Guangliang Ding
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View article: Vascular Contribution to Cerebral Waste Clearance Affected by Aging or Diabetes
Vascular Contribution to Cerebral Waste Clearance Affected by Aging or Diabetes Open
Background: The brain’s vascular system has recently been shown to provide an important efflux pathway for cerebral waste clearance (CWC). However, little is known about the influence of aging or diabetes on the CWC. The aim of the current…
View article: Lower Limb Coordination for Barefoot Running at Different Running Speeds in Overweight Populations
Lower Limb Coordination for Barefoot Running at Different Running Speeds in Overweight Populations Open
View article: Velocity of cerebrospinal fluid in the aqueduct measured by phase‐contrast MRI in rat
Velocity of cerebrospinal fluid in the aqueduct measured by phase‐contrast MRI in rat Open
Cerebrospinal fluid (CSF) circulation plays a key role in cerebral waste clearance via the glymphatic system. Although CSF flow velocity is an essential component of CSF dynamics, it has not been sufficiently characterized, and particularl…
View article: The Association between Glymphatic System and Perivascular Macrophages in Brain Waste Clearance
The Association between Glymphatic System and Perivascular Macrophages in Brain Waste Clearance Open
The glymphatic system suggests the convective bulk flow of cerebrospinal fluid (CSF) through perivascular spaces and the interstitial spaces of the brain parenchyma for the rapid removal of toxic waste solutes from the brain. However, the …
View article: Clinical magnetic resonance imaging evaluation of glymphatic function
Clinical magnetic resonance imaging evaluation of glymphatic function Open
The glymphatic system is a system of specialized perivascular spaces in the brain that facilitates removal of toxic waste solutes from the brain. Evaluation of glymphatic system function by means of magnetic resonance imaging (MRI) has thu…
View article: The Glymphatic Response to the Development of Type 2 Diabetes
The Glymphatic Response to the Development of Type 2 Diabetes Open
The glymphatic system has recently been shown to be important in neurological diseases, including diabetes. However, little is known about how the progressive onset of diabetes affects the glymphatic system. The aim of this study is to inv…
View article: Imaging glymphatic response to glioblastoma
Imaging glymphatic response to glioblastoma Open
View article: The Association between Glymphatic System and Perivascular Macrophages in Brain Waste Clearance
The Association between Glymphatic System and Perivascular Macrophages in Brain Waste Clearance Open
The glymphatic system suggests the convective bulk flow of cerebrospinal fluid (CSF) through perivascular spaces and the interstitial spaces of the brain parenchyma for the rapid removal of toxic waste solutes from the brain. However, the …
View article: Glymphatic transport is reduced in rats with spontaneous pituitary tumor
Glymphatic transport is reduced in rats with spontaneous pituitary tumor Open
Background and objective Pituitary tumor in patients induces adverse alterations in the brain, accompanied by cognitive deficits. Dysfunction of glymphatic waste clearance results in accumulation of neurotoxic products within the brain, le…
View article: Aging-Related Alterations of Glymphatic Transport in Rat: In vivo Magnetic Resonance Imaging and Kinetic Study
Aging-Related Alterations of Glymphatic Transport in Rat: In vivo Magnetic Resonance Imaging and Kinetic Study Open
Objective Impaired glymphatic waste clearance function during brain aging leads to the accumulation of metabolic waste and neurotoxic proteins (e.g., amyloid-β, tau) which contribute to neurological disorders. However, how the age-related …
View article: MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes Open
Ongoing neurovascular dysfunction contributes to type 2 diabetes mellitus (T2DM)-induced cognitive deficits. However, it is not known whether early post onset of T2DM interventions may reduce evolving neurovascular dysfunction and thereby …
View article: Waste Clearance in the Brain
Waste Clearance in the Brain Open
Waste clearance (WC) is an essential process for brain homeostasis, which is required for the proper and healthy functioning of all cerebrovascular and parenchymal brain cells. This review features our current understanding of brain WC, bo…
View article: Cerebral endothelial cell-derived small extracellular vesicles enhance neurovascular function and neurological recovery in rat acute ischemic stroke models of mechanical thrombectomy and embolic stroke treatment with tPA
