Guangcheng Wang
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View article: Genistein in the Prevention and Treatment of Periodontitis: A Review
Genistein in the Prevention and Treatment of Periodontitis: A Review Open
Periodontitis is a chronic and progressive inflammatory disease of periodontal tissue whose characteristic pathological changes include the destruction of periodontal soft tissue and the absorption of alveolar bone. Genistein, an isoflavon…
View article: Membrane‐Ion Interactions Creating Dual‐Nanoconfined Channels for Superior Mixed Ion Separations
Membrane‐Ion Interactions Creating Dual‐Nanoconfined Channels for Superior Mixed Ion Separations Open
Ion transport in environments with mixed ions is crucial for numerous real‐world applications. However, most membranes suffer from reduced selectivity in the mixed ion environment. Herein, the concept of dual‐nanoconfined channels in coval…
View article: A Responsive 3D Covalent Organic Framework Membrane with Tunable Pore Sizes for Molecular Sieving
A Responsive 3D Covalent Organic Framework Membrane with Tunable Pore Sizes for Molecular Sieving Open
3D covalent organic framework (3D COF) membranes with sub‐nanometer pore sizes and continuous channels offer a promising route for efficient molecular sieving. Nevertheless, fine‐tuning the pore sizes of dense COF membranes, especially tho…
View article: Mechanism Study On Machine learning-Based Process Optimization And Ethanol-Induced Performance Enhancement of Fe(Se,Te) Memristors
Mechanism Study On Machine learning-Based Process Optimization And Ethanol-Induced Performance Enhancement of Fe(Se,Te) Memristors Open
View article: The interaction effects between summer heat exposure and economic development on the settlement intention in floating population in China
The interaction effects between summer heat exposure and economic development on the settlement intention in floating population in China Open
View article: Novel carbazole-oxadiazole derivatives as anti-α-glucosidase and anti-α-amylase agents: Design, synthesis, molecular docking, and biological evaluation
Novel carbazole-oxadiazole derivatives as anti-α-glucosidase and anti-α-amylase agents: Design, synthesis, molecular docking, and biological evaluation Open
View article: Local manipulation of skyrmion lattice in Fe3GaTe2 at room temperature
Local manipulation of skyrmion lattice in Fe3GaTe2 at room temperature Open
Motivated by advances in spintronic devices, extensive explorations are underway to uncover materials that host topologically protected spin textures, exemplified by skyrmions. One critical challenge involved in the potential application o…
View article: Local Manipulation of Skyrmion Lattice in Fe3GaTe2 at Room Temperature
Local Manipulation of Skyrmion Lattice in Fe3GaTe2 at Room Temperature Open
Motivated by advances in spintronic devices, an extensive exploration is underway to uncover materials that host topologically protected spin textures, exemplified by skyrmions. One critical challenge involved in the potential application …
View article: Synthesis, anti-browning effect and mechanism research of kojic acid-coumarin derivatives as anti-tyrosinase inhibitors
Synthesis, anti-browning effect and mechanism research of kojic acid-coumarin derivatives as anti-tyrosinase inhibitors Open
Thirteen kojic acid-coumarin derivatives were synthesized using the principle of molecular hybridization, and their structures were characterized by 1H NMR, 13C NMR, and HRMS. In vitro enzyme inhibition experiments showed that all newly sy…
View article: Synthesis, biological evaluation and action mechanism of 7H-[1,2,4] triazolo [3,4-b] [1,3,4] thiadiazine-phenylhydrazone derivatives as α-glucosidase inhibitors
Synthesis, biological evaluation and action mechanism of 7H-[1,2,4] triazolo [3,4-b] [1,3,4] thiadiazine-phenylhydrazone derivatives as α-glucosidase inhibitors Open
View article: Association between PM<sub>2.5</sub> and hypertension among the floating population in China: a cross-sectional study
Association between PM<sub>2.5</sub> and hypertension among the floating population in China: a cross-sectional study Open
Few studies have investigated the association between PM2.5 and hypertension among floating populations. We therefore examined the relationship using binary logistic regression. Each grade of increment in the annual average PM
View article: Supercritical carbon dioxide/nitrogen/air extraction with multistage stripping enables selective recovery of rare earth elements from coal fly ashes
Supercritical carbon dioxide/nitrogen/air extraction with multistage stripping enables selective recovery of rare earth elements from coal fly ashes Open
Using supercritical fluids, our novel process selectively extracts rare earth elements from coal fly ashes that were previously considered as waste and an environmental threat.
