extensions Open
Reporting guideline endorsement rates are low; information is vague and scattered. Unambiguous language is needed to improve adherence to reporting guidelines and increase the quality of reporting.
View article: High risk and probability of progression to osteoporosis at 10 years in HIV-infected individuals: the role of PIs
High risk and probability of progression to osteoporosis at 10 years in HIV-infected individuals: the role of PIs Open
Our results highlight the importance of monitoring bone mineral density given the high probability of progression to osteopenia/osteoporosis, especially in women. In the future, changes in antiretrovirals other than tenofovir, such as PIs,…
View article: Survival analysis model to estimate sensory shelf life with temperature and illumination as accelerating factors
Survival analysis model to estimate sensory shelf life with temperature and illumination as accelerating factors Open
View article: The STROBE extensions: protocol for a qualitative assessment of content and a survey of endorsement
The STROBE extensions: protocol for a qualitative assessment of content and a survey of endorsement Open
Introduction The STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) Statement was developed in response to inadequate reporting of observational studies. In recent years, several extensions to STROBE have been cr…