Guanggui Ding
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View article: Artificial intelligence in thoracic surgery: Perspectives and challenges
Artificial intelligence in thoracic surgery: Perspectives and challenges Open
View article: Adjuvant icotinib for resected EGFR-mutated stage II–IIIA non-small-cell lung cancer (ICTAN, GASTO1002): a randomized comparison study
Adjuvant icotinib for resected EGFR-mutated stage II–IIIA non-small-cell lung cancer (ICTAN, GASTO1002): a randomized comparison study Open
The efficacy, safety and ideal treatment duration of an adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for patients with resected EGFR-mutated non-small-cell lung cancer (NSCLC) were not known until 2014, wh…
View article: City scale related to epidermal growth factor receptor mutations status in Chinese non-small cell lung cancer
City scale related to epidermal growth factor receptor mutations status in Chinese non-small cell lung cancer Open
Although there is a correlation between the size of a city and the rates of EGFR mutations in Chinese NSCLC patients, city scale does not independently predict these mutation rates. Instead, the variations in EGFR mutation rates could be i…
View article: Tissue-wide profiling of human lungs reveals spatial sequestration of macrophages in tuberculosis
Tissue-wide profiling of human lungs reveals spatial sequestration of macrophages in tuberculosis Open
The immune response to human tuberculosis (TB), particularly in the context of complex lung pathology, remains incompletely understood. Here, we employed whole-slide spatial proteomics to map immune cell organization in TB-affected human l…
View article: Adjuvant icotinib of 12 months or 6 months versus observation following adjuvant chemotherapy for resected EGFR-mutated stage II–IIIA non-small cell lung cancer (ICTAN, GASTO1002): a randomized phase 3 trial
Adjuvant icotinib of 12 months or 6 months versus observation following adjuvant chemotherapy for resected EGFR-mutated stage II–IIIA non-small cell lung cancer (ICTAN, GASTO1002): a randomized phase 3 trial Open
The efficacy, safety and ideal treatment duration of an adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for patients with completely resected EGFR-mutated non-small cell lung cancer (NSCLC) after adjuvant che…
View article: Myriocin enhances the clearance of <i>M. tuberculosis</i> by macrophages through the activation of PLIN2
Myriocin enhances the clearance of <i>M. tuberculosis</i> by macrophages through the activation of PLIN2 Open
Myriocin is an inhibitor of de novo synthesis of sphingolipids and ceramides. In this research, we showed myriocin could significantly reduce Mtb burden and histopathological inflammation in mice. However, the underlying mechanism remains …
View article: Bowel habits were associated with mortality in chronic kidney disease: results from a nationwide prospective cohort study
Bowel habits were associated with mortality in chronic kidney disease: results from a nationwide prospective cohort study Open
Bowel habits may affect the prognosis in the chronic kidney disease (CKD) patients. This study aimed to explore the association of bowel habits with cardiovascular and all-cause mortality in CKD. 2460 CKD patients in the National Health an…
View article: Potential Biomarkers and Resistance Mechanisms of Atezolizumab in a Patient with Lung Squamous Cell Carcinoma
Potential Biomarkers and Resistance Mechanisms of Atezolizumab in a Patient with Lung Squamous Cell Carcinoma Open
Background: At present, only a small fraction of patients with cancer benefit from treatment with immune checkpoint inhibitors, the reasons for which are not fully understood. Monitoring molecular and immunologic changes during trea…
View article: Long-Term Survival After Salvage Thoracic Surgery on a Patient with ALK-Rearranged Metastatic Lung Adenocarcinoma After Progression on Targeted Therapy
Long-Term Survival After Salvage Thoracic Surgery on a Patient with ALK-Rearranged Metastatic Lung Adenocarcinoma After Progression on Targeted Therapy Open
Targeted therapy for patients with advanced non-small cell lung cancer (NSCLC) is often challenged by the arising of drug resistance. After progression to targeted therapy, treatment options include continued targeted therapy, definitive l…
View article: Circular RNA hsa_circ_0002483 promotes growth and invasion of lung adenocarcinoma by sponging miR-125a-3p
Circular RNA hsa_circ_0002483 promotes growth and invasion of lung adenocarcinoma by sponging miR-125a-3p Open
Background Increasing evidence indicates that the aberrant expression of circular RNAs (circRNAs) is involved in the pathogenesis and progression of lung adenocarcinoma (LUAC). However, the function and molecular mechanisms of hsa_circ_000…
View article: Circular RNA Hsa_Circ_0002483 Promotes Growth and Invasion of Lung Adenocarcinoma by Sponging miR-125a-3p
Circular RNA Hsa_Circ_0002483 Promotes Growth and Invasion of Lung Adenocarcinoma by Sponging miR-125a-3p Open
Background: Increasing evidence indicates that the aberrant expression of circular RNAs (circRNAs) is involved in the pathogenesis and progression of lung adenocarcinoma (LUAC). However, the function and molecular mechanisms of hsa_circ_00…
View article: Thermal treatment decreases resistance to osimertinib in non-small cell lung cancer through the EGFR/PI3K/AKT pathway
Thermal treatment decreases resistance to osimertinib in non-small cell lung cancer through the EGFR/PI3K/AKT pathway Open
Osimertinib (OSI) resistance commonly occurs during the treatment of non-small-cell lung cancer (NSCLC). This study aims to investigate whether the thermal effects of radiofrequency ablation (RFA) can increase the sensitivity of OSI-resist…
