Guangnian Liu
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View article: Multi-omics analysis of polyamine metabolism implicates NT5E/CD73 in the progression of pancreatic cancer
Multi-omics analysis of polyamine metabolism implicates NT5E/CD73 in the progression of pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) exhibits profound metabolic reprogramming, with polyamine metabolism emerging as a key driver of tumor progression and immune evasion. However, its comprehensive role and clinical significance in PDA…
View article: Current status and future prospects of cancer-derived immunoglobulins in pancreatic cancer
Current status and future prospects of cancer-derived immunoglobulins in pancreatic cancer Open
Immunoglobulin (Ig) is an important part of the immune system, which is mainly produced by B cells to recognize and kill pathogens. In recent years, the concept of cancer-derived immunoglobulin (cIg) has been proposed. cIg is a special for…
View article: Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming
Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming Open
While studies of various carcinomas have reported aberrant metal metabolism, much remains unknown regarding their spatial accumulation and regulatory impacts in tumors. Here, elevated copper levels are detected in breast cancer tumors from…
View article: Prognostic implications and characterization of tumor-associated tertiary lymphoid structures genes in pancreatic cancer
Prognostic implications and characterization of tumor-associated tertiary lymphoid structures genes in pancreatic cancer Open
This study elucidated the expression profile of TA-TLS genes in PDAC, constructed a TLS gene-based scoring system, and developed a related risk model. We also explored the functions and potential antitumor mechanisms of key genes, providin…
View article: Cancer associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution
Cancer associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution Open
Metabolic reprogramming provides tumors with an energy source and biofuel to support their survival in the malignant microenvironment. Extensive research into the intrinsic oncogenic mechanisms of the tumor microenvironment (TME) has estab…
View article: Hypoxia-induced epigenetic regulation of miR-485-3p promotes stemness and chemoresistance in pancreatic ductal adenocarcinoma via SLC7A11-mediated ferroptosis
Hypoxia-induced epigenetic regulation of miR-485-3p promotes stemness and chemoresistance in pancreatic ductal adenocarcinoma via SLC7A11-mediated ferroptosis Open
The mechanism of hypoxia in chemoresistance of pancreatic ductal adenocarcinoma (PDAC) remains elusive. In this study, we reveled essential role of miR-485-3p in PDAC, particularly its impact on cancer stemness and gemcitabine resistance u…
View article: Prophylactic Intra-Peritoneal Drainage After Pancreatic Resection: An Updated Meta-Analysis
Prophylactic Intra-Peritoneal Drainage After Pancreatic Resection: An Updated Meta-Analysis Open
Introduction Prophylactic intra-peritoneal drainage has been considered to be an effective measure to reduce postoperative complications after pancreatectomy. However, routinely placed drainage during abdominal surgery may be unnecessary o…