Guanfeng Lin
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View article: A novel single-vector featuring bidirectional promoters for production of bispecific antibody against rabies virus
A novel single-vector featuring bidirectional promoters for production of bispecific antibody against rabies virus Open
We developed peaSKYA single-vector expression system for robust production of bispecific antibodies, with candidate HHDVD exhibiting potential in Rabies PEP. This streamlined vector design approach exhibited remarkable potential in bispeci…
View article: Exposed nucleoprotein inside rabies virus particle as an ideal target for real-time quantitative evaluation of rabies virus particle integrity in vaccine quality control
Exposed nucleoprotein inside rabies virus particle as an ideal target for real-time quantitative evaluation of rabies virus particle integrity in vaccine quality control Open
Currently, the integrity of rabies virus particle in quality control can only be assessed through electron microscopy. However, its time-consuming nature, operational complexity, limited accuracy and lack of quantification capability no lo…
View article: Reduced SARS-CoV-2 Infection Rates in Lab Workers Conducting Nucleic Acid Testing: Controlling for the Healthy Worker Effect
Reduced SARS-CoV-2 Infection Rates in Lab Workers Conducting Nucleic Acid Testing: Controlling for the Healthy Worker Effect Open
A reduction in SARS-CoV-2 infections was observed among laboratory workers conducting SARS-CoV-2 NAT after controlling for the healthy worker effect. This finding has broader implications for understanding the role of natural immunity and …
View article: Simultaneous Quantitative Point-of-Care Detection of Nucleic Acid and Protein Biomarkers for Acute Myocardial Infarction Using Bright Aggregation-Induced Emission Nanoparticles
Simultaneous Quantitative Point-of-Care Detection of Nucleic Acid and Protein Biomarkers for Acute Myocardial Infarction Using Bright Aggregation-Induced Emission Nanoparticles Open
View article: Novel envelope protein time-resolved fluoroimmunoassay as an alternative in vitro potency assay for quality control of inactivated Japanese encephalitis virus vaccine
Novel envelope protein time-resolved fluoroimmunoassay as an alternative in vitro potency assay for quality control of inactivated Japanese encephalitis virus vaccine Open
Japanese encephalitis (JE) vaccination is the most effective way to prevent JE. Plaque reduction neutralization test (PRNT) as the standard method for potency testing for inactivated JE vaccine could not provide the exact potency value. En…
View article: A time-resolved fluorescence immunoassay for rapid and precise automatic quality control of human papillomavirus type 68 VLPs in human papillomavirus vaccine
A time-resolved fluorescence immunoassay for rapid and precise automatic quality control of human papillomavirus type 68 VLPs in human papillomavirus vaccine Open
The effectiveness and necessity of human papillomavirus (HPV) vaccination to prevent HPV infection and cervical cancer are increasingly recognized by people. The 15-valent HPV vaccine, which protects against almost high-risk types of HPV v…
View article: Ultrabright nanoparticle-labeled lateral flow immunoassay for detection of anti-SARS-CoV-2 neutralizing antibodies in human serum
Ultrabright nanoparticle-labeled lateral flow immunoassay for detection of anti-SARS-CoV-2 neutralizing antibodies in human serum Open
View article: Rapid Monitoring of Vancomycin Concentration in Serum Using Europium (III) Chelate Nanoparticle-Based Lateral Flow Immunoassay
Rapid Monitoring of Vancomycin Concentration in Serum Using Europium (III) Chelate Nanoparticle-Based Lateral Flow Immunoassay Open
Establishing personalized medication plans for patients to maximize therapeutic efficacy and minimize the toxicity of vancomycin (VAN) requires rapid, simple, and accurate monitoring of VAN concentration in body fluid. In this study, we ha…
View article: CRISPR-Based Diagnostic Method For Chlamydia Trachomatis in Patients With Non-Gonococcal Urethritis
CRISPR-Based Diagnostic Method For Chlamydia Trachomatis in Patients With Non-Gonococcal Urethritis Open
Non-gonococcal urethritis (NGU) is a type of urethritis that is transmitted by sexual contact. About 20%–50% of NGU cases are caused by Chlamydia trachomatis . Most NGU cases are asymptomatic, but failure to intervene promptly can lead to …
View article: Rapid and Sensitive Detection of anti-SARS-CoV-2 IgG, Using Lanthanide-Doped Nanoparticles-Based Lateral Flow Immunoassay
Rapid and Sensitive Detection of anti-SARS-CoV-2 IgG, Using Lanthanide-Doped Nanoparticles-Based Lateral Flow Immunoassay Open
The outbreak of 2019 coronavirus disease (COVID-19) has been a challenge for hospital laboratories because of the huge number of samples that must be tested for the presence of the causative pathogen, severe acute respiratory syndrome coro…
View article: Measurement of urinary matrix metalloproteinase-7 for early diagnosis of acute kidney injury based on an ultrasensitive immunomagnetic microparticle-based time-resolved fluoroimmunoassay
Measurement of urinary matrix metalloproteinase-7 for early diagnosis of acute kidney injury based on an ultrasensitive immunomagnetic microparticle-based time-resolved fluoroimmunoassay Open
The morbidity and mortality associated with acute kidney injury (AKI) remain obstinately high. Early diagnosis is urgently required and should be pursued in at-risk populations. Recently, a newly validated biomarker, matrix metalloproteina…
View article: Simple and rapid monitoring of doxorubicin using streptavidin-modified microparticle-based time-resolved fluorescence immunoassay
Simple and rapid monitoring of doxorubicin using streptavidin-modified microparticle-based time-resolved fluorescence immunoassay Open
Simple, rapid SA-MPs based TRFIA, is applied in therapeutic drug monitoring and the analytical performance is comparable with LC-MS/MS.
View article: Genotype and genetic variation of HCV infections with low-risk factors in Putian coastal regions, China
Genotype and genetic variation of HCV infections with low-risk factors in Putian coastal regions, China Open
SUMMARY Hepatitis C virus (HCV) infection is one of the leading causes of death and morbidity associated with liver disease. Risk factors identified for the transmission of HCV include contaminated blood products, intravenous drug use, bod…
View article: A time-resolved fluoroimmunoassay to assay the rabies virus glycoprotein: application for estimation of human rabies vaccine potency
A time-resolved fluoroimmunoassay to assay the rabies virus glycoprotein: application for estimation of human rabies vaccine potency Open
View article: Establishment of Magnetic Microparticles-Assisted Time-Resolved Fluoroimmunoassay for Determinating Biomarker Models in Human Serum
Establishment of Magnetic Microparticles-Assisted Time-Resolved Fluoroimmunoassay for Determinating Biomarker Models in Human Serum Open
In order to early screen and detect suspected biomarkers from pathogens and the human body itself, tracers or reaction strategies that can act as signal enhancers have been proposed forth at purpose. In this paper, we discussed the applica…
View article: Development of The Dual-labeling Time-resolved Fluoroimmunoassay for Detection of C-peptide and Insulin and Its Initially Application*
Development of The Dual-labeling Time-resolved Fluoroimmunoassay for Detection of C-peptide and Insulin and Its Initially Application* Open
肽与胰岛素双标记时间分辨荧光免疫分析法 的建立及初步临床应用
View article: Selection of cell lines for production of recombinant hepatitis C virus using the vaccinia virus expression system
Selection of cell lines for production of recombinant hepatitis C virus using the vaccinia virus expression system Open