Guangzu Zhao
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View article: Co-administration of a synthetic saccharide conjugate vaccine with BCG provides synergistic protection against murine tuberculosis
Co-administration of a synthetic saccharide conjugate vaccine with BCG provides synergistic protection against murine tuberculosis Open
Tuberculosis (TB) remains a major global health challenge claiming over 1 million lives annually. Bacillus Calmette-Guérin (BCG), the only licensed vaccine against TB, provides limited efficacy against pulmonary TB in adults and only parti…
View article: Topological isomers of a potent wound healing peptide: Structural insights and implications for bioactivity
Topological isomers of a potent wound healing peptide: Structural insights and implications for bioactivity Open
There are numerous examples of topological isomers in organic chemistry, but such isomers are rare in disulfide-rich peptides. Here, we characterize two structurally well-defined topological isomers in a peptide (GRN-P4A) containing the mi…
View article: Structural analysis of an <i>Asterias rubens</i> peptide indicates the presence of a disulfide‐directed β‐hairpin fold
Structural analysis of an <i>Asterias rubens</i> peptide indicates the presence of a disulfide‐directed β‐hairpin fold Open
Sea stars are an abundant group of marine invertebrates that display remarkably robust regenerative capabilities throughout all life stages. Numerous proteins and peptides have been identified in a proteome study on the coelomic fluid (bio…
View article: A second-generation recombinant BCG strain combines protection against murine tuberculosis with an enhanced safety profile in immunocompromised hosts
A second-generation recombinant BCG strain combines protection against murine tuberculosis with an enhanced safety profile in immunocompromised hosts Open
Bacille Calmette-Guérin (BCG) remains the only licensed vaccine against tuberculosis (TB). While BCG protects against TB in children, its protection against pulmonary TB in adults is suboptimal, and the development of a better TB vaccine i…
View article: A modular self-assembling and self-adjuvanting multiepitope peptide nanoparticle vaccine platform to improve the efficacy and immunogenicity of BCG
A modular self-assembling and self-adjuvanting multiepitope peptide nanoparticle vaccine platform to improve the efficacy and immunogenicity of BCG Open
After more than a century since its initial development, Bacille Calmette-Guérin (BCG) remains the only licensed vaccine against tuberculosis (TB). Subunit boosters are considered a viable strategy to enhance BCG efficacy, which often wane…
View article: Next-generation vaccines for tropical infectious diseases
Next-generation vaccines for tropical infectious diseases Open
Tropical infectious diseases inflict an unacceptable burden of disease on humans living in developing countries. Although anti-pathogenic drugs have been widely used, they carry a constant threat of selecting for resistance. Vaccines offer…
View article: Polyphenylalanine as a self-adjuvanting delivery system for peptide-based vaccines: the role of peptide conformation
Polyphenylalanine as a self-adjuvanting delivery system for peptide-based vaccines: the role of peptide conformation Open
Peptide-based vaccines are composed of minimal microbial components that are required to stimulate immune responses. Peptide antigens are easy to produce, relatively cheap and non-toxic. They are also able to activate the immune system in …
View article: Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells
Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells Open
A decline in the prevalence of parasites such as hookworms appears to be correlated with the rise in non-communicable inflammatory conditions in people from high- and middle-income countries. This correlation has led to studies that have i…
View article: Intelligent decision-making method of TBM operating parameters based on multiple constraints and objective optimization
Intelligent decision-making method of TBM operating parameters based on multiple constraints and objective optimization Open
The decision-making of TBM operating parameters has an important guiding significance for TBM safe and efficient construction, and it has been one of the research hotpots in the field of TBM tunneling. For this purpose, this paper introduc…
View article: Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines
Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines Open
A new vaccine immunostimulatory (adjuvant) system was developed based on fully defined polymers built from native amino acids.
View article: The application of self-assembled nanostructures in peptide-based subunit vaccine development
The application of self-assembled nanostructures in peptide-based subunit vaccine development Open
View article: Back Cover: Lipopeptide Nanoparticles: Development of Vaccines against Hookworm Parasite (ChemMedChem 10/2015)
Back Cover: Lipopeptide Nanoparticles: Development of Vaccines against Hookworm Parasite (ChemMedChem 10/2015) Open
The back cover picture shows the action of a vaccine candidate against hookworm. B-cell peptide epitopes derived from hookworm protease Na-APR-1 were incorporated into lipid core peptides (structure shown on the right). Proper epitope conf…