View article: Tyrosinase inhibitory mechanism and anti-browning properties of novel kojic acid derivatives bearing aromatic aldehyde moiety
Tyrosinase inhibitory mechanism and anti-browning properties of novel kojic acid derivatives bearing aromatic aldehyde moiety Open
Kojic acid-aromatic aldehydes 6a-6m were synthesized and screened for their anti-tyrosinase activities. These compounds showed potently anti-tyrosinase activity with IC50 values in the range of 5.32 ± 0.23 to 77.89…
View article: An overview: metal-based inhibitors of urease
An overview: metal-based inhibitors of urease Open
Urease is a kind of nickel-dependent metalloenzyme, which exists in the biological world widely, and can catalyse the hydrolysis of urea into ammonia and carbon dioxide to provide a nitrogen source for organisms. Urease has important uses …
View article: Synthesis, α-glucosidase inhibition and molecular docking studies of natural product 2-(2-phenyethyl)chromone analogues
Synthesis, α-glucosidase inhibition and molecular docking studies of natural product 2-(2-phenyethyl)chromone analogues Open
A series of natural product (2-phenyethyl)chromone analogues (3–34) were designed, synthesized, and screened for their α-glucosidase inhibitory activity. The results indicated that some of the synthesized derivatives displayed inhibitory a…
View article: Synthesis and antitumor activity of litseaone B analogues as tubulin polymerisation inhibitors
Synthesis and antitumor activity of litseaone B analogues as tubulin polymerisation inhibitors Open
A series of litseaone B analogues 4a∼4p were synthesised and antitumor activities of all compounds were screened. These compounds were designed by introducing different substituents on the B ring. Among these synthesised compounds, …
View article: The Associations between Exposure to PM2.5 Air Pollution and Incidence of Cardiovascular Disease in Yantai, China
The Associations between Exposure to PM2.5 Air Pollution and Incidence of Cardiovascular Disease in Yantai, China Open
Numerous epidemiological studies have demonstrated that atmospheric particulate matter, especially PM 2.5 , is closely related to cardiovascular disease. But few studies investigated the association between short-term exposure to PM 2.5 an…
View article: Occurrence, synthesis and biological activity of 2-(2-phenyethyl)chromones
Occurrence, synthesis and biological activity of 2-(2-phenyethyl)chromones Open
View article: A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors
A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors Open
Microtubules play an important role in the process of cell mitosis and can form a spindle in the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then divide into two daughter cells to complete the proce…
View article: Design, synthesis and biological evaluation of novel 2-phenyl-4,5,6,7-tetrahydro-1H-indole derivatives as potential anticancer agents and tubulin polymerization inhibitors
Design, synthesis and biological evaluation of novel 2-phenyl-4,5,6,7-tetrahydro-1H-indole derivatives as potential anticancer agents and tubulin polymerization inhibitors Open
A new series of 2-phenyl-4,5,6,7-tetrahydro-1H-indole derivatives as tubulin polymerization inhibitors were synthesized and evaluated for the anti-proliferative activities. All newly prepared compounds were tested for their antiproliferat…
View article: An overview of hydroxypyranone and hydroxypyridinone as privileged scaffolds for novel drug discovery
An overview of hydroxypyranone and hydroxypyridinone as privileged scaffolds for novel drug discovery Open
View article: Synthesis, biological evaluation and molecular docking investigation of new sulphonamide derivatives bearing naphthalene moiety as potent tubulin polymerisation inhibitors
Synthesis, biological evaluation and molecular docking investigation of new sulphonamide derivatives bearing naphthalene moiety as potent tubulin polymerisation inhibitors Open
