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View article: Low-dose simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB
Low-dose simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB Open
Pancreatic cancer is typically accompanied by fibrosis, forming a dense stromal matrix. This dense matrix restricts drug penetration, making it difficult for drugs to effectively reach tumor cells. Additionally, pancreatic cancer has inade…
View article: Simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB
Simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB Open
Pancreatic cancer is typically accompanied by fibrosis, forming a dense stromal matrix. This dense matrix restricts drug penetration, making it difficult for drugs to effectively reach tumor cells. Additionally, pancreatic cancer has inade…
View article: IL15RA-STAT3-GPX4/ACSL3 signaling leads to ferroptosis resistance in pancreatic cancer
IL15RA-STAT3-GPX4/ACSL3 signaling leads to ferroptosis resistance in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a poor prognosis, and the lack of effective treatment methods accounts for its high mortality. Pancreatic stellate cells (PSCs) in the tumor microenvironment play a…
View article: PITX2 functions as a transcription factor for GPX4 and protects pancreatic cancer cells from ferroptosis
PITX2 functions as a transcription factor for GPX4 and protects pancreatic cancer cells from ferroptosis Open
Background Ferroptosis inhibits tumor progression in pancreatic cancer cells, while PITX2 is known to function as a pro-oncogenic factor in various tumor types, protecting them from ferroptosis and thereby promoting tumor progression. In t…
View article: Clinical outcomes of minimally invasive duodenum-preserving pancreatic head resection
Clinical outcomes of minimally invasive duodenum-preserving pancreatic head resection Open
Background The procedure of total duodenum-preserving pancreatic head resection (DPPHRt) has been reported frequently, but rare in minimally invasive procedure, especially robotic-assisted operation. Here we share our experience and analyz…
View article: PITX2 in pancreatic stellate cells promotes EMT in pancreatic cancer cells via the Wnt/β-catenin pathway
PITX2 in pancreatic stellate cells promotes EMT in pancreatic cancer cells via the Wnt/β-catenin pathway Open
Since the prognosis of patients with pancreatic cancer is very poor and there is a lack of treatment methods, this study is performed to investigate the function of PITX2 in pancreatic stellate cells (PSCs) in the progression of pancreatic…
View article: Additional file 1 of SETD8 inhibits ferroptosis in pancreatic cancer by inhibiting the expression of RRAD
Additional file 1 of SETD8 inhibits ferroptosis in pancreatic cancer by inhibiting the expression of RRAD Open
Additional file 1. The original figures of the western blot.
View article: Comparison of laparoscopic and open pancreaticoduodenectomy for the treatment of distal cholangiocarcinoma: A propensity score matching analysis
Comparison of laparoscopic and open pancreaticoduodenectomy for the treatment of distal cholangiocarcinoma: A propensity score matching analysis Open
Background There are few studies comparing the oncological outcomes of laparoscopic pancreaticoduodenectomy (LPD) and open pancreaticoduodenectomy (OPD) for distal cholangiocarcinoma (DCC). Our objective was to assess the short-term effica…
View article: A positive feedback loop of ARF6 activates ERK1/2 signaling pathway via <italic>DUSP6</italic> silencing to promote pancreatic cancer progression
A positive feedback loop of ARF6 activates ERK1/2 signaling pathway via <italic>DUSP6</italic> silencing to promote pancreatic cancer progression Open
ERK1/2 are essential proteins mediating mitogen-activated protein kinase signaling downstream of RAS in pancreatic adenocarcinoma (PDAC). Our previous study reveals that ARF6 plays a positive regulatory role in ERK1/2 pathway in a feedback…
View article: MicroRNA-708 inhibits the proliferation and chemoresistance of pancreatic cancer cells
MicroRNA-708 inhibits the proliferation and chemoresistance of pancreatic cancer cells Open
Pancreatic cancer is one of the most aggressive malignancies with poor prognosis and high mortality. Recent studies showed that microRNAs are dysregulated and involved in the initiation and progression of pancreatic cancer. In this study, …
View article: <p>Meta-analysis of the prognostic value of C-C chemokine receptor type 7 in patients with solid tumors</p>
Meta-analysis of the prognostic value of C-C chemokine receptor type 7 in patients with solid tumors Open
From this meta-analysis, we concluded that high expression of CCR7 in tumor tissue is associated with poor survival in patients with solid tumors, and may be a prognostic biomarker for tumor progression.