Cerebral endothelial cell-derived small extracellular vesicles enhance neurovascular function and neurological recovery in rat acute ischemic stroke models of mechanical thrombectomy and embolic stroke treatment with tPA Open
Treatment of patients with cerebral large vessel occlusion with thrombectomy and tissue plasminogen activator (tPA) leads to incomplete reperfusion. Using rat models of embolic and transient middle cerebral artery occlusion (eMCAO and tMCA…
View article: MRI detection of impairment of glymphatic function in rat after mild traumatic brain injury
MRI detection of impairment of glymphatic function in rat after mild traumatic brain injury Open
View article: Magnetic Resonance Imaging and Modeling of the Glymphatic System
Magnetic Resonance Imaging and Modeling of the Glymphatic System Open
The glymphatic system is a newly discovered waste drainage pathway in the brain; it plays an important role in many neurological diseases. Ongoing research utilizing various cerebrospinal fluid tracer infusions, either directly or indirect…
View article: Differences between normal and diabetic brains in middle-aged rats by MRI
Differences between normal and diabetic brains in middle-aged rats by MRI Open
View article: Diffuse white matter response in trauma-injured brain to bone marrow stromal cell treatment detected by diffusional kurtosis imaging
Diffuse white matter response in trauma-injured brain to bone marrow stromal cell treatment detected by diffusional kurtosis imaging Open
View article: MRI investigation of glymphatic responses to Gd‐DTPA infusion rates
MRI investigation of glymphatic responses to Gd‐DTPA infusion rates Open
The glymphatic system is a newly identified waste clearance pathway in brain discovered and investigated predominately using in vivo two‐photon confocal microscopy. Magnetic resonance imaging (MRI), in contrast to two‐photon confocal micro…
View article: Noninvasive measurement of renal blood flow by magnetic resonance imaging in rats
Noninvasive measurement of renal blood flow by magnetic resonance imaging in rats Open
Renal blood flow (RBF) provides important information regarding renal physiology and nephropathies. Arterial spin labeling–magnetic resonance imaging (ASL-MRI) is a noninvasive method of measuring blood flow without exogenous contrast medi…
View article: Chronic global analysis of vascular permeability and cerebral blood flow after bone marrow stromal cell treatment of traumatic brain injury in the rat: A long-term MRI study
Chronic global analysis of vascular permeability and cerebral blood flow after bone marrow stromal cell treatment of traumatic brain injury in the rat: A long-term MRI study Open
View article: Impairment of the glymphatic system after diabetes
Impairment of the glymphatic system after diabetes Open
The glymphatic system has recently been shown to clear brain extracellular solutes and abnormalities in glymphatic clearance system may contribute to both initiation and progression of neurological diseases. Despite that diabetes is known …
View article: Diffusion-Derived Magnetic Resonance Imaging Measures of Longitudinal Microstructural Remodeling Induced by Marrow Stromal Cell Therapy after Traumatic Brain Injury
Diffusion-Derived Magnetic Resonance Imaging Measures of Longitudinal Microstructural Remodeling Induced by Marrow Stromal Cell Therapy after Traumatic Brain Injury Open
Using magnetic resonance imaging (MRI) and an animal model of traumatic brain injury (TBI), we investigated the capacity and sensitivity of diffusion-derived measures, fractional anisotropy (FA), and diffusion entropy, to longitudinally id…
View article: Cell Treatment for Stroke in Type Two Diabetic Rats Improves Vascular Permeability Measured by MRI
Cell Treatment for Stroke in Type Two Diabetic Rats Improves Vascular Permeability Measured by MRI Open
Treatment of stroke with bone marrow stromal cells (BMSC) significantly enhances brain remodeling and improves neurological function in non-diabetic stroke rats. Diabetes is a major risk factor for stroke and induces neurovascular changes …
View article: White matter changes after stroke in type 2 diabetic rats measured by diffusion magnetic resonance imaging
White matter changes after stroke in type 2 diabetic rats measured by diffusion magnetic resonance imaging Open
Diffusion-related magnetic resonance imaging parametric maps may be employed to characterize white matter of brain. We hypothesize that entropy of diffusion anisotropy may be most effective for detecting therapeutic effects of bone marrow …
View article: Focal embolic cerebral ischemia in the rat
Focal embolic cerebral ischemia in the rat Open