Guangyan Wei
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View article: A novel cell-permeable LOXL2 inhibitor PAT-1251 potently suppresses biliary liver fibrosis via collagen crosslinking-dependent and -independent mechanisms
A novel cell-permeable LOXL2 inhibitor PAT-1251 potently suppresses biliary liver fibrosis via collagen crosslinking-dependent and -independent mechanisms Open
Background: LOXL2 promotes fibrosis through extracellular collagen crosslinking and intracellular signaling mechanisms. Here, we studied the mode of action of a novel potent, cell-permeable LOXL2 inhibitor PAT-1251 on hepatic fibrosis. Met…
View article: Transarterial intervention therapy plus systemic therapy for unresectable hepatocellular carcinoma: A systematic review and meta-analysis
Transarterial intervention therapy plus systemic therapy for unresectable hepatocellular carcinoma: A systematic review and meta-analysis Open
Recently, the combination of transarterial intervention therapy (transcatheter arterial chemoembolization [TACE] or hepatic arterial infusion chemotherapy [HAIC]) and systemic therapy for unresectable hepatocellular carcinoma (HCC) has yie…
View article: Effect of compound kushen injection on immune function in patients with colorectal cancer: a systematic review and meta-analysis
Effect of compound kushen injection on immune function in patients with colorectal cancer: a systematic review and meta-analysis Open
Background Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. Chemotherapy and radiotherapy remain cornerstone treatments; however, they often lead to significant immune suppression and an increased risk of infec…
View article: Telomere Length as Both Cause and Consequence in Type 1 Diabetes: Evidence from Bidirectional Mendelian Randomization
Telomere Length as Both Cause and Consequence in Type 1 Diabetes: Evidence from Bidirectional Mendelian Randomization Open
Background/Objectives: Diabetes is the most prevalent metabolic disease globally, characterized by dysregulated glucose control and accompanied by multiple refractory complications. As a critical marker of cellular homeostasis, telomere le…
View article: CA19-9-related macrophage polarization drives poor prognosis in HCC after immune checkpoint inhibitor treatment
CA19-9-related macrophage polarization drives poor prognosis in HCC after immune checkpoint inhibitor treatment Open
Background Elevated levels of carbohydrate antigen 19-9 (CA19-9) levels are known to worsen outcomes in various tumors by influencing immune responses. However, the role of CA19-9 in immunotherapy for hepatocellular carcinoma (HCC) remains…
View article: Transposon-based oncogene integration in Abcb4(Mdr2)-/- mice recapitulates high susceptibility to cholangiocarcinoma in primary sclerosing cholangitis
Transposon-based oncogene integration in Abcb4(Mdr2)-/- mice recapitulates high susceptibility to cholangiocarcinoma in primary sclerosing cholangitis Open
Animal models for primary sclerosing cholangitis (PSC)-related cholangiocarcinoma (PSC-CCA) are lacking. Thus, we have developed and characterized a new mouse model of PSC-CCA, termed SB CCA.Mdr2-/-, which features reliable tumor induction…
View article: Therapeutic targeting of PLK1 in <i>TERT</i> promoter‐mutant hepatocellular carcinoma
Therapeutic targeting of PLK1 in <i>TERT</i> promoter‐mutant hepatocellular carcinoma Open
Background Hotspot mutations in the promoter of telomerase reverse transcriptase ( TERT ) gene are the most common genetic variants in hepatocellular carcinoma (HCC) and associated with poor prognosis of the disease. However, no drug was c…
View article: Anti-PD-1 antibody in combination with radiotherapy as first-line therapy for unresectable intrahepatic cholangiocarcinoma
Anti-PD-1 antibody in combination with radiotherapy as first-line therapy for unresectable intrahepatic cholangiocarcinoma Open
Background Unresectable intrahepatic cholangiocarcinoma (iCCA) has a poor prognosis despite treatment with standard combination chemotherapy. We aimed to evaluate the efficacy and safety of radiotherapy in combination with an anti-PD-1 ant…
View article: Spermine Synthase Engages in Macrophages M2 polarization to Sabotage Antitumor Immunity in Hepatocellular Carcinoma
Spermine Synthase Engages in Macrophages M2 polarization to Sabotage Antitumor Immunity in Hepatocellular Carcinoma Open
Disturbances in tumor cell metabolism reshape the tumor microenvironment (TME) and impair antitumor immunity, but the implicit mechanisms remain elusive. Here, we found that spermine synthase (SMS) was significantly upregulated in tumor ce…
View article: The progression of hepatocyte pyroptosis exacerbates radiation-induced liver disease via the gasdermin D/signal transducer and activator of transcription 5a/CXCL1 axis
The progression of hepatocyte pyroptosis exacerbates radiation-induced liver disease via the gasdermin D/signal transducer and activator of transcription 5a/CXCL1 axis Open
Radiation-induced liver disease (RILD) severely impairs the outcome of patients exposed to irradiation (IR); however, the underlying mechanism is largely unknown. The N-terminus of gasdermin D (GSDMD-N) is mainly involved in driving the pr…
View article: Nab-paclitaxel and gemcitabine plus camrelizumab and radiotherapy versus nab-paclitaxel and gemcitabine alone for locally advanced pancreatic adenocarcinoma: a prospective cohort study
Nab-paclitaxel and gemcitabine plus camrelizumab and radiotherapy versus nab-paclitaxel and gemcitabine alone for locally advanced pancreatic adenocarcinoma: a prospective cohort study Open
