Guojun Qian
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View article: Cardiorespiratory fitness-associated gene signature for prognosis in hepatocellular Carcinoma: Computational prediction and in vivo validation
Cardiorespiratory fitness-associated gene signature for prognosis in hepatocellular Carcinoma: Computational prediction and in vivo validation Open
Cardiorespiratory fitness (CRF) plays a crucial role in cancer progression and prognosis, yet its molecular mechanisms remain poorly understood. This study aims to develop a prognostic model based on CRF-related genes in hepatocellular car…
View article: NCOA4-Mediated Ferritinophagy Induces Ferroptosis and Enriches Ferritin-Containing EVs via Ferritin Phase Separation to Promote Mechanical Ventilation-Induced Pulmonary Fibrosis
NCOA4-Mediated Ferritinophagy Induces Ferroptosis and Enriches Ferritin-Containing EVs via Ferritin Phase Separation to Promote Mechanical Ventilation-Induced Pulmonary Fibrosis Open
MV induces ANG II/AGTR1-mediated ferritinophagy and ferroptosis in AECs. NCOA4-driven ferritin phase separation promotes ferritinophagy under mechanical stress. Ferritin-containing EVs from damaged AECs activate fibroblasts, exacerbating M…
View article: Risk factor analysis for cardiac abnormalities in patients with idiopathic scoliosis
Risk factor analysis for cardiac abnormalities in patients with idiopathic scoliosis Open
The proportion of cardiac abnormalities in patients with idiopathic scoliosis(IS) who required surgery is relatively high. However, the specific cause and underlying risk factors remain poorly elucidated. A retrospective study. To investig…
View article: PGC-1α mediates migrasome secretion accelerating macrophage–myofibroblast transition and contributing to sepsis-associated pulmonary fibrosis
PGC-1α mediates migrasome secretion accelerating macrophage–myofibroblast transition and contributing to sepsis-associated pulmonary fibrosis Open
Sepsis-associated pulmonary fibrosis (SAPF) is a critical pathological stage in the progression of sepsis-induced acute respiratory distress syndrome. While the aggregation and activation of lung fibroblasts are central to the initiation o…
View article: Prevalence of scoliosis and congenital heart disease based on school screening in Jinghong City, Yunnan Province
Prevalence of scoliosis and congenital heart disease based on school screening in Jinghong City, Yunnan Province Open
Objective To investigate the prevalence of scoliosis and congenital heart disease (CHD) in the same area and to explore the relationship between them according to a joint school screening. Methods All students aged 6–15 years in 20 schools…
View article: Incidence and risk factors of cardiac abnormalities in patients with idiopathic scoliosis vs congenital scoliosis
Incidence and risk factors of cardiac abnormalities in patients with idiopathic scoliosis vs congenital scoliosis Open
View article: Enhancing Code LLMs with Reinforcement Learning in Code Generation: A Survey
Enhancing Code LLMs with Reinforcement Learning in Code Generation: A Survey Open
With the rapid evolution of large language models (LLM), reinforcement learning (RL) has emerged as a pivotal technique for code generation and optimization in various domains. This paper presents a systematic survey of the application of …
View article: Association of diabetes mellitus with long-term prognosis after ablation therapy for patients with hepatocellular carcinoma: A single-center cohort study
Association of diabetes mellitus with long-term prognosis after ablation therapy for patients with hepatocellular carcinoma: A single-center cohort study Open
Background: This study investigated the clinical efficacy and prognostic factors of ablative treatment in hepatocellular carcinoma (HCC) patients with and without diabetes mellitus (DM). Methods: Retrospective data were collected from HCC …
View article: Prognostic significance of postoperative serological incomplete conversion of AFP and PIVKA-II after hepatic resection for hepatocellular carcinoma: a multicenter analysis of 1755 patients
Prognostic significance of postoperative serological incomplete conversion of AFP and PIVKA-II after hepatic resection for hepatocellular carcinoma: a multicenter analysis of 1755 patients Open
Background The value of serum biomarkers, particularly alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II), gains increasing attention in prognostic evaluation and recurrence monitoring for patients…
View article: Efficacy of microwave ablation with parallel acupuncture guided by ultrasound in treating single hepatocellular carcinoma in high-risk areas: A retrospective analysis of 155 patients
Efficacy of microwave ablation with parallel acupuncture guided by ultrasound in treating single hepatocellular carcinoma in high-risk areas: A retrospective analysis of 155 patients Open
Objective: To investigate the safety and short- and long-term efficacy of ultrasound-guided microwave ablation (MWA) with parallel acupuncture for treating single hepatocellular carcinoma (HCC) in high-risk areas. Methods: Retrospective an…
View article: Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trial
Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trial Open
Many patients who underwent hepatic percutaneous microwave ablation (MWA) reported experiencing pain during the procedure. This study utilized a well-designed multicentral, randomized, and placebo-controlled format to investigate the effec…
View article: Reviewer's Recognition
Reviewer's Recognition Open
View article: Therapeutic Potential of Glutaminase Inhibitor in Idiopathic Pulmonary Fibrosis Through Nufip1-Dependent Ribophagy
Therapeutic Potential of Glutaminase Inhibitor in Idiopathic Pulmonary Fibrosis Through Nufip1-Dependent Ribophagy Open
View article: Editorial: Resolution and regeneration of inflammation in lung and brain disorders
Editorial: Resolution and regeneration of inflammation in lung and brain disorders Open
Editorial on the Research Topic: 13Our understanding of inflammation continues to evolve, revealing its intricate double-edged 16 nature in human health. Once seen as a simple reaction, inflammation is now recognized as a 17 complex multi-…
