Guangyuan Zhang
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View article: Aspiration pneumonia in diabetic ketoacidosis: a decade-long analysis of occurrence , associated risk factors and clinical outcomes in 530,700 US hospitalizations
Aspiration pneumonia in diabetic ketoacidosis: a decade-long analysis of occurrence , associated risk factors and clinical outcomes in 530,700 US hospitalizations Open
Background Aspiration pneumonia (AP) is a serious clinical condition among patients with diabetic ketoacidosis (DKA). This study aimed to determine the occurrence and associated risk factors for AP among patients hospitalized with DKA. Met…
View article: Burden and forecast of colorectal cancer in the selected East Asian countries (1990–2036): a systematic analysis based on the global burden of disease study 2021
Burden and forecast of colorectal cancer in the selected East Asian countries (1990–2036): a systematic analysis based on the global burden of disease study 2021 Open
This study provides novel, region‑specific evidence that demographic aging is the principal driver of rising CRC burden in East Asia. The findings highlight an urgent need for tailored prevention, screening and resource planning focused on…
View article: Association between low-dose aspirin use and kidney stone disease in middle-aged and older Americans: Data from the national health and nutrition examination survey 2011–2018
Association between low-dose aspirin use and kidney stone disease in middle-aged and older Americans: Data from the national health and nutrition examination survey 2011–2018 Open
View article: Prospective Phase 2 Clinical Trial of Carbon Ion Radiation Therapy Combined With Chemotherapy for Locally Advanced Pancreatic Carcinoma
Prospective Phase 2 Clinical Trial of Carbon Ion Radiation Therapy Combined With Chemotherapy for Locally Advanced Pancreatic Carcinoma Open
View article: Remote ischemia precondition protects against renal IRI through apoptosis associated vesicles carrying MIF protein via modulating DUSP6/JNK signaling axis
Remote ischemia precondition protects against renal IRI through apoptosis associated vesicles carrying MIF protein via modulating DUSP6/JNK signaling axis Open
View article: Xuebijing injection alleviates septic acute kidney injury by modulating inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress
Xuebijing injection alleviates septic acute kidney injury by modulating inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress Open
This study indicates that XBJ injection is a promising drug for the treatment of septic AKI.
View article: Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury
Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury Open
View article: Correction: Zhang et al. Interactions of Self-Assembled Bletilla Striata Polysaccharide Nanoparticles with Bovine Serum Albumin and Biodistribution of Its Docetaxel-Loaded Nanoparticles. Pharmaceutics 2019, 11, 43
Correction: Zhang et al. Interactions of Self-Assembled Bletilla Striata Polysaccharide Nanoparticles with Bovine Serum Albumin and Biodistribution of Its Docetaxel-Loaded Nanoparticles. Pharmaceutics 2019, 11, 43 Open
In the original publication [...]
