Guanghai Zhao
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View article: Brucella melitensis clinical isolate modulates osteoclast differentiation to drive pathological bone destruction in brucellar arthritis
Brucella melitensis clinical isolate modulates osteoclast differentiation to drive pathological bone destruction in brucellar arthritis Open
Background Brucellosis is a widespread zoonosis that is acquired by humans from infected animals. Articular complications, particularly brucellar spondylitis, are the most prevalent and disabling manifestations of human brucellosis. Inflam…
View article: A Novel Long-Term Intrathecal Cannulation Technique in Rats: L5-L6 Approach With Cervical Externalization for Chronic Drug Delivery
A Novel Long-Term Intrathecal Cannulation Technique in Rats: L5-L6 Approach With Cervical Externalization for Chronic Drug Delivery Open
Background and Purpose: Current intrathecal (IT) catheter techniques in rats are problematic due to complex surgical procedures and frequent blockages. This study developed a simpler, faster, and more reliable method for long-term IT cathe…
View article: Chronotherapy and intervertebral disc degeneration: understanding the role of circadian rhythm in degenerative processes
Chronotherapy and intervertebral disc degeneration: understanding the role of circadian rhythm in degenerative processes Open
Intervertebral disc degeneration (IDD) and low back pain are prevalent issues globally, affecting a significant portion of the adult population. Recent research has highlighted the crucial role of circadian rhythms in the degenerative proc…
View article: Brucella osteoarthritis: recent progress and future directions
Brucella osteoarthritis: recent progress and future directions Open
Brucellosis is a common zoonosis, and Brucella osteoarthritis is the most common chronic complication of brucellosis. Development of brucellosis osteoarthritis involves multiple organs, tissues, and cells. Brucella grows and multiplies in …
View article: The Role of Ubiquitination in Osteosarcoma Development and Therapies
The Role of Ubiquitination in Osteosarcoma Development and Therapies Open
The ubiquitin–proteasome system (UPS) maintains intracellular protein homeostasis and cellular function by regulating various biological processes. Ubiquitination, a common post-translational modification, plays a crucial role in the regul…
View article: TGF‐β1 Inhibits Osteoclast Differentiation and Abnormal Angiogenesis in Intervertebral Disc Degeneration: Evidence from RNA Sequencing and Animal Studies
TGF‐β1 Inhibits Osteoclast Differentiation and Abnormal Angiogenesis in Intervertebral Disc Degeneration: Evidence from RNA Sequencing and Animal Studies Open
Objective Mechanisms involved in developing intervertebral disc degeneration (IDD) are poorly understood, thus making developing effective therapies difficult. This study aimed to suggest a possible molecular mechanism, based on transcript…
View article: Bibliometric and visual analysis of microglia-related neuropathic pain from 2000 to 2021
Bibliometric and visual analysis of microglia-related neuropathic pain from 2000 to 2021 Open
Background Microglia has gradually gained researchers’ attention in the past few decades and has shown its promising prospect in treating neuropathic pain. Our study was performed to comprehensively evaluate microglia-related neuropathic p…
View article: Curcumin Exerts Antinociceptive Effects in Cancer-Induced Bone Pain via an Endogenous Opioid Mechanism
Curcumin Exerts Antinociceptive Effects in Cancer-Induced Bone Pain via an Endogenous Opioid Mechanism Open
Cancer pain is one of the main complications in advanced cancer patients, and its management is still challenging. Therefore, there is an urgent need to develop novel pharmacotherapy for cancer pain. Several natural products have attracted…
View article: Cervical spinal tuberculosis combined with brucellosis
Cervical spinal tuberculosis combined with brucellosis Open
Introduction: In some developing countries, tuberculosis and brucellosis, which are commom causes of spinal infections, are still common infectious diseases. However, co-occurrence of spinal tuberculosis and brucellosis is rare.
Methodolo…
View article: [Research progress on the role of adipokines in intervertebral disc degeneration].
[Research progress on the role of adipokines in intervertebral disc degeneration]. Open
Adipokines, as a biologically active substance with metabolic and immunomodulatory functions, play important roles in the occurrence, development, and biological treatment of IVDD.