Guanjun Chen
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View article: ZNF334 truncation mutation drives cold-induced autoinflammation
ZNF334 truncation mutation drives cold-induced autoinflammation Open
The role of zinc finger protein 334 (ZNF334) in immunological processes remains unknown. We identified a ZNF334 truncation mutation (p.Thr399fs) in a rare case of late-onset cold-induced autoinflammatory disease with elevated TNF-α, IL-1β,…
View article: Study on the Gene Regulatory Effects in Leukemia Based on Multi-omics Mendelian Randomization, Network Pharmacology, and Functional Validation
Study on the Gene Regulatory Effects in Leukemia Based on Multi-omics Mendelian Randomization, Network Pharmacology, and Functional Validation Open
Background: Leukemia is a type of malignant hematological disease, for which conventional treatments have limited efficacy, and there is an urgent need for novel therapeutic targets.This study investigates the causal effects of gene expres…
View article: Nrf2/STAT3-mediated activation of SLC6A3 underlies the neuroprotective effect of quercetin in ischemic stroke
Nrf2/STAT3-mediated activation of SLC6A3 underlies the neuroprotective effect of quercetin in ischemic stroke Open
Our findings identify the Nrf2/STAT3/SLC6A3 axis as a key mediator of quercetin's neuroprotective effects in ischemic stroke. To our knowledge, this is the first study to identify the Nrf2/STAT3/SLC6A3 axis as a key regulatory pathway unde…
View article: Role of gut microbiota in thalassemia: a review of therapeutic prospects
Role of gut microbiota in thalassemia: a review of therapeutic prospects Open
In recent years, the study of gut microbiota has gradually become a research hotspot in the field of medicine, as gut microbiota dysbiosis is closely related to various diseases. Thalassemia, as a hereditary hemoglobinopathy, has a complex…
View article: Comprehensive Multi-Omics Analysis Identifies FUT1 as a Prognostic and Therapeutic Biomarker Across Pan-Cancer
Comprehensive Multi-Omics Analysis Identifies FUT1 as a Prognostic and Therapeutic Biomarker Across Pan-Cancer Open
Fucosyltransferase 1 encodes a Golgi membrane protein involved in H-antigen precursor production and plays a critical role in tumor-associated glycosylation and angiogenesis. While FUT1 is known to enhance tumor stemness, adhesion, migrati…
View article: Comparison of pegaspargase with concurrent radiation <i>vs</i>. P-GEMOX with sequential radiation in early-stage NK/T-cell lymphoma
Comparison of pegaspargase with concurrent radiation <i>vs</i>. P-GEMOX with sequential radiation in early-stage NK/T-cell lymphoma Open
P+CCRT is associated with comparable clinical outcomes compared to P-GEMOX + SERT in early-stage NKTCL, with comparable adverse events. Additionally, P+CCRT offers the benefit of a more streamlined treatment regimen with a shorter cycle. G…
View article: Bortezomib, lenalidomide, and dexamethasone versus bortezomib, doxorubicin, and dexamethasone in newly diagnosed multiple myeloma
Bortezomib, lenalidomide, and dexamethasone versus bortezomib, doxorubicin, and dexamethasone in newly diagnosed multiple myeloma Open
Bortezomib, lenalidomide, and dexamethasone (VRD), and bortezomib, doxorubicin, and dexamethasone (PAD), are commonly used in induction regimens for patients with newly diagnosed multiple myeloma (NDMM) in China. This real-world study enro…
View article: Prenatal Environmental Antibiotic Exposure and Autism Spectrum Disorder Symptoms in Children at 3 Years of Age: Findings from the Ma’anshan Birth Cohort Study
Prenatal Environmental Antibiotic Exposure and Autism Spectrum Disorder Symptoms in Children at 3 Years of Age: Findings from the Ma’anshan Birth Cohort Study Open
Antibiotic exposure during pregnancy may affect the neurodevelopment of children, but biomonitoring-based population studies on this class of new pollutants are lacking. We conducted a prospective birth cohort study of 2860 mother-child pa…
View article: Development of an m6A subtype classifier to guide precision therapy for patients with bladder cancer
Development of an m6A subtype classifier to guide precision therapy for patients with bladder cancer Open
Purpose: Bladder cancer (BLCA) is a highly heterogeneous tumor. We aim to construct a classifier from the perspective of N6-methyladenosine methylation (m6A) to identify patients with different prognostic risks and treatment responsiveness…
View article: Direct Degradation of Fresh and Dried Macroalgae by Agarivorans albus B2Z047
Direct Degradation of Fresh and Dried Macroalgae by Agarivorans albus B2Z047 Open
Marine macroalgae are increasingly recognized for their significant biological and economic potential. The key to unlocking this potential lies in the efficient degradation of all carbohydrates from the macroalgae biomass. However, a varie…
View article: Combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma: Differentiation using radiomics based on Multitemporal CT images
Combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma: Differentiation using radiomics based on Multitemporal CT images Open
Purpose: To investigate the value of radiomics in differentiating combined hepatocellular-cholangiocarcinoma (cHCC-CCA) and hepatocellular carcinoma (HCC). Materials and Methods: We retrospectively collected the clinical, serum biomarkers …
View article: Cultivating the uncultured: Harnessing the “sandwich agar plate” approach to isolate heme‐dependent bacteria from marine sediment
Cultivating the uncultured: Harnessing the “sandwich agar plate” approach to isolate heme‐dependent bacteria from marine sediment Open
In the classical microbial isolation technique, the isolation process inevitably destroys all microbial interactions and thus makes it difficult to culture the many microorganisms that rely on these interactions for survival. In this study…