Treatment options specifically for patients with locally advanced pancreatic adenocarcinoma (LAPC) are scare and chemotherapy alone delivers limited efficacy. Immunotherapy and radiotherapy are potential effective treatments for LAPC, and …
View article: Automated whole slide image analysis for a translational quantification of liver fibrosis
Automated whole slide image analysis for a translational quantification of liver fibrosis Open
Current literature highlights the need for precise histological quantitative assessment of fibrosis which cannot be achieved by conventional scoring systems, inherent to their discontinuous values and reader-dependent variability. Here we …
View article: Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells
Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells Open
Activation of resident macrophages (Mϕ) and hepatic stellate cells is a key event in chronic liver injury. Mice with heme oxygenase-1 (HO-1; Hmox1)-deficient Mϕ (LysM-Cre:Hmox1 flfl ) exhibit increased inflammation, periportal ductular rea…
View article: Automated Whole Slide Image Analysis for a Translational Quantification of Liver Fibrosis
Automated Whole Slide Image Analysis for a Translational Quantification of Liver Fibrosis Open
Current literature highlights the need for precise histological quantitative assessment of fibrosis which cannot be achieved by conventional scoring systems, inherent to their discontinuous values and reader-dependent variability. Here we …
View article: Dynamic Simulation and Experimental Study of Electric Vehicle Motor-Gear System Based on State Space Method
Dynamic Simulation and Experimental Study of Electric Vehicle Motor-Gear System Based on State Space Method Open
In the research on electric vehicle transmission vibration characteristics, the dynamic model involving a multistage gear system is still rare, especially the influences of driving motor excitation and load excitation which are not conside…
View article: [ELF4 promotes proliferation and inhibits apoptosis of human insulinoma cells by activating Akt signaling].
[ELF4 promotes proliferation and inhibits apoptosis of human insulinoma cells by activating Akt signaling]. Open
ELF4 overexpression enhances the proliferation and suppresses apoptosis of insulinomas cells by activating Akt signaling.
View article: A novel non‐bile acid FXR agonist EDP‐305 potently suppresses liver injury and fibrosis without worsening of ductular reaction
A novel non‐bile acid FXR agonist EDP‐305 potently suppresses liver injury and fibrosis without worsening of ductular reaction Open
Background EDP‐305 is a novel and potent farnesoid X receptor (FXR) agonist, with no/minimal cross‐reactivity to TGR5 or other nuclear receptors. Herein we report therapeutic efficacy of EDP‐305, in direct comparison with the first‐in‐clas…
View article: FGF14 Functions as a Tumor Suppressor through Inhibiting PI3K/AKT/mTOR Pathway in Colorectal Cancer
FGF14 Functions as a Tumor Suppressor through Inhibiting PI3K/AKT/mTOR Pathway in Colorectal Cancer Open
We identified that Fibroblast Growth Factor 14 (FGF14) was preferentially methylated in colorectal cancer (CRC). In this study, we aimed to investigate the epigenetic regulation, biological function and molecular mechanism of FGF14 in CRC.…
View article: Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer
Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer Open
Progressive fibrosis, functional liver failure, and cancer are the central liver-related outcomes of nonalcoholic steatohepatitis (NASH) but notoriously difficult to achieve in mouse models. We performed a direct, quantitative comparison o…
View article: IDDF2019-ABS-0102 Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction and rapid progression to cirrhosis, cancer
IDDF2019-ABS-0102 Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction and rapid progression to cirrhosis, cancer Open
Background Progressive fibrosis, functional liver failure and liver cancer are the central liver-related outcomes of nonalcoholic steatohepatitis (NASH). However, these pathologies are notoriously difficult to achieve in mouse models. We, …
View article: IDDF2019-ABS-0113 FGF14 is a functional tumor suppressor through inhibiting PI3K/AKT/mTOR pathway in colorectal cancer
IDDF2019-ABS-0113 FGF14 is a functional tumor suppressor through inhibiting PI3K/AKT/mTOR pathway in colorectal cancer Open
Background Colorectal cancer (CRC) is one of the most common malignancies worldwide. Emerging evidence indicates that promoter methylation of genes associated with gene silencing, plays an important role in the development and progression …
View article: IDDF2019-ABS-0128 Functional mechanism of vascular endothelial growth factor in promoting the growth of intrahepatic cholangiocarcinoma
IDDF2019-ABS-0128 Functional mechanism of vascular endothelial growth factor in promoting the growth of intrahepatic cholangiocarcinoma Open
Background To investigate the role of vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) on cell growth of intrahepatic cholangiocarcinoma (ICC). Methods Western blotting was performed to detect the expression of VEGF in…
View article: Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction and rapid progression to cirrhosis, cancer
Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction and rapid progression to cirrhosis, cancer Open
supplementary figures and tables
View article: Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction and rapid progression to cirrhosis, cancer
Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction and rapid progression to cirrhosis, cancer Open
supplementary figures and tables