A new series of sulphonamide derivatives bearing naphthalene moiety were synthesised and evaluated for their antiproliferative and tubulin polymerisation inhibitory activities. These new compounds were evaluated for their in vitro a…
View article: Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors
Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors Open
A novel series of thiazole-naphthalene derivatives as tubulin polymerisation inhibitors were designed, synthesised, and evaluated for the anti-proliferative activities. The majority of the tested compounds exhibited moderate to potent anti…
View article: Design, Synthesis and Biological Evaluation of Novel 4-(4-Methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines as Tubulin Polymerization Inhibitors
Design, Synthesis and Biological Evaluation of Novel 4-(4-Methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines as Tubulin Polymerization Inhibitors Open
A novel series of 4-(4-methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines were designed, synthesized, and evaluated for their anticancer activities. Most of the synthesized compounds exhibited moderate to high antiproliferative activity in c…
View article: Design, synthesis and biological evaluation of isoxazole-naphthalene derivatives as anti-tubulin agents
Design, synthesis and biological evaluation of isoxazole-naphthalene derivatives as anti-tubulin agents Open
In this study, a novel series of isoxazole-naphthalene derivatives as tubulin polymerization inhibitors were designed, synthesized and evaluated for their anti-proliferative activities against human breast cancer cell line MCF-7. Most of t…
View article: Tissue Distribution Comparison of Six Active Ingredients from an Eucommiae Cortex Extract between Normal and Spontaneously Hypertensive Rats
Tissue Distribution Comparison of Six Active Ingredients from an Eucommiae Cortex Extract between Normal and Spontaneously Hypertensive Rats Open
Eucommiae Cortex (EC), a rare, nourishing medicinal herb that is native in China, has good effect in the treatment of hypertension. In this study, we compared tissue distribution of six representative active components of EC extract—genipi…
View article: Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site
Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site Open
A series of naphthalene-chalcone derivatives (3a–3t) were prepared and evaluated as tubulin polymerisation inhibitor for the treatment of breast cancer. All compounds were evaluated for their antiproliferative activity against MCF-7…
View article: Synthesis, Anticancer Activity and Molecular Modeling Studies of Novel Chalcone Derivatives Containing Indole and Naphthalene Moieties as Tubulin Polymerization Inhibitors
Synthesis, Anticancer Activity and Molecular Modeling Studies of Novel Chalcone Derivatives Containing Indole and Naphthalene Moieties as Tubulin Polymerization Inhibitors Open
Eighteen novel chalcone derivatives containing indole and naphthalene moieties (2-19) were synthesized and characterized by 1H-NMR, 13C-NMR and high resolution (HR)-MS spectra. All compounds were evaluated for their in vitro cytotoxic pote…
View article: In Vivo and In Vitro Anti-Arthritic Effects of Cardenolide-Rich and Caffeoylquinic Acid-Rich Fractions of Periploca forrestii
In Vivo and In Vitro Anti-Arthritic Effects of Cardenolide-Rich and Caffeoylquinic Acid-Rich Fractions of Periploca forrestii Open
Periploca forrestii Schltr. (P. forrestii) is a species used in Traditional Chinese Medicine (TCM) known as “Miao medicine”, and has a long history of use in the treatment of rheumatism, rheumatoid arthritis (RA), and joint pain. The prese…
View article: Effects of Soil Water Deficit on Insecticidal Protein Expression in Boll Shells of Transgenic Bt Cotton and the Mechanism
Effects of Soil Water Deficit on Insecticidal Protein Expression in Boll Shells of Transgenic Bt Cotton and the Mechanism Open
This study was conducted to investigate the effects of soil water deficit on insecticidal protein expression in boll shells of cotton transgenic for a Bt gene. In 2014, Bt cotton cultivars Sikang 1 (a conventional cultivar) and Sikang 3 (a…