View article: Development of an m6A subtype classifier to guide precision therapy for patients with bladder cancer
Development of an m6A subtype classifier to guide precision therapy for patients with bladder cancer Open
Purpose: Bladder cancer (BLCA) is a highly heterogeneous tumor. We aim to construct a classifier from the perspective of N6-methyladenosine methylation (m6A) to identify patients with different prognostic risks and treatment responsiveness…
View article: The causal relationship between gut microbiota and leukemia: a two-sample Mendelian randomization study
The causal relationship between gut microbiota and leukemia: a two-sample Mendelian randomization study Open
Background The association between gut microbiota and leukemia has been established, but the causal relationship between the two remains unclear. Methods A bidirectional two-sample Mendelian randomization (MR) was used to analyze the causa…
View article: WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis
WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis Open
Background Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC. WGX50, an organic extract derived from…
View article: Phylogenetics and biomineralization of a novel magnetotactic <i>Gammaproteobacterium</i> from a freshwater lake in Beijing, China
Phylogenetics and biomineralization of a novel magnetotactic <i>Gammaproteobacterium</i> from a freshwater lake in Beijing, China Open
Magnetotactic bacteria (MTB) have the remarkable capability of producing intracellularly membrane-enveloped magnetic nanocrystals (i.e. magnetosomes) and swimming along geomagnetic field lines. Despite more than 50 years of research, bacte…
View article: Corrigendum: Impact of intestinal microbiota on metabolic toxicity and potential detoxification of amygdalin
Corrigendum: Impact of intestinal microbiota on metabolic toxicity and potential detoxification of amygdalin Open
[This corrects the article DOI: 10.3389/fmicb.2022.1030516.].
View article: An UHPLC-QE-Orbitrap-MS method for accurate quantification of short-chain fatty acids in serum from an older Chinese population
An UHPLC-QE-Orbitrap-MS method for accurate quantification of short-chain fatty acids in serum from an older Chinese population Open
Short-chain fatty acids (SCFAs), such as acetic acid, propionic acid, lactic acid, β-hydroxybutyric acid, and crotonic acid, play key biological roles and are also strongly associated with the maintenance of health and the development of a…
View article: Multi-Omics Clustering Reveals Disulfidptosis Typing in Hepatocellular Carcinoma and Correlates with Immune Features
Multi-Omics Clustering Reveals Disulfidptosis Typing in Hepatocellular Carcinoma and Correlates with Immune Features Open
Hepatocellular carcinoma (HCC) is a highly prevalent and deadly cancer, with limited treatment options for advanced-stage patients. This study aimed to explore the potential of disulfidptosis, a novel form of cell death, as a prognostic an…
View article: Association of Long Noncoding RNA Expression Signatures with Stress-Induced Myocardial Perfusion Defects
Association of Long Noncoding RNA Expression Signatures with Stress-Induced Myocardial Perfusion Defects Open
Stress-induced myocardial perfusion defects found in dipyridamole–thallium-201 single-photon emission computed tomography imaging may indicate vascular perfusion abnormalities and risk of obstructive or nonobstructive coronary heart diseas…
View article: Comparative genomics reveal distinct potential of Tamlana sp. S12 for algal polysaccharide degradation
Comparative genomics reveal distinct potential of Tamlana sp. S12 for algal polysaccharide degradation Open
Introduction Macroalgae contain various polysaccharides that serve as nutrient sources Introduction: Macroalgae contain various polysaccharides that serve as nutrient sources for marine bacteria. Carbohydrate-active enzymes (CAZymes) are t…
View article: Construction of a novel molecular typing and scoring system for anoikis distinguishes between different prognostic risks and treatment responsiveness in low-grade glioma
Construction of a novel molecular typing and scoring system for anoikis distinguishes between different prognostic risks and treatment responsiveness in low-grade glioma Open
Background The main factors responsible for low-grade glioma (LGG)s’ poor prognosis and treatment effectiveness include recurrence and malignant progression. A specific type of programmed cell death, known as anoikis, which is crucial for …
View article: Niche Modification by Sulfate-Reducing Bacteria Drives Microbial Community Assembly in Anoxic Marine Sediments
Niche Modification by Sulfate-Reducing Bacteria Drives Microbial Community Assembly in Anoxic Marine Sediments Open
Our model offers insight into the ecological properties of SRB and identifies a previously undocumented dimension of OM degradation. This targeted inhibition approach could provide a novel framework for illustrating how functional microbia…
View article: Construction of the Novel Immune Risk Scoring System Related to CD8 + T Cells in Uterine Corpus Endometrial Carcinoma
Construction of the Novel Immune Risk Scoring System Related to CD8 + T Cells in Uterine Corpus Endometrial Carcinoma Open
Uterine corpus endometrial carcinoma (UCEC) is a gynecological malignant tumor with high incidence and poor prognosis. Although immunotherapy has brought huge survival benefits for some specific patients, the traditional evaluation indicat…
View article: UXT-V1 contributes to the malignant phenotypes of colorectal cancer via GSK3β by activating Wnt/β-catenin pathway
UXT-V1 contributes to the malignant phenotypes of colorectal cancer via GSK3β by activating Wnt/β-catenin pathway Open
Background: Colorectal cancer (CRC) is one of malignant tumors that seriously threatening human health. β-catenin is a central hub in Wnt pathway, aberrant activation of Wnt/β-catenin signaling pathway promotes the tumorigenesis/progressio…