Guangyao Mao
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View article: Correction: Icariside II inhibits gastric cancer progression by suppressing the Wnt/β-catenin signaling pathway
Correction: Icariside II inhibits gastric cancer progression by suppressing the Wnt/β-catenin signaling pathway Open
View article: High-resolution spatial transcriptomics in fixed tissue using a cost-effective PCL-seq workflow
High-resolution spatial transcriptomics in fixed tissue using a cost-effective PCL-seq workflow Open
The spatial heterogeneity of gene expression has driven the development of diverse spatial transcriptomics technologies. Here, we present photocleavage and ligation sequencing (PCL-seq), a spatial indexing method utilizing a light-controll…
View article: Low expression of SGCA promotes lung squamous cell carcinoma malignant progression
Low expression of SGCA promotes lung squamous cell carcinoma malignant progression Open
View article: Digital reconstruction of full embryos during early mouse organogenesis
Digital reconstruction of full embryos during early mouse organogenesis Open
Early organogenesis is a crucial stage in embryonic development, characterized by extensive cell fate specification to initiate organ formation but also by a high susceptibility to developmental defects. Here, we profiled 285 serial sectio…
View article: Clusterin activates the heat shock response via the PI3K/Akt pathway to protect cardiomyocytes from high-temperature-induced apoptosis
Clusterin activates the heat shock response via the PI3K/Akt pathway to protect cardiomyocytes from high-temperature-induced apoptosis Open
High temperature (HT) is a common symptom of infectious myocarditis. This study investigates the effects of HT on the heat shock response (HSR) and apoptosis in cardiomyocytes, with the aim of providing insights into potential treatment st…
View article: Photo-Thermally Controllable Tumor Metabolic Modulation to Assist T Cell Activation for Boosting Immunotherapy
Photo-Thermally Controllable Tumor Metabolic Modulation to Assist T Cell Activation for Boosting Immunotherapy Open
In response to the changes in immune microenvironment caused by tumor metabolism, a photo-thermal precision-controlled drug delivery platform was successfully developed. This platform reshapes the tumor immunosuppressive microenvironment, …
View article: SpatialQC: automated quality control for spatial transcriptome data
SpatialQC: automated quality control for spatial transcriptome data Open
Summary The advent of spatial transcriptomics has revolutionized our understanding of the spatial heterogeneity in tissues, providing unprecedented insights into the cellular and molecular mechanisms underlying biological processes. Althou…
View article: Low expression of SGCA promotes LUSC malignant progression
Low expression of SGCA promotes LUSC malignant progression Open
Objectives As a common pathological type of non-small-cell lung cancer (NSCLC), Lung squamous cell carcinoma (LUSC) with high mortality lacks a desired diagnostic indicator and therapeutic target. This study is aimed to reveal low expressi…
View article: Serum CD40L, ST2, IL-6, and CRP serving as biomarkers for acute coronary syndrome
Serum CD40L, ST2, IL-6, and CRP serving as biomarkers for acute coronary syndrome Open
To analyze the diagnostic value of CD40 ligand (CD40L), soluble growth stimulating expression gene 2 protein (ST2), interleukin-6 (IL-6), and C-reactive protein (CRP) are used in patients with acute coronary syndrome (ACS). Serum samples w…