View article: Enhanced Therapeutic Effects of Hypoxia-Preconditioned Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Renal Ischemic Injury
Enhanced Therapeutic Effects of Hypoxia-Preconditioned Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Renal Ischemic Injury Open
Background Extracellular vesicles (EVs) secreted by mesenchymal stromal cells (MSCs) provide significant protection against renal ischemia-reperfusion injury (IRI). Hypoxia is considered an important method for enhancing the tissue repair …
View article: DRD4 alleviates acute kidney injury by suppressing ISG15/NOX4 axis-associated oxidative stress
DRD4 alleviates acute kidney injury by suppressing ISG15/NOX4 axis-associated oxidative stress Open
Acute kidney injury (AKI) is a life-threatening health condition associated with increasing morbidity and mortality. Despite extensive research on the mechanisms underlying AKI, effective clinical tools for prediction and treatment remain …
View article: IL20RB Is a Prognostically Significant Gene and a Potential Biomarker in Papillary Renal Cell Carcinoma
IL20RB Is a Prognostically Significant Gene and a Potential Biomarker in Papillary Renal Cell Carcinoma Open
View article: Local Tumor Progression Predictive Model Based on MRI for Colorectal Cancer Liver Metastases after Radiofrequency Ablation
Local Tumor Progression Predictive Model Based on MRI for Colorectal Cancer Liver Metastases after Radiofrequency Ablation Open
The semi-quantitative MRIAS 1MO criteria, used for post-RFA MRI appearance analysis, exhibited strong measurement reliability. Prediction models established based on overall MRIAS 1MO score (MRIS) and lesion diameter had good predictive pe…
View article: Clinical study of Tuina combined with functional training to improve the clinical symptoms and balance function in patients with meniscus injury
Clinical study of Tuina combined with functional training to improve the clinical symptoms and balance function in patients with meniscus injury Open
Objective To observe the effect of Tuina (Chinese therapeutic massage) combined with functional training in improving clinical symptoms and balance function in patients with meniscus injury. Methods A total of 93 patients with grade I-II m…
View article: Biological and clinical significance of radiomics features obtained from magnetic resonance imaging preceding pre-carbon ion radiotherapy in prostate cancer based on radiometabolomics
Biological and clinical significance of radiomics features obtained from magnetic resonance imaging preceding pre-carbon ion radiotherapy in prostate cancer based on radiometabolomics Open
Introduction We aimed to investigate the feasibility of metabolomics to explain the underlying biological implications of radiomics features obtained from magnetic resonance imaging (MRI) preceding carbon ion radiotherapy (CIRT) in patient…
View article: Definitive carbon ion re-irradiation with pencil beam scanning in the treatment of unresectable locally recurrent rectal cancer
Definitive carbon ion re-irradiation with pencil beam scanning in the treatment of unresectable locally recurrent rectal cancer Open
This study aimed to evaluate the oncological outcomes and safety of carbon ion re-irradiation with pencil beam scanning (PBS) delivery technique for previously irradiated and unresectable locally recurrent rectal cancer (LRRC). Between Jun…
View article: Evaluating the Performance of different large language models on health consultation and patient education in urolithiasis
Evaluating the Performance of different large language models on health consultation and patient education in urolithiasis Open
Objectives To evaluate the effectiveness of four large language models (LLMs) (Claude, Bard, ChatGPT4, and New Bing) that have large user bases and significant social attention, in the context of medical consultation and patient education …
View article: Development and validation of a prognostic model incorporating tumor thrombus grading for nonmetastatic clear cell renal cell carcinoma with tumor thrombus: A multicohort study
Development and validation of a prognostic model incorporating tumor thrombus grading for nonmetastatic clear cell renal cell carcinoma with tumor thrombus: A multicohort study Open
There is significant variability with respect to the prognosis of nonmetastatic clear cell renal cell carcinoma (ccRCC) patients with venous tumor thrombus (VTT). By applying multiregion whole‐exome sequencing on normal‐tumor‐thrombus‐meta…
View article: Prognostic Significance of Grade Discrepancy Between Primary Tumor and Venous Thrombus in Nonmetastatic Clear-cell Renal Cell Carcinoma: Analysis of the REMEMBER Registry and Implications for Adjuvant Therapy
Prognostic Significance of Grade Discrepancy Between Primary Tumor and Venous Thrombus in Nonmetastatic Clear-cell Renal Cell Carcinoma: Analysis of the REMEMBER Registry and Implications for Adjuvant Therapy Open
View article: IL-17C neutralization protects the kidney against acute injury and chronic injury
IL-17C neutralization protects the kidney against acute injury and chronic injury Open
The National Natural Science Foundation of China (81770741, 81700601 and 81870504).