View article: A hub gene signature as a therapeutic target and biomarker for sepsis and geriatric sepsis-induced ARDS concomitant with COVID-19 infection
A hub gene signature as a therapeutic target and biomarker for sepsis and geriatric sepsis-induced ARDS concomitant with COVID-19 infection Open
Background COVID-19 and sepsis represent formidable public health challenges, characterized by incompletely elucidated molecular mechanisms. Elucidating the interplay between COVID-19 and sepsis, particularly in geriatric patients sufferin…
View article: B-cell-derived IL-10 promotes allergic sensitization in asthma regulated by Bcl-3
B-cell-derived IL-10 promotes allergic sensitization in asthma regulated by Bcl-3 Open
View article: B cell-derived IL-10 promotes the resolution of lipopolysaccharide-induced acute lung injury
B cell-derived IL-10 promotes the resolution of lipopolysaccharide-induced acute lung injury Open
Inflammation resolution is critical for acute lung injury (ALI) recovery. Interleukin (IL)-10 is a potent anti-inflammatory factor. However, its role in ALI resolution remains unclear. We investigated the effects of IL-10 during the ALI re…
View article: Integrative bioinformatics and validation studies reveal KDM6B and its associated molecules as crucial modulators in Idiopathic Pulmonary Fibrosis
Integrative bioinformatics and validation studies reveal KDM6B and its associated molecules as crucial modulators in Idiopathic Pulmonary Fibrosis Open
Background Idiopathic Pulmonary Fibrosis (IPF) can be described as a debilitating lung disease that is characterized by the complex interactions between various immune cell types and signaling pathways. Chromatin-modifying enzymes are sign…
View article: Nomograms predict survival benefits of radical prostatectomy and chemotherapy for prostate cancer with bone metastases: A SEER‐based study
Nomograms predict survival benefits of radical prostatectomy and chemotherapy for prostate cancer with bone metastases: A SEER‐based study Open
Purpose This study aimed to identify independent prognosis-associated factors of bone-metastatic prostate cancer. The nomograms were further developed to obtain indicators for the prognostic evaluation. Methods A total of 7315 bone-metasta…
View article: Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma
Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma Open
Background The coronavirus disease (COVID-19) pandemic has posed a significant challenge for global health systems. Increasing evidence shows that asthma phenotypes and comorbidities are major risk factors for COVID-19 symptom severity. Ho…
View article: Comparison of percutaneous microwave ablation with radiofrequency ablation for hepatocellular carcinoma adjacent to major vessels
Comparison of percutaneous microwave ablation with radiofrequency ablation for hepatocellular carcinoma adjacent to major vessels Open
Purpose: To compare the therapeutic efficacy and safety of percutaneous microwave ablation (MWA) with those of percutaneous radiofrequency ablation (RFA) for the treatment of hepatocellular carcinoma (HCC) adjacent to major vessels. Method…
View article: A host lipase prevents lipopolysaccharide-induced foam cell formation
A host lipase prevents lipopolysaccharide-induced foam cell formation Open
View article: Serum RelB is correlated with renal fibrosis and predicts chronic kidney disease progression
Serum RelB is correlated with renal fibrosis and predicts chronic kidney disease progression Open
Dear Editor, Chronic kidney disease (CKD) with characteristics of progressive deterioration of renal function is regarded as one major public health problem around the world. The patients are often diagnosed at advanced stages with most ki…
View article: Long-term Effects of Repeat Hepatectomy vs Percutaneous Radiofrequency Ablation Among Patients With Recurrent Hepatocellular Carcinoma
Long-term Effects of Repeat Hepatectomy vs Percutaneous Radiofrequency Ablation Among Patients With Recurrent Hepatocellular Carcinoma Open
ClinicalTrials.gov identifier: NCT00822562.
View article: Antiviral therapy improves outcomes after radiofrequency ablation for HBV-related hepatocellular carcinoma: A propensity score matching analysis
Antiviral therapy improves outcomes after radiofrequency ablation for HBV-related hepatocellular carcinoma: A propensity score matching analysis Open
Background: We intended to explore hepatitis B virus (HBV) reactivation after percutaneous radiofrequency ablation (PRFA) for HBV-related hepatocellular carcinoma (HCC) and the impact of antiviral therapy (AVT) on post-PRFA outcomes. Metho…
View article: LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma
LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma Open
Allergic asthma is a chronic inflammatory disease primarily mediated by Th2 immune mechanisms. Numerous studies have suggested that early life exposure to lipopolysaccharide (LPS) is negatively associated with allergic asthma. One proposed…
View article: Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury
Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury Open
Pulmonary infection is the most common risk factor for acute lung injury (ALI). Innate immune responses induced by Microbe-Associated Molecular Pattern (MAMP) molecules are essential for lung defense but can lead to tissue injury. Little i…
View article: Microwave ablation is as effective as radiofrequency ablation for very-early-stage hepatocellular carcinoma
Microwave ablation is as effective as radiofrequency ablation for very-early-stage hepatocellular carcinoma Open
View article: Multidisciplinary management of hepatocellular carcinoma with portal vein tumor thrombus - Eastern Hepatobiliary Surgical Hospital consensus statement
Multidisciplinary management of hepatocellular carcinoma with portal vein tumor thrombus - Eastern Hepatobiliary Surgical Hospital consensus statement Open
Hepatocellular carcinoma (HCC) complicated by portal vein tumor thrombus (PVTT) is associated with poor prognosis, early recurrence of HCC, and limited treatment options. Current guidelines do not have standardized diagnostic and treatment…