View article: Inhibitory effect of Ubenimex combined with fluorouracil on multiple drug resistance and P‐glycoprotein expression level in non‐small lung cancer
Inhibitory effect of Ubenimex combined with fluorouracil on multiple drug resistance and P‐glycoprotein expression level in non‐small lung cancer Open
Tumour drug resistance is one of the most urgent issues faced by anti‐tumour therapies. P‐glycoprotein (P‐gp) has been reported to be correlated with drug resistance. In this study, we aimed to study the synergistic effect of fluorouracil …
View article: miR‑10a increases the cisplatin resistance of lung adenocarcinoma circulating tumor cells via targeting PIK3CA in the PI3K/Akt pathway
miR‑10a increases the cisplatin resistance of lung adenocarcinoma circulating tumor cells via targeting PIK3CA in the PI3K/Akt pathway Open
Circulating tumor cells (CTCs) that are shed from the primary tumor invade the blood stream or surrounding parenchyma to form new tumors. The present study aimed to explore the underlying mechanism of cisplatin resistance in lung adenocarc…
View article: Independent prognostic value of HIF‑1α expression in radiofrequency ablation of lung cancer
Independent prognostic value of HIF‑1α expression in radiofrequency ablation of lung cancer Open
Radiofrequency ablation (RFA) is widely used in the treatment of lung cancer. Hypoxia-inducible factor-1α (HIF-1α) is a crucial transcription factor regulating oxygen homeostasis that is involved in tumor cell metastasis. The present study…
View article: Case report: HER2 amplification as a resistance mechanism to crizotinib in NSCLC with MET exon 14 skipping
Case report: HER2 amplification as a resistance mechanism to crizotinib in NSCLC with MET exon 14 skipping Open
Patients with non-small cell lung cancer (NSCLC) harboring MET exon 14 skipping can benefit from crizotinib treatment. Currently, the main resistance mechanisms to crizotinib are MET D1228N and Y1230C mutations. We reported a case of a Chi…
View article: miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway
miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway Open
The present study aimed to evaluate the function of microRNA (miR)-142-5p on cancer immunity to induce apoptosis in human non-small cell lung cancer (NSCLC) and its mechanism. miR-142-5p expression was upregulated, and CD4+ T cell levels w…
View article: Efficacy generated by afatinib in a lung adenocarcinoma patient harboring <i>HER2</i> S310Y mutation
Efficacy generated by afatinib in a lung adenocarcinoma patient harboring <i>HER2</i> S310Y mutation Open
Afatinib exhibits therapeutic efficacy for lung adenocarcinoma patients harboring HER2 exon 20 insertions. HER2 S310Y single site substitution was discovered in recent years and afatinib efficacy for adenocarcinoma patients harboring S310Y…
View article: Inhibition of Skp2 sensitizes lung cancer cells to paclitaxel
Inhibition of Skp2 sensitizes lung cancer cells to paclitaxel Open
S-phase kinase-associated protein 2 (Skp2) is an E3 ubiquitin ligase and plays an important role in the control of cell cycle progression. Skp2 is upregulated in several cancers, including lung cancers, but the role of Skp2 in the tumorige…
View article: Upregulated lncRNA H19 promotes non-small cell lung cancer cell proliferation through miR-138/PDK1 axis.
Upregulated lncRNA H19 promotes non-small cell lung cancer cell proliferation through miR-138/PDK1 axis. Open
Long non-coding RNA (lncRNA) H19 was reported to be aberrantly expressed and implicated in non-small cell lung cancer (NSCLC). However, the regulation of NSCLC progression by H19 was not well understood. In this study, we found that the ex…
View article: Uniportal video-assisted thoracoscopic anatomic segmentectomy for small-sized lung cancer
Uniportal video-assisted thoracoscopic anatomic segmentectomy for small-sized lung cancer Open
Increasing evidences prove video-assisted thoracic surgery (VATS) segmentectomy is accepted as a valid alternative to lobectomy esp. a greater number of small lung nodules have been detected. Uniportal VATS segmentectomy for small-sized lu…
View article: S-phase kinase-associated protein 2 positively controls mitotic arrest deficient 2 in lung cancer cells
S-phase kinase-associated protein 2 positively controls mitotic arrest deficient 2 in lung cancer cells Open
Background . Mitotic arrest deficient 2 (Mad2) is a key component of spindle assembly checkpoint and overexpressed in human lung cancers, but the mechanism of the deregulation of Mad2 in lung cancer is largely unknown. We aim to investigat…
View article: S-phase kinase-associated protein 2 positively controls mitotic arrest deficient 2 in lung cancer cells
S-phase kinase-associated protein 2 positively controls mitotic arrest deficient 2 in lung cancer cells Open
Background . Mitotic arrest deficient 2 (Mad2) is a key component of spindle assembly checkpoint and overexpressed in human lung cancers, but the mechanism of the deregulation of Mad2 in lung cancer is largely unknown. We aim to investigat…
View article: Uniportal complete video-assisted thoracoscopic surgery lobectomy with partial pulmonary arterioplasty for lung cancer with calcified lymph node.
Uniportal complete video-assisted thoracoscopic surgery lobectomy with partial pulmonary arterioplasty for lung cancer with calcified lymph node. Open
Now, more and more complete video-assisted thoracoscopic surgery (cVATS) surgeons are capable of performing lobectomy by uniportal approach. However, concerns regarding the safety of uniportal procedures for complex cases such as neoadjuva…
View article: On the linearly isometric extension problem
On the linearly isometric extension problem Open
In this paper, we introduce two extension problems of isometric mappings between unit spheres of two normed spaces and list some important results and recent progress of the related problems.