View article: Predictive value of single-nucleotide polymorphism signature for nephrolithiasis recurrence: a 5-year prospective study
Predictive value of single-nucleotide polymorphism signature for nephrolithiasis recurrence: a 5-year prospective study Open
Background Genetic variations are linked to kidney stone formation. However, the association of single nucleotide polymorphism (SNPs) and stone recurrence has not been well studied. This study aims to identify genetic variants associated w…
View article: YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6
YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6 Open
Background Tumor-associated macrophages are mainly polarized into the M2 phenotype, remodeling the tumor microenvironment and promoting tumor progression by secreting various cytokines. Methods Tissue microarray consisting of prostate canc…
View article: Fibrinogen Is Associated with Prognosis of Critically Ill Patients with Sepsis: A Study Based on Cox Regression and Propensity Score Matching
Fibrinogen Is Associated with Prognosis of Critically Ill Patients with Sepsis: A Study Based on Cox Regression and Propensity Score Matching Open
Introduction. Sepsis is a common syndrome in critically ill patients. Fibrinogen was reported to be associated with the prognosis of sepsis patients. Materials and Methods. Data was acquired from Multiparameter Intelligent Monitoring in In…
View article: Acetate attenuates hyperoxaluria-induced kidney injury by inhibiting macrophage infiltration via the miR-493-3p/MIF axis
Acetate attenuates hyperoxaluria-induced kidney injury by inhibiting macrophage infiltration via the miR-493-3p/MIF axis Open
View article: Heat shock protein: a double-edged sword linking innate immunity and hepatitis B virus infection
Heat shock protein: a double-edged sword linking innate immunity and hepatitis B virus infection Open
Heat shock proteins (HSPs), which have a variety of functions, are one of the stress protein families. In recent years, They have been reported to play a dual role in hepatitis B virus (HBV) which as persistent infection which is associate…
View article: Bariatric surgery reduces sleep apnea in obese patients with obstructive sleep apnea by increasing pharyngeal cross-sectional area during the early postoperative period
Bariatric surgery reduces sleep apnea in obese patients with obstructive sleep apnea by increasing pharyngeal cross-sectional area during the early postoperative period Open
Objective Bariatric surgery (BS) is considered one of the most effective treatments for obese individuals with Obstructive Sleep Apnea (OSA). However, otolaryngologists have raised concerns about the structural alterations caused by BS on …
View article: Impact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor
Impact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor Open
Transcatheter arterial chemoembolization (TACE) is usually considered more efficacious in the local treatment of parenchyma-sparing hepatocellular carcinoma (HCC). At present, embolic agents commonly used in TACE, include DC pellets, Hepas…
View article: Platelet-derived extracellular vesicles aggravate septic acute kidney injury via delivering ARF6
Platelet-derived extracellular vesicles aggravate septic acute kidney injury via delivering ARF6 Open
Circulating plasma extracellular vesicles (EVs) mostly originate from platelets and may promote organ dysfunction in sepsis. However, the role of platelet-derived EVs in sepsis-induced acute kidney injury (AKI) remains poorly understood. T…
View article: Desmethoxycurcumin aids IFNα’s anti-HBV activity by antagonising CRYAB reduction and stabilising IFNAR1 protein
Desmethoxycurcumin aids IFNα’s anti-HBV activity by antagonising CRYAB reduction and stabilising IFNAR1 protein Open
The eradication of chronic hepatitis B (CHB) caused by hepatitis B virus (HBV) infection is a crucial goal in clinical practice. Enhancing the anti-HBV activity of interferon type I (IFNI) is a key strategy for achieving a functional cure …
View article: CASP4 and CASP8 as newly defined autophagy-pyroptosis-related genes associated with clinical and prognostic features of renal cell carcinoma
CASP4 and CASP8 as newly defined autophagy-pyroptosis-related genes associated with clinical and prognostic features of renal cell carcinoma Open
Objective: The rapid discoveries of autophagy and pyroptosis have opened new avenues for treating renal cell carcinoma (RCC). The objective was to identify potential autophagy-pyroptosis-related drug targets and plausible prognostic biomar…
View article: Fibrinogen and antithrombin III are associated with in-hospital mortality among critically ill patients with acute kidney injury
Fibrinogen and antithrombin III are associated with in-hospital mortality among critically ill patients with acute kidney injury Open
Low fibrinogen is an independent predictor of in-hospital mortality in critically ill patients with AKI. Low ATIII activity is also likely to impact the risk of in-hospital death.