Guanmin Jiang
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View article: AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progression
AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progression Open
The androgen receptor (AR) usually drives prostate cancer cell growth, yet its role in immune cells such as tumour-associated macrophages (TAMs), remains unclear. We find that macrophages co-expressing AR and triggering receptor expressed …
View article: Targeting Melatonin to Mitochondria Mitigates Castration‐Resistant Prostate Cancer by Inducing Pyroptosis
Targeting Melatonin to Mitochondria Mitigates Castration‐Resistant Prostate Cancer by Inducing Pyroptosis Open
Prostate cancer frequently progresses to castration‐resistant prostate cancer (CRPC) following androgen deprivation therapy, presenting a significant clinical challenge. Targeting tumor metabolism, particularly mitochondrial pathways, offe…
View article: H3K36me2 methyltransferase NSD2/WHSC1 promotes triple-negative breast cancer metastasis via activation of ULK1-dependent autophagy
H3K36me2 methyltransferase NSD2/WHSC1 promotes triple-negative breast cancer metastasis via activation of ULK1-dependent autophagy Open
Metastasis is the primary cause for treatment failure and poor prognosis in patients with triple-negative breast cancer (TNBC). Macroautophagy/autophagy plays a crucial role in tumor growth and metastasis. Genetic or epigenetic regulation …
View article: MRanalysis: a comprehensive online platform for integrated, multimethod Mendelian randomization and associated post-GWAS analyses
MRanalysis: a comprehensive online platform for integrated, multimethod Mendelian randomization and associated post-GWAS analyses Open
Background Mendelian randomization (MR) is a powerful epidemiological method for inferring causal relationships between exposures and outcomes using genome-wide association study (GWAS) data. However, its adoption is limited by inconsisten…
View article: Supplementary Table S1-2 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB
Supplementary Table S1-2 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB Open
The sequences of the siRNAs are listed in Supplementary Table S1. And the sequences of the primers, ChIP primers and MeRIP primers used are listed in Supplementary Table S2.
View article: Supplementary Figures 1-4 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB
Supplementary Figures 1-4 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB Open
This PDF contais Supplementary Figures 1-4.
View article: Supplementary Table S3 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB
Supplementary Table S3 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB Open
The differentially expressed genes in the DU145-shNFIB cells vs DU145-shNC cells was listed in Supplementary Table S3.
View article: Data from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB
Data from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB Open
The widespread use of androgen receptor (AR) signaling inhibitors has led to an increased incidence of AR-negative castration-resistant prostate cancer (CRPC), limiting effective treatment and patient survival. A more comprehensive underst…
View article: Data from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB
Data from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB Open
The widespread use of androgen receptor (AR) signaling inhibitors has led to an increased incidence of AR-negative castration-resistant prostate cancer (CRPC), limiting effective treatment and patient survival. A more comprehensive underst…
View article: Supplementary Table S4 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB
Supplementary Table S4 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB Open
Proteins that bind with NFIB rather than IgG, in both NFIB_1 and NFIB_2 samples.
View article: Supplementary Table S1-2 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB
Supplementary Table S1-2 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB Open
The sequences of the siRNAs are listed in Supplementary Table S1. And the sequences of the primers, ChIP primers and MeRIP primers used are listed in Supplementary Table S2.
View article: Supplementary Table S3 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB
Supplementary Table S3 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB Open
The differentially expressed genes in the DU145-shNFIB cells vs DU145-shNC cells was listed in Supplementary Table S3.
View article: Supplementary Figures 1-4 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB
Supplementary Figures 1-4 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB Open
This PDF contais Supplementary Figures 1-4.
View article: Supplementary Table S4 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB
Supplementary Table S4 from m<sup>6</sup>A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB Open
Proteins that bind with NFIB rather than IgG, in both NFIB_1 and NFIB_2 samples.
View article: Identification of Molecular Subtype and Prognostic Signature for Prostate Adenocarcinoma based on Neutrophil Extracellular Traps
Identification of Molecular Subtype and Prognostic Signature for Prostate Adenocarcinoma based on Neutrophil Extracellular Traps Open
Background: Prostate adenocarcinoma (PRAD) is one of the most common cancers in male. Increasing evidences pointed out that Neutrophil Extracellular Traps (NETs) play an important role in tumor angiogenesis, tumor metastasis and drug resis…
View article: Clinical utility of Metagenomic Next-Generation Sequencing on bronchoalveolar lavage fluid in diagnosis of Lower Respiratory Tract Infections
Clinical utility of Metagenomic Next-Generation Sequencing on bronchoalveolar lavage fluid in diagnosis of Lower Respiratory Tract Infections Open
Introduction: In this study, we aimed to evaluate the clinical utility of Metagenomic Next-Generation sequencing (mNGS) on bronchoalveolar lavage fluid (BALF) in diagnosis of Lower Respiratory Tract Infection (LRTIs). Methods : This retros…
View article: COVID‐19 Metabolomic‐Guided Amino Acid Therapy Protects from Inflammation and Disease Sequelae (Adv. Biology 8/2023)
COVID‐19 Metabolomic‐Guided Amino Acid Therapy Protects from Inflammation and Disease Sequelae (Adv. Biology 8/2023) Open
COVID-19 In article 2200265, Guoliang Zhang, Guanmin Jiang, Xi Huang, and co-workers show that the supplementation of citrulline and glutamine (in the center of the picture) may prevent the inflammatory cytokine storm (small solid dots in …
View article: Supplementary Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer
Supplementary Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer Open
Supplementary Data from ALKBH5-Mediated m6A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer
View article: Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer
Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer Open
Resistance to HER2-targeted therapy represents a significant challenge for the successful treatment of patients with breast cancer with HER2-positive tumors. Through a global mass spectrometry–based proteomics approach, we discovered that …
View article: Data from <i>N<sup>6</sup></i>-Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis
Data from <i>N<sup>6</sup></i>-Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis Open
The roles of RNA modification during organ metastasis of cancer cells are not known. Here we established breast cancer lung metastasis cells by three rounds of selection of lung metastatic subpopulations in vivo and designated them as BCLM…
View article: Supplementary Data from <i>N<sup>6</sup></i>-Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis
Supplementary Data from <i>N<sup>6</sup></i>-Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis Open
Table S2
View article: Supplementary Data from <i>N<sup>6</sup></i>-Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis
Supplementary Data from <i>N<sup>6</sup></i>-Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis Open
Supplementary Data
View article: Supplementary Data from <i>N<sup>6</sup></i>-Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis
Supplementary Data from <i>N<sup>6</sup></i>-Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis Open
Table S2
View article: Supplementary Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer
Supplementary Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer Open
Supplementary Data from ALKBH5-Mediated m6A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer