Guanglin He
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View article: Differentiated genomic footprints and connections inferred from 440 Hmong-Mien genomes suggest their isolation and long-distance migration
Differentiated genomic footprints and connections inferred from 440 Hmong-Mien genomes suggest their isolation and long-distance migration Open
Background: The underrepresentation of Hmong-Mien (HM) people in Asian genomic studies has hindered our comprehensive understanding of the full landscape of their evolutionary history and complex trait architecture. South China is a multi-…
View article: Differentiated genomic footprints and connections inferred from 440 Hmong-Mien genomes suggest their isolation and long-distance migration
Differentiated genomic footprints and connections inferred from 440 Hmong-Mien genomes suggest their isolation and long-distance migration Open
Background: The underrepresentation of Hmong-Mien (HM) people in Asian genomic studies has hindered our comprehensive understanding of the full landscape of their evolutionary history and complex t…
View article: Integrated genetic and geographic ancestry prediction via large-scale genomic data and machine learning
Integrated genetic and geographic ancestry prediction via large-scale genomic data and machine learning Open
View article: Short tandem repeats in populations of the Qinghai-Tibet Plateau and adjacent regions provide insights into high-altitude adaptation
Short tandem repeats in populations of the Qinghai-Tibet Plateau and adjacent regions provide insights into high-altitude adaptation Open
Short tandem repeats (STRs) confer evolutionary advantages across various species, yet their roles in human high-altitude adaptation remain largely unexplored. In this study, we analyzed over 1.1 million STRs in 7876 whole-genome sequencin…
View article: Genomic insights into population structure, adaptation, and archaic introgression at the Himalayan–East Asian crossroads
Genomic insights into population structure, adaptation, and archaic introgression at the Himalayan–East Asian crossroads Open
Tibetan-Yi Corridor (TYC) is a crucial agro-pastoral region in the eastern Himalayas, linking Qinghai‒Xizang Plateau with the lowlands of East Asia and facilitating human migration for millennia. However, genomic research on TYC population…
View article: Largest-Scale Genomic Resource Reconstructing the Genetic Origin, Population Structure, and Biological Adaptations of the Hui People
Largest-Scale Genomic Resource Reconstructing the Genetic Origin, Population Structure, and Biological Adaptations of the Hui People Open
Historical and archaeological records indicate that the Maritime and Land Silk Roads played a pivotal role in facilitating Trans-Eurasian migrations and cultural exchanges. However, the extent to which population movements or the spread of…
View article: Whole-Genome Sequencing Pilot Study of the Central Asian Genetic Diversity Project Reveals Distinct Genetic Histories, Adaptive Processes, and Introgression Events
Whole-Genome Sequencing Pilot Study of the Central Asian Genetic Diversity Project Reveals Distinct Genetic Histories, Adaptive Processes, and Introgression Events Open
The underrepresentation of Central Asian genomic data has constrained our understanding of their demographic history and hindered advancements in precision medicine and health equity. Despite the region’s rich historical tapestry, characte…
View article: Genomic insights into population stratification, biological adaptation, and archaic introgression at the crossroads of the Himalayas and lowland East Asia
Genomic insights into population stratification, biological adaptation, and archaic introgression at the crossroads of the Himalayas and lowland East Asia Open
The Tibetan-Yi Corridor (TYC) has been a crucial agro-pastoral region in the eastern Himalayas, linking the Qinghai-Tibet Plateau with the lowlands of East Asia and facilitating human migration over millennia. Despite its significance, gen…
View article: Helicobacter pylori Genome Aggregation Database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia
Helicobacter pylori Genome Aggregation Database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia Open
We assembled HPgnomAD, a comprehensive global genome aggregation database of Helicobacter pylori (H. pylori) featuring 7,544 high-quality genomes from 278 populations, along with the first species-wide haplotype reference panel for genotyp…
View article: Bioinformatic insights into five Chinese population substructures inferred from the East Asian-specific AISNP panel
Bioinformatic insights into five Chinese population substructures inferred from the East Asian-specific AISNP panel Open
These panels can differentiate ethnolinguistic Chinese populations into five subgroups based on geographical divisions or linguistic affiliations, achieving a high average accuracy rate in machine learning models. This work not only develo…
View article: <i>Helicobacter pylori</i> genome aggregation database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia
<i>Helicobacter pylori</i> genome aggregation database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia Open
We assembled HPgnomAD, a comprehensive global genome aggregation database of Helicobacter pylori ( H. pylori ) featuring 7,544 high-quality genomes from 278 populations, along with the first species-wide haplotype reference panel for genot…
View article: HSF-DETR: A Special Vehicle Detection Algorithm Based on Hypergraph Spatial Features and Bipolar Attention
HSF-DETR: A Special Vehicle Detection Algorithm Based on Hypergraph Spatial Features and Bipolar Attention Open
Special vehicle detection in intelligent surveillance, emergency rescue, and reconnaissance faces significant challenges in accuracy and robustness under complex environments, necessitating advanced detection algorithms for critical applic…
View article: A Lightweight Multi-Scale Context Detail Network for Efficient Target Detection in Resource-Constrained Environments
A Lightweight Multi-Scale Context Detail Network for Efficient Target Detection in Resource-Constrained Environments Open
Target detection in resource-constrained environments faces multiple challenges such as the use of camouflage, diverse target sizes, and harsh environmental conditions. Moreover, the need for solutions suitable for edge computing environme…
View article: YanHuang Paternal Genomic Resource Suggested A Weakly-Differentiated Multi-Source Admixture Model for the Formation of Han’s Founding Ancestral Lineages
YanHuang Paternal Genomic Resource Suggested A Weakly-Differentiated Multi-Source Admixture Model for the Formation of Han’s Founding Ancestral Lineages Open
The revolution in large-scale human genomics and advancements in statistical methods have profoundly refined our understanding of genetic diversity and structure within human populations. Y-chromosome variations, with their distinct evolut…
View article: Mighty oaks from little acorns: High-quality genomes of underrepresented populations enhance health equity in precision medicine
Mighty oaks from little acorns: High-quality genomes of underrepresented populations enhance health equity in precision medicine Open
View article: A Lightweight Multi-Scale Context Detail Network for Efficient Military Target Detection in Resource-Constrained Environments
A Lightweight Multi-Scale Context Detail Network for Efficient Military Target Detection in Resource-Constrained Environments Open
Military target detection faces multiple challenges, such as the use of camouflage, diverse target sizes, and harsh environmental conditions. Moreover, the need for solutions suitable for edge computing environments, which have limited com…
View article: Patrilineages of ethnolinguistically diverse populations reveal multifactorial influences on Chinese paternal population stratification
Patrilineages of ethnolinguistically diverse populations reveal multifactorial influences on Chinese paternal population stratification Open
Large-scale Y-chromosome genetic resources provide critical insights into human evolutionary history. However, the limited high-density Y-chromosomal data from ethnolinguistically diverse Chinese populations hinder the reconstruction of fi…
View article: Fine-scale biogeographical ancestry inference in Southeast and East Asians via high-efficiency markers and machine learning approaches
Fine-scale biogeographical ancestry inference in Southeast and East Asians via high-efficiency markers and machine learning approaches Open
Biogeographical ancestry inference offers valuable clues for forensic cold cases, but limited information is typically obtained from substructured populations within continental East Asian and Southeast groups. This study presents an integ…
View article: High-quality Population-specific Haplotype-resolved Reference Panel in the Genomic and Pangenomic Eras
High-quality Population-specific Haplotype-resolved Reference Panel in the Genomic and Pangenomic Eras Open
Large-scale international and regional human genomic and pangenomic resources derived from population-scale biobanks and ancient DNA sequences have provided significant insights into human evolution and the genetic determinants of complex …
View article: The large-scale whole-genome sequencing era expedited medical discovery and clinical translation
The large-scale whole-genome sequencing era expedited medical discovery and clinical translation Open
Genomic research has been constrained by insufficient diversity over the past two decades, with over 90 % of studies targeting populations of European ancestry. This imbalance has hampered health equity and precision medicine, resulting i…
View article: YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database
YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database Open
This work successfully integrated Y-chromosome-related basic genomic science with forensic and anthropological translational applications, emphasizing the necessity of comprehensively characterizing Y-chromosome genomic diversity from geno…
View article: Genome-driven Chinese precision medicine: Biobank-scale genomic research as a new paradigm
Genome-driven Chinese precision medicine: Biobank-scale genomic research as a new paradigm Open
Large-scale genomic resources from biobank sequencing projects are crucial for understanding the interplay between environmental and genetic factors in human disease and health traits, as well as for reconstructing human evolutionary histo…
View article: Integrated Genetic and Geographic Ancestry Prediction Using Large-Scale Genomic Data and Machine Learning
Integrated Genetic and Geographic Ancestry Prediction Using Large-Scale Genomic Data and Machine Learning Open
View article: Dissecting the genetic admixture and forensic signatures of ethnolinguistically diverse Chinese populations via a 114-plex NGS InDel panel
Dissecting the genetic admixture and forensic signatures of ethnolinguistically diverse Chinese populations via a 114-plex NGS InDel panel Open
Comprehensive characterizations of genetic diversity and demographic models of ethnolinguistically diverse Chinese populations are essential for elucidating their forensic characteristics and evolutionary past. We developed a 114-plex NGS …
View article: Genomic insights into Neolithic founding paternal lineages around the Qinghai-Xizang Plateau using integrated YanHuang resource
Genomic insights into Neolithic founding paternal lineages around the Qinghai-Xizang Plateau using integrated YanHuang resource Open
View article: Identification of Hub Genes and Immune Infiltration in Coronary Artery Disease: A Risk Prediction Model
Identification of Hub Genes and Immune Infiltration in Coronary Artery Disease: A Risk Prediction Model Open
We demonstrated the molecular mechanism of the hub genes in CAD and provided a valuable tool for predicting the risk of CAD.
View article: Genetic history and biological adaptive landscape of the Tujia people inferred from shared haplotypes and alleles
Genetic history and biological adaptive landscape of the Tujia people inferred from shared haplotypes and alleles Open
The study unveils significant population movements and genetic admixture among the Tujia and other ethno-linguistically diverse East Asian groups, elucidating the differentiated adaptation processes across geographically diverse population…
View article: Forensic investigative genetic genealogy: expanding pedigree tracing and genetic inquiry in the genomic era
Forensic investigative genetic genealogy: expanding pedigree tracing and genetic inquiry in the genomic era Open
Genetic genealogy provides crucial insights into the complex biological relationships within contemporary and ancient human populations by analyzing shared alleles and chromosomal segments that are identical by descent to understand kinshi…
View article: Population genomics of Central Asian peoples unveil ancient Trans-Eurasian genetic admixture and cultural exchanges
Population genomics of Central Asian peoples unveil ancient Trans-Eurasian genetic admixture and cultural exchanges Open
Central Asia, a crucible of prehistoric and historical Trans-Eurasian interactions, has been pivotal in shaping cultural exchanges, population dynamics, and genetic admixture. Recent insights from ancient DNA studies have shed light on the…
View article: Population genetic admixture and evolutionary history in the Shandong Peninsula inferred from integrative modern and ancient genomic resources
Population genetic admixture and evolutionary history in the Shandong Peninsula inferred from integrative modern and ancient